Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment
<p>Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>), 25-hydroxyvitamin D2 (25(OH)D<sub>2</sub>), 25-hydroxyvitamin D3 (25(OH)D<sub>3</sub>), 24,25-dihydroxyvitamin D (24,25(OH...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2019
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| الملخص: | <p>Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>), 25-hydroxyvitamin D2 (25(OH)D<sub>2</sub>), 25-hydroxyvitamin D3 (25(OH)D<sub>3</sub>), 24,25-dihydroxyvitamin D (24,25(OH)<sub>2</sub>D<sub>3</sub>), and 25-hydroxy-3epi-Vitamin D3 (3epi25(OH)D<sub>3</sub>) concentrations in age and weight matched women with and without PCOS was studied.</p> <p><br></p> <p>Methods: Fifty nine non-obese women, 29 with PCOS, and 30 non-PCOS undergoing IVF, matched for age and weight were included. Serum vitamin D metabolites were taken the menstrual cycle prior to commencing controlled ovarian hyperstimulation.</p> <p><br></p> <div>Results: Vitamin D metabolites did not differ between PCOS and controls; however, 25(OH)D<sub>3</sub> correlated with embryo fertilization rates in PCOS patients alone (p = 0.03). For all subjects, 3epi25(OH)D<sub>3</sub> correlated with fertilization rate (p < 0.04) and negatively with HOMA-IR (p < 0.02); 25(OH)D<sub>2</sub> correlated with cleavage rate, G3D3 and blastocyst (p < 0.05; p < 0.009; p < 0.002, respectively). 24,25(OH)<sub>2</sub>D<sub>3</sub> correlated with AMH, antral follicle count, eggs retrieved and top quality embryos (G3D3) (p < 0.03; p < 0.003; p < 0.009; p < 0.002, respectively), and negatively with HOMA-IR (p < 0.01). 1,25(OH)<sub>2</sub>D<sub>3</sub> did not correlate with any of the metabolic or embryo parameters. In slim PCOS, 25(OH)D<sub>3</sub> correlated with increased fertilization rates in PCOS, but other vitamin D parameters did not differ to matched controls.</div> <p><br></p> <div>Conclusion: 3epi25(OH)D<sub>3</sub>, 25(OH)D<sub>2</sub>, and 24,25(OH)<sub>2</sub>D<sub>3</sub>, but not 1,25(OH)<sub>2</sub>D<sub>3</sub>, were associated with embryo parameters suggesting that vitamin D metabolites other than 1,25(OH)<sub>2</sub>D<sub>3</sub> are important in fertility.</div> <h2>Other Information</h2> <p>Published in: Frontiers in Endocrinology<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2019.00013" target="_blank">https://dx.doi.org/10.3389/fendo.2019.00013</a></p> |
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