Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment
<p>Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>), 25-hydroxyvitamin D2 (25(OH)D<sub>2</sub>), 25-hydroxyvitamin D3 (25(OH)D<sub>3</sub>), 24,25-dihydroxyvitamin D (24,25(OH...
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2019
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| _version_ | 1864513525917941760 |
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| author | Thomas Keith Cunningham (9442886) |
| author2 | Victoria Allgar (332894) Soha R. Dargham (3613250) Eric Kilpatrick (18090853) Thozhukat Sathyapalan (704787) Stephen Maguiness (18090856) Haira R. Mokhtar Rudin (18090859) Nour M. Abdul Ghani (18090862) Aishah Latiff (5449250) Stephen L. Atkin (6684368) |
| author2_role | author author author author author author author author author |
| author_facet | Thomas Keith Cunningham (9442886) Victoria Allgar (332894) Soha R. Dargham (3613250) Eric Kilpatrick (18090853) Thozhukat Sathyapalan (704787) Stephen Maguiness (18090856) Haira R. Mokhtar Rudin (18090859) Nour M. Abdul Ghani (18090862) Aishah Latiff (5449250) Stephen L. Atkin (6684368) |
| author_role | author |
| dc.creator.none.fl_str_mv | Thomas Keith Cunningham (9442886) Victoria Allgar (332894) Soha R. Dargham (3613250) Eric Kilpatrick (18090853) Thozhukat Sathyapalan (704787) Stephen Maguiness (18090856) Haira R. Mokhtar Rudin (18090859) Nour M. Abdul Ghani (18090862) Aishah Latiff (5449250) Stephen L. Atkin (6684368) |
| dc.date.none.fl_str_mv | 2019-01-29T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fendo.2019.00013 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Association_of_Vitamin_D_Metabolites_With_Embryo_Development_and_Fertilization_in_Women_With_and_Without_PCOS_Undergoing_Subfertility_Treatment/25331221 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Reproductive medicine vitamin D vitamin D epimers vitamin D metabolites fertilization rates PCOS |
| dc.title.none.fl_str_mv | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>), 25-hydroxyvitamin D2 (25(OH)D<sub>2</sub>), 25-hydroxyvitamin D3 (25(OH)D<sub>3</sub>), 24,25-dihydroxyvitamin D (24,25(OH)<sub>2</sub>D<sub>3</sub>), and 25-hydroxy-3epi-Vitamin D3 (3epi25(OH)D<sub>3</sub>) concentrations in age and weight matched women with and without PCOS was studied.</p> <p><br></p> <p>Methods: Fifty nine non-obese women, 29 with PCOS, and 30 non-PCOS undergoing IVF, matched for age and weight were included. Serum vitamin D metabolites were taken the menstrual cycle prior to commencing controlled ovarian hyperstimulation.</p> <p><br></p> <div>Results: Vitamin D metabolites did not differ between PCOS and controls; however, 25(OH)D<sub>3</sub> correlated with embryo fertilization rates in PCOS patients alone (p = 0.03). For all subjects, 3epi25(OH)D<sub>3</sub> correlated with fertilization rate (p < 0.04) and negatively with HOMA-IR (p < 0.02); 25(OH)D<sub>2</sub> correlated with cleavage rate, G3D3 and blastocyst (p < 0.05; p < 0.009; p < 0.002, respectively). 24,25(OH)<sub>2</sub>D<sub>3</sub> correlated with AMH, antral follicle count, eggs retrieved and top quality embryos (G3D3) (p < 0.03; p < 0.003; p < 0.009; p < 0.002, respectively), and negatively with HOMA-IR (p < 0.01). 1,25(OH)<sub>2</sub>D<sub>3</sub> did not correlate with any of the metabolic or embryo parameters. In slim PCOS, 25(OH)D<sub>3</sub> correlated with increased fertilization rates in PCOS, but other vitamin D parameters did not differ to matched controls.</div> <p><br></p> <div>Conclusion: 3epi25(OH)D<sub>3</sub>, 25(OH)D<sub>2</sub>, and 24,25(OH)<sub>2</sub>D<sub>3</sub>, but not 1,25(OH)<sub>2</sub>D<sub>3</sub>, were associated with embryo parameters suggesting that vitamin D metabolites other than 1,25(OH)<sub>2</sub>D<sub>3</sub> are important in fertility.</div> <h2>Other Information</h2> <p>Published in: Frontiers in Endocrinology<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2019.00013" target="_blank">https://dx.doi.org/10.3389/fendo.2019.00013</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6ec3e170a7e8be362ce329142c0e7fad |
| identifier_str_mv | 10.3389/fendo.2019.00013 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25331221 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility TreatmentThomas Keith Cunningham (9442886)Victoria Allgar (332894)Soha R. Dargham (3613250)Eric Kilpatrick (18090853)Thozhukat Sathyapalan (704787)Stephen Maguiness (18090856)Haira R. Mokhtar Rudin (18090859)Nour M. Abdul Ghani (18090862)Aishah Latiff (5449250)Stephen L. Atkin (6684368)Biomedical and clinical sciencesClinical sciencesReproductive medicinevitamin Dvitamin D epimersvitamin D metabolitesfertilization ratesPCOS<p>Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D<sub>3</sub>), 25-hydroxyvitamin D2 (25(OH)D<sub>2</sub>), 25-hydroxyvitamin D3 (25(OH)D<sub>3</sub>), 24,25-dihydroxyvitamin D (24,25(OH)<sub>2</sub>D<sub>3</sub>), and 25-hydroxy-3epi-Vitamin D3 (3epi25(OH)D<sub>3</sub>) concentrations in age and weight matched women with and without PCOS was studied.</p> <p><br></p> <p>Methods: Fifty nine non-obese women, 29 with PCOS, and 30 non-PCOS undergoing IVF, matched for age and weight were included. Serum vitamin D metabolites were taken the menstrual cycle prior to commencing controlled ovarian hyperstimulation.</p> <p><br></p> <div>Results: Vitamin D metabolites did not differ between PCOS and controls; however, 25(OH)D<sub>3</sub> correlated with embryo fertilization rates in PCOS patients alone (p = 0.03). For all subjects, 3epi25(OH)D<sub>3</sub> correlated with fertilization rate (p < 0.04) and negatively with HOMA-IR (p < 0.02); 25(OH)D<sub>2</sub> correlated with cleavage rate, G3D3 and blastocyst (p < 0.05; p < 0.009; p < 0.002, respectively). 24,25(OH)<sub>2</sub>D<sub>3</sub> correlated with AMH, antral follicle count, eggs retrieved and top quality embryos (G3D3) (p < 0.03; p < 0.003; p < 0.009; p < 0.002, respectively), and negatively with HOMA-IR (p < 0.01). 1,25(OH)<sub>2</sub>D<sub>3</sub> did not correlate with any of the metabolic or embryo parameters. In slim PCOS, 25(OH)D<sub>3</sub> correlated with increased fertilization rates in PCOS, but other vitamin D parameters did not differ to matched controls.</div> <p><br></p> <div>Conclusion: 3epi25(OH)D<sub>3</sub>, 25(OH)D<sub>2</sub>, and 24,25(OH)<sub>2</sub>D<sub>3</sub>, but not 1,25(OH)<sub>2</sub>D<sub>3</sub>, were associated with embryo parameters suggesting that vitamin D metabolites other than 1,25(OH)<sub>2</sub>D<sub>3</sub> are important in fertility.</div> <h2>Other Information</h2> <p>Published in: Frontiers in Endocrinology<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2019.00013" target="_blank">https://dx.doi.org/10.3389/fendo.2019.00013</a></p>2019-01-29T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fendo.2019.00013https://figshare.com/articles/journal_contribution/Association_of_Vitamin_D_Metabolites_With_Embryo_Development_and_Fertilization_in_Women_With_and_Without_PCOS_Undergoing_Subfertility_Treatment/25331221CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253312212019-01-29T03:00:00Z |
| spellingShingle | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment Thomas Keith Cunningham (9442886) Biomedical and clinical sciences Clinical sciences Reproductive medicine vitamin D vitamin D epimers vitamin D metabolites fertilization rates PCOS |
| status_str | publishedVersion |
| title | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment |
| title_full | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment |
| title_fullStr | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment |
| title_full_unstemmed | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment |
| title_short | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment |
| title_sort | Association of Vitamin D Metabolites With Embryo Development and Fertilization in Women With and Without PCOS Undergoing Subfertility Treatment |
| topic | Biomedical and clinical sciences Clinical sciences Reproductive medicine vitamin D vitamin D epimers vitamin D metabolites fertilization rates PCOS |