Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study
<h3>Background</h3><p dir="ltr">We sought to evaluate the clinical characteristics and risk factors for early versus late pulmonary embolism (PE) in trauma patients. </p><h3>Methods</h3><p dir="ltr">This was a retrospective analysis of in...
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2022
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| _version_ | 1864513547717836800 |
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| author | Tariq Siddiqui (444882) |
| author2 | Mohammad Asim (178880) Khalid Ahmed (710040) Saji Mathradikkal (21397949) Zeenat Bakhsh (17883045) Maarij Masood (15954225) Ammar Al-Hassani (14150046) Syed Nabir (14631245) Nadeem Ahmed (10571900) Gustav Strandvik (9756205) Ayman El-Menyar (440103) Hassan Al-Thani (440106) |
| author2_role | author author author author author author author author author author author |
| author_facet | Tariq Siddiqui (444882) Mohammad Asim (178880) Khalid Ahmed (710040) Saji Mathradikkal (21397949) Zeenat Bakhsh (17883045) Maarij Masood (15954225) Ammar Al-Hassani (14150046) Syed Nabir (14631245) Nadeem Ahmed (10571900) Gustav Strandvik (9756205) Ayman El-Menyar (440103) Hassan Al-Thani (440106) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tariq Siddiqui (444882) Mohammad Asim (178880) Khalid Ahmed (710040) Saji Mathradikkal (21397949) Zeenat Bakhsh (17883045) Maarij Masood (15954225) Ammar Al-Hassani (14150046) Syed Nabir (14631245) Nadeem Ahmed (10571900) Gustav Strandvik (9756205) Ayman El-Menyar (440103) Hassan Al-Thani (440106) |
| dc.date.none.fl_str_mv | 2022-10-21T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/ijgm.s387880 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Clinical_Characteristics_and_Risk_Factors_for_Early_versus_Late_Pulmonary_Embolism_in_Trauma_Patients_A_Retrospective_Observational_Study/29116937 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology pulmonary embolism trauma timing risk factors outcomes |
| dc.title.none.fl_str_mv | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">We sought to evaluate the clinical characteristics and risk factors for early versus late pulmonary embolism (PE) in trauma patients. </p><h3>Methods</h3><p dir="ltr">This was a retrospective analysis of injured patients who presented with a confirmed PE between 2013 and 2019. Data were analysed and compared for patients with early PE (≤ 4 days) versus late PE (> 4 days post-trauma). </p><h3>Results</h3><p dir="ltr">The study included 82 consecutive trauma patients with confirmed diagnosis of PE. The mean age of patients was 42.3 ± 16.2 years. The majority were males (79.3%) and the median time from injury to PE was 10 days. Of the PE cases, 24 (29.3%) had early PE, while 58 (70.7%) had late PE. The early PE group had higher rates of surgical intervention within 24 hours of admission than the late PE group (p = 0.001). Also, the rate of sub-segmental thrombi was significantly higher in the early PE group (p = 0.01). The late PE group sustained more moderate-to-severe injuries ie, GCS ED < 13 (p = 0.03) and the median time from injury to PE diagnosis was 15 days (p = 0.001). After adjusting for the potential covariates, surgery within 24 hours of admission [adjusted odds ratio 37.58 (95% confidence interval 3.393– 416.20), p = 0.003] was found to be significant independent predictor of early PE in trauma patients. </p><h3>Conclusion</h3><p dir="ltr">One-third of post-trauma PEs occurs early after trauma and the surgical intervention within the first 24 hours of admission is a major risk factor. A prospective study is needed to develop an objective risk assessment for the prevention and detection of early and late PE post-trauma.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of General Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/ijgm.s387880" target="_blank">https://dx.doi.org/10.2147/ijgm.s387880</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_70a2bad626f0e0a330396e54190edb15 |
| identifier_str_mv | 10.2147/ijgm.s387880 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29116937 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational StudyTariq Siddiqui (444882)Mohammad Asim (178880)Khalid Ahmed (710040)Saji Mathradikkal (21397949)Zeenat Bakhsh (17883045)Maarij Masood (15954225)Ammar Al-Hassani (14150046)Syed Nabir (14631245)Nadeem Ahmed (10571900)Gustav Strandvik (9756205)Ayman El-Menyar (440103)Hassan Al-Thani (440106)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologypulmonary embolismtraumatimingrisk factorsoutcomes<h3>Background</h3><p dir="ltr">We sought to evaluate the clinical characteristics and risk factors for early versus late pulmonary embolism (PE) in trauma patients. </p><h3>Methods</h3><p dir="ltr">This was a retrospective analysis of injured patients who presented with a confirmed PE between 2013 and 2019. Data were analysed and compared for patients with early PE (≤ 4 days) versus late PE (> 4 days post-trauma). </p><h3>Results</h3><p dir="ltr">The study included 82 consecutive trauma patients with confirmed diagnosis of PE. The mean age of patients was 42.3 ± 16.2 years. The majority were males (79.3%) and the median time from injury to PE was 10 days. Of the PE cases, 24 (29.3%) had early PE, while 58 (70.7%) had late PE. The early PE group had higher rates of surgical intervention within 24 hours of admission than the late PE group (p = 0.001). Also, the rate of sub-segmental thrombi was significantly higher in the early PE group (p = 0.01). The late PE group sustained more moderate-to-severe injuries ie, GCS ED < 13 (p = 0.03) and the median time from injury to PE diagnosis was 15 days (p = 0.001). After adjusting for the potential covariates, surgery within 24 hours of admission [adjusted odds ratio 37.58 (95% confidence interval 3.393– 416.20), p = 0.003] was found to be significant independent predictor of early PE in trauma patients. </p><h3>Conclusion</h3><p dir="ltr">One-third of post-trauma PEs occurs early after trauma and the surgical intervention within the first 24 hours of admission is a major risk factor. A prospective study is needed to develop an objective risk assessment for the prevention and detection of early and late PE post-trauma.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of General Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/ijgm.s387880" target="_blank">https://dx.doi.org/10.2147/ijgm.s387880</a></p>2022-10-21T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/ijgm.s387880https://figshare.com/articles/journal_contribution/Clinical_Characteristics_and_Risk_Factors_for_Early_versus_Late_Pulmonary_Embolism_in_Trauma_Patients_A_Retrospective_Observational_Study/29116937CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/291169372022-10-21T06:00:00Z |
| spellingShingle | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study Tariq Siddiqui (444882) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology pulmonary embolism trauma timing risk factors outcomes |
| status_str | publishedVersion |
| title | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study |
| title_full | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study |
| title_fullStr | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study |
| title_full_unstemmed | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study |
| title_short | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study |
| title_sort | Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology pulmonary embolism trauma timing risk factors outcomes |