Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

<h3>Background</h3><p dir="ltr">Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metalloproteinase-8 (MMP-8) is expressed...

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Bibliographic Details
Main Author: Muge Sarper (3855454) (author)
Other Authors: Michael D. Allen (263658) (author), Jenny Gomm (3855451) (author), Linda Haywood (3855460) (author), Julie Decock (44558) (author), Sally Thirkettle (702179) (author), Ahsen Ustaoglu (3855448) (author), Shah-Jalal Sarker (3502589) (author), John Marshall (39501) (author), Dylan R. Edwards (7957886) (author), J. Louise Jones (7687964) (author)
Published: 2017
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
Ductal carcinoma in situ
Myoepithelial cell
Microenvironment
MMP-8
Adhesion
Hemidesmosomes
Organotypic assays
Invasion
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