Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review
<h3>Background</h3><p dir="ltr">Ramucirumab is an anti-angiogenic drug that received Food and Drug Administration (FDA)-approvals for treatments of many cancers. Gastrointestinal fistulas and perforations are recognized side effects of anti-angiogenic therapies, however,...
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2023
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| _version_ | 1864513542588203008 |
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| author | Ahmed Abdalhadi (14152962) |
| author2 | Mouhammad J Alawad (17317030) Nabil E. Omar (9545756) Muhammed Hajmusa (17317033) Mohammed Gaber (14151942) Alaaeldin Shablak (14778097) |
| author2_role | author author author author author |
| author_facet | Ahmed Abdalhadi (14152962) Mouhammad J Alawad (17317030) Nabil E. Omar (9545756) Muhammed Hajmusa (17317033) Mohammed Gaber (14151942) Alaaeldin Shablak (14778097) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmed Abdalhadi (14152962) Mouhammad J Alawad (17317030) Nabil E. Omar (9545756) Muhammed Hajmusa (17317033) Mohammed Gaber (14151942) Alaaeldin Shablak (14778097) |
| dc.date.none.fl_str_mv | 2023-03-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cpccr.2022.100214 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Tracheoesophageal_fistula_and_esophageal_perforation_in_a_patient_with_advanced_gastroesophageal_junction_tumor_post_ramucirumab_treatment_A_case_report_and_literature_review/24474667 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Tracheoesophageal fistula Gastroesophageal junction tumor Ramucirumab Anti-angiogenic FOLFOX GEJ PD-L1 HER2 EGD MMR VEGF NSCLC |
| dc.title.none.fl_str_mv | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Ramucirumab is an anti-angiogenic drug that received Food and Drug Administration (FDA)-approvals for treatments of many cancers. Gastrointestinal fistulas and perforations are recognized side effects of anti-angiogenic therapies, however, there are very few reported cases of these conditions in patients managed with Ramucirumab. Here we report a case of a 46-year-old gentleman with a stage four gastroesophageal junction tumor, who developed multiple tracheoesophageal fistulas post ramucirumab containing regimen. To the best of our knowledge, this is the first case report that describes a serious uncommon complication of ramucirumab in a patient with a gastroesophageal junction tumor.</p><h2>Other Information</h2><p dir="ltr">Published in: Current Problems in Cancer: Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpccr.2022.100214" target="_blank">https://dx.doi.org/10.1016/j.cpccr.2022.100214</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_70dc410cd483ea2bc71eae62996944b8 |
| identifier_str_mv | 10.1016/j.cpccr.2022.100214 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24474667 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature reviewAhmed Abdalhadi (14152962)Mouhammad J Alawad (17317030)Nabil E. Omar (9545756)Muhammed Hajmusa (17317033)Mohammed Gaber (14151942)Alaaeldin Shablak (14778097)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesTracheoesophageal fistulaGastroesophageal junction tumorRamucirumabAnti-angiogenicFOLFOXGEJPD-L1HER2EGDMMRVEGFNSCLC<h3>Background</h3><p dir="ltr">Ramucirumab is an anti-angiogenic drug that received Food and Drug Administration (FDA)-approvals for treatments of many cancers. Gastrointestinal fistulas and perforations are recognized side effects of anti-angiogenic therapies, however, there are very few reported cases of these conditions in patients managed with Ramucirumab. Here we report a case of a 46-year-old gentleman with a stage four gastroesophageal junction tumor, who developed multiple tracheoesophageal fistulas post ramucirumab containing regimen. To the best of our knowledge, this is the first case report that describes a serious uncommon complication of ramucirumab in a patient with a gastroesophageal junction tumor.</p><h2>Other Information</h2><p dir="ltr">Published in: Current Problems in Cancer: Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpccr.2022.100214" target="_blank">https://dx.doi.org/10.1016/j.cpccr.2022.100214</a></p>2023-03-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cpccr.2022.100214https://figshare.com/articles/journal_contribution/Tracheoesophageal_fistula_and_esophageal_perforation_in_a_patient_with_advanced_gastroesophageal_junction_tumor_post_ramucirumab_treatment_A_case_report_and_literature_review/24474667CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244746672023-03-01T00:00:00Z |
| spellingShingle | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review Ahmed Abdalhadi (14152962) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Tracheoesophageal fistula Gastroesophageal junction tumor Ramucirumab Anti-angiogenic FOLFOX GEJ PD-L1 HER2 EGD MMR VEGF NSCLC |
| status_str | publishedVersion |
| title | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review |
| title_full | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review |
| title_fullStr | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review |
| title_full_unstemmed | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review |
| title_short | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review |
| title_sort | Tracheoesophageal fistula and esophageal perforation in a patient with advanced gastroesophageal junction tumor post ramucirumab treatment. A case report and literature review |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Tracheoesophageal fistula Gastroesophageal junction tumor Ramucirumab Anti-angiogenic FOLFOX GEJ PD-L1 HER2 EGD MMR VEGF NSCLC |