Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies
<p dir="ltr">The present study aimed to optimize Needle-Free Liquid Jet Injection (NFLJI) for Mental Incisive Nerve Blocks (MINB) and evaluate its clinical safety and feasibility. A MINB protocol was developed and optimized by series of NFLJI experiments in soft tissue phantoms and c...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , , , |
| منشور في: |
2021
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513551474884608 |
|---|---|
| author | Qiman Gao (12107281) |
| author2 | Anna Henley (12107284) Geoffroy Noël (355057) Zovinar Der Khatchadourian (12107287) Doaa Taqi (9689295) Mohammad Abusamak (10712848) Zixin He (12107278) Swen Grœn (17191330) Rani Taher (17191333) Karim Menassa (17191336) Ana Velly (7307576) Elham Emami (4007807) Luc Mongeau (11189809) Faleh Tamimi (2867255) |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Qiman Gao (12107281) Anna Henley (12107284) Geoffroy Noël (355057) Zovinar Der Khatchadourian (12107287) Doaa Taqi (9689295) Mohammad Abusamak (10712848) Zixin He (12107278) Swen Grœn (17191330) Rani Taher (17191333) Karim Menassa (17191336) Ana Velly (7307576) Elham Emami (4007807) Luc Mongeau (11189809) Faleh Tamimi (2867255) |
| author_role | author |
| dc.creator.none.fl_str_mv | Qiman Gao (12107281) Anna Henley (12107284) Geoffroy Noël (355057) Zovinar Der Khatchadourian (12107287) Doaa Taqi (9689295) Mohammad Abusamak (10712848) Zixin He (12107278) Swen Grœn (17191330) Rani Taher (17191333) Karim Menassa (17191336) Ana Velly (7307576) Elham Emami (4007807) Luc Mongeau (11189809) Faleh Tamimi (2867255) |
| dc.date.none.fl_str_mv | 2021-11-20T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ijpharm.2021.121197 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Needle-free_Mental_Incisive_Nerve_Block_In_vitro_Cadaveric_and_Pilot_Clinical_Studies/24339472 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Dental anesthesia Mental nerve Jet injections Pilot studies Feasibility studies Randomized controlled trial Paresthesia |
| dc.title.none.fl_str_mv | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The present study aimed to optimize Needle-Free Liquid Jet Injection (NFLJI) for Mental Incisive Nerve Blocks (MINB) and evaluate its clinical safety and feasibility. A MINB protocol was developed and optimized by series of NFLJI experiments in soft tissue phantoms and cadavers, then validated in two pilot Randomized Controlled Trials (RCT). The NFLJI penetration depth was found to be directly proportional to the supply pressure and volume. High-pressure NFLJIs (620 kPa or above) created maximum force and total work significantly greater than needle injections. Low-pressure NFLJIs (413 kPa), however, produced results similar to those of needle injections. Additionally, high-pressure NFLJIs created jet impingement pressure and maximum jet penetration pressure higher than low-pressure NFLJIs. Pilot RCTs revealed that high-pressure NFLJI caused a high risk of discomfort (60%) and paresthesia (20%); meanwhile, low-pressure NFLJI was less likely to cause complications (0%). The preliminary success rates of MINB from cadavers using NFLJIs and needles were 83.3% and 87.5%. In comparison, those from RCTs are 60% and 70%, respectively. To conclude, NFLJI supply pressure can be adjusted to achieve effective MINB with minimal complications. Furthermore, the cadaver study and pilot RCTs confirmed the feasibility for further non-inferiority RCT.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Pharmaceutics<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ijpharm.2021.121197" target="_blank">https://dx.doi.org/10.1016/j.ijpharm.2021.121197</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_716a517d89c95eec56032843699b781f |
| identifier_str_mv | 10.1016/j.ijpharm.2021.121197 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24339472 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical StudiesQiman Gao (12107281)Anna Henley (12107284)Geoffroy Noël (355057)Zovinar Der Khatchadourian (12107287)Doaa Taqi (9689295)Mohammad Abusamak (10712848)Zixin He (12107278)Swen Grœn (17191330)Rani Taher (17191333)Karim Menassa (17191336)Ana Velly (7307576)Elham Emami (4007807)Luc Mongeau (11189809)Faleh Tamimi (2867255)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesDental anesthesiaMental nerveJet injectionsPilot studiesFeasibility studiesRandomized controlled trialParesthesia<p dir="ltr">The present study aimed to optimize Needle-Free Liquid Jet Injection (NFLJI) for Mental Incisive Nerve Blocks (MINB) and evaluate its clinical safety and feasibility. A MINB protocol was developed and optimized by series of NFLJI experiments in soft tissue phantoms and cadavers, then validated in two pilot Randomized Controlled Trials (RCT). The NFLJI penetration depth was found to be directly proportional to the supply pressure and volume. High-pressure NFLJIs (620 kPa or above) created maximum force and total work significantly greater than needle injections. Low-pressure NFLJIs (413 kPa), however, produced results similar to those of needle injections. Additionally, high-pressure NFLJIs created jet impingement pressure and maximum jet penetration pressure higher than low-pressure NFLJIs. Pilot RCTs revealed that high-pressure NFLJI caused a high risk of discomfort (60%) and paresthesia (20%); meanwhile, low-pressure NFLJI was less likely to cause complications (0%). The preliminary success rates of MINB from cadavers using NFLJIs and needles were 83.3% and 87.5%. In comparison, those from RCTs are 60% and 70%, respectively. To conclude, NFLJI supply pressure can be adjusted to achieve effective MINB with minimal complications. Furthermore, the cadaver study and pilot RCTs confirmed the feasibility for further non-inferiority RCT.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Pharmaceutics<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ijpharm.2021.121197" target="_blank">https://dx.doi.org/10.1016/j.ijpharm.2021.121197</a></p>2021-11-20T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ijpharm.2021.121197https://figshare.com/articles/journal_contribution/Needle-free_Mental_Incisive_Nerve_Block_In_vitro_Cadaveric_and_Pilot_Clinical_Studies/24339472CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/243394722021-11-20T00:00:00Z |
| spellingShingle | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies Qiman Gao (12107281) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Dental anesthesia Mental nerve Jet injections Pilot studies Feasibility studies Randomized controlled trial Paresthesia |
| status_str | publishedVersion |
| title | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies |
| title_full | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies |
| title_fullStr | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies |
| title_full_unstemmed | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies |
| title_short | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies |
| title_sort | Needle-free Mental Incisive Nerve Block: In vitro, Cadaveric, and Pilot Clinical Studies |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Dental anesthesia Mental nerve Jet injections Pilot studies Feasibility studies Randomized controlled trial Paresthesia |