ATM Inhibitors in Cancer Radiotherapy: Mechanisms, Clinical Development, and Future Directions
<p>Ataxia-telangiectasia mutated (ATM) kinase plays a pivotal role in the cellular response to DNA damage. Under normal conditions, ATM acts as a tumor suppressor by regulating pathways that lead to apoptosis and cell cycle arrest via effectors like p53, p21, CHK1, and CHK2. Paradoxically, in...
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2025
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