Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis
<h3 dir="ltr">Background</h3><p dir="ltr">Recurrence of hepatic hydatid cysts after laparoscopic surgery poses a significant challenge in pediatric patients. The administration of albendazole therapy pre- and post-operatively is proposed to reduce recurrence rat...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , |
| Published: |
2025
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513531591786496 |
|---|---|
| author | Marwa Messaoud (22827959) |
| author2 | Amani N. Alansari (19743643) Radhouene Ben Salah (22827962) Sami Sfar (22827965) Basma Haggui (22827968) Amine Ksia (16001677) Mongi Mekki (22827971) Lassaad Sahnoun (22827974) |
| author2_role | author author author author author author author |
| author_facet | Marwa Messaoud (22827959) Amani N. Alansari (19743643) Radhouene Ben Salah (22827962) Sami Sfar (22827965) Basma Haggui (22827968) Amine Ksia (16001677) Mongi Mekki (22827971) Lassaad Sahnoun (22827974) |
| author_role | author |
| dc.creator.none.fl_str_mv | Marwa Messaoud (22827959) Amani N. Alansari (19743643) Radhouene Ben Salah (22827962) Sami Sfar (22827965) Basma Haggui (22827968) Amine Ksia (16001677) Mongi Mekki (22827971) Lassaad Sahnoun (22827974) |
| dc.date.none.fl_str_mv | 2025-07-10T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00464-025-11965-1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Pediatric_hepatic_hydatid_cysts_recurrence_risk_factors_following_laparoscopic_surgery_a_16-year_cohort_analysis/30860063 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Paediatrics Health sciences Epidemiology Public health Hydatid cyst Liver Pediatric Laparoscopy Recurrence Albendazole |
| dc.title.none.fl_str_mv | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3 dir="ltr">Background</h3><p dir="ltr">Recurrence of hepatic hydatid cysts after laparoscopic surgery poses a significant challenge in pediatric patients. The administration of albendazole therapy pre- and post-operatively is proposed to reduce recurrence rates, yet its impact requires further investigation. This study aims to identify predictive factors associated with recurrence of hepatic hydatid cysts in children following laparoscopic surgery, focusing on cyst characteristics and perioperative albendazole therapy.</p><h3 dir="ltr">Methods</h3><p dir="ltr">A retrospective cross-sectional analytical study was conducted using medical records of pediatric patients under 16 years of age who underwent laparoscopic surgery for hepatic hydatid cysts between 2006 and 2021. Collected data included patient demographics, cyst characteristics (size, location, and number), preoperative and postoperative albendazole therapy, surgical duration, and intraoperative complications. Logistic regression analysis was used to identify factors associated with cyst recurrence during the follow-up period, with statistical significance set at p < 0.05.</p><h3 dir="ltr">Results</h3><p dir="ltr">A total of 152 pediatric patients were included, with a mean age of 7.9 ± 3.3 years. The recurrence rate was 12% (<i>n</i>= 18). In multivariate analysis, longer surgical duration (HR = 1.02; 95% CI 1.00–1.03; <i>p</i> = 0.013) and cysts located outside liver segment II (HR = 0.11; 95% CI 0.01–0.9; <i>p</i> = 0.039) were independently associated with recurrence. Albendazole therapy, administered pre- or post-operatively, was more frequent in the non-recurrence group but did not reach statistical significance. No cases of peritoneal hydatidosis were recorded during follow-up.</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">Key predictors of post-laparoscopy recurrence included extended surgical duration and cyst location. Although perioperative albendazole therapy was more frequent in the non-recurrence group, it did not reach statistical significance in reducing recurrence rates. These findings highlight the importance of tailored surgical approaches and careful postoperative monitoring to improve patient outcomes.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Surgical Endoscopy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00464-025-11965-1" target="_blank">https://dx.doi.org/10.1007/s00464-025-11965-1</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_71b6ea6316c8b5bd42b09c6f7b032c3a |
| identifier_str_mv | 10.1007/s00464-025-11965-1 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30860063 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysisMarwa Messaoud (22827959)Amani N. Alansari (19743643)Radhouene Ben Salah (22827962)Sami Sfar (22827965)Basma Haggui (22827968)Amine Ksia (16001677)Mongi Mekki (22827971)Lassaad Sahnoun (22827974)Biomedical and clinical sciencesPaediatricsHealth sciencesEpidemiologyPublic healthHydatid cystLiverPediatricLaparoscopyRecurrenceAlbendazole<h3 dir="ltr">Background</h3><p dir="ltr">Recurrence of hepatic hydatid cysts after laparoscopic surgery poses a significant challenge in pediatric patients. The administration of albendazole therapy pre- and post-operatively is proposed to reduce recurrence rates, yet its impact requires further investigation. This study aims to identify predictive factors associated with recurrence of hepatic hydatid cysts in children following laparoscopic surgery, focusing on cyst characteristics and perioperative albendazole therapy.</p><h3 dir="ltr">Methods</h3><p dir="ltr">A retrospective cross-sectional analytical study was conducted using medical records of pediatric patients under 16 years of age who underwent laparoscopic surgery for hepatic hydatid cysts between 2006 and 2021. Collected data included patient demographics, cyst characteristics (size, location, and number), preoperative and postoperative albendazole therapy, surgical duration, and intraoperative complications. Logistic regression analysis was used to identify factors associated with cyst recurrence during the follow-up period, with statistical significance set at p < 0.05.</p><h3 dir="ltr">Results</h3><p dir="ltr">A total of 152 pediatric patients were included, with a mean age of 7.9 ± 3.3 years. The recurrence rate was 12% (<i>n</i>= 18). In multivariate analysis, longer surgical duration (HR = 1.02; 95% CI 1.00–1.03; <i>p</i> = 0.013) and cysts located outside liver segment II (HR = 0.11; 95% CI 0.01–0.9; <i>p</i> = 0.039) were independently associated with recurrence. Albendazole therapy, administered pre- or post-operatively, was more frequent in the non-recurrence group but did not reach statistical significance. No cases of peritoneal hydatidosis were recorded during follow-up.</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">Key predictors of post-laparoscopy recurrence included extended surgical duration and cyst location. Although perioperative albendazole therapy was more frequent in the non-recurrence group, it did not reach statistical significance in reducing recurrence rates. These findings highlight the importance of tailored surgical approaches and careful postoperative monitoring to improve patient outcomes.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Surgical Endoscopy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00464-025-11965-1" target="_blank">https://dx.doi.org/10.1007/s00464-025-11965-1</a></p>2025-07-10T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00464-025-11965-1https://figshare.com/articles/journal_contribution/Pediatric_hepatic_hydatid_cysts_recurrence_risk_factors_following_laparoscopic_surgery_a_16-year_cohort_analysis/30860063CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/308600632025-07-10T09:00:00Z |
| spellingShingle | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis Marwa Messaoud (22827959) Biomedical and clinical sciences Paediatrics Health sciences Epidemiology Public health Hydatid cyst Liver Pediatric Laparoscopy Recurrence Albendazole |
| status_str | publishedVersion |
| title | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis |
| title_full | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis |
| title_fullStr | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis |
| title_full_unstemmed | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis |
| title_short | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis |
| title_sort | Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery–a 16-year cohort analysis |
| topic | Biomedical and clinical sciences Paediatrics Health sciences Epidemiology Public health Hydatid cyst Liver Pediatric Laparoscopy Recurrence Albendazole |