Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis
<p dir="ltr">Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as t...
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2022
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| _version_ | 1864513506543403008 |
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| author | Susie Shih Yin Huang (9112705) |
| author2 | Darawan Rinchai (742366) Mohammed Toufiq (7251596) Basirudeen Syed Ahamed Kabeer (9676280) Jessica Roelands (7516439) Wouter Hendrickx (44559) Sabri Boughorbel (846228) Davide Bedognetti (2632474) Nicholas Van Panhuys (18282196) Damien Chaussabel (26369) Mathieu Garand (4861942) |
| author2_role | author author author author author author author author author author |
| author_facet | Susie Shih Yin Huang (9112705) Darawan Rinchai (742366) Mohammed Toufiq (7251596) Basirudeen Syed Ahamed Kabeer (9676280) Jessica Roelands (7516439) Wouter Hendrickx (44559) Sabri Boughorbel (846228) Davide Bedognetti (2632474) Nicholas Van Panhuys (18282196) Damien Chaussabel (26369) Mathieu Garand (4861942) |
| author_role | author |
| dc.creator.none.fl_str_mv | Susie Shih Yin Huang (9112705) Darawan Rinchai (742366) Mohammed Toufiq (7251596) Basirudeen Syed Ahamed Kabeer (9676280) Jessica Roelands (7516439) Wouter Hendrickx (44559) Sabri Boughorbel (846228) Davide Bedognetti (2632474) Nicholas Van Panhuys (18282196) Damien Chaussabel (26369) Mathieu Garand (4861942) |
| dc.date.none.fl_str_mv | 2022-02-17T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/jcmm.17240 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Transcriptomic_profile_investigations_highlight_a_putative_role_for_NUDT16_in_sepsis/26889124 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Immunology Sepsis Systemic Inflammatory Response Innate Immune System Neutrophils Thrombosis Organ Dysfunction Gene Expression Profile |
| dc.title.none.fl_str_mv | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as thrombosis and organ dysfunction. A better understanding of the modulations of cellular processes in neutrophils and other blood cells during sepsis is needed and can be initiated via transcriptomic profile investigations. To that point, the growing repertoire of publicly accessible transcriptomic datasets serves as a valuable resource for discovering and/or assessing the robustness of biomarkers. We employed systematic literature mining, reductionist approach to gene expression profile and empirical in vitro work to highlight the role of a Nudix hydrolase family member, NUDT16, in sepsis. The relevance and implication of the expression of NUDT16 under septic conditions and the putative functional roles of this enzyme are discussed.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular and Molecular Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/jcmm.17240" target="_blank">https://dx.doi.org/10.1111/jcmm.17240</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_72d9dbbe1c66e0d985dac57cec61b4b2 |
| identifier_str_mv | 10.1111/jcmm.17240 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26889124 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsisSusie Shih Yin Huang (9112705)Darawan Rinchai (742366)Mohammed Toufiq (7251596)Basirudeen Syed Ahamed Kabeer (9676280)Jessica Roelands (7516439)Wouter Hendrickx (44559)Sabri Boughorbel (846228)Davide Bedognetti (2632474)Nicholas Van Panhuys (18282196)Damien Chaussabel (26369)Mathieu Garand (4861942)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesImmunologySepsisSystemic Inflammatory ResponseInnate Immune SystemNeutrophilsThrombosisOrgan DysfunctionGene Expression Profile<p dir="ltr">Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as thrombosis and organ dysfunction. A better understanding of the modulations of cellular processes in neutrophils and other blood cells during sepsis is needed and can be initiated via transcriptomic profile investigations. To that point, the growing repertoire of publicly accessible transcriptomic datasets serves as a valuable resource for discovering and/or assessing the robustness of biomarkers. We employed systematic literature mining, reductionist approach to gene expression profile and empirical in vitro work to highlight the role of a Nudix hydrolase family member, NUDT16, in sepsis. The relevance and implication of the expression of NUDT16 under septic conditions and the putative functional roles of this enzyme are discussed.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular and Molecular Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/jcmm.17240" target="_blank">https://dx.doi.org/10.1111/jcmm.17240</a></p>2022-02-17T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/jcmm.17240https://figshare.com/articles/journal_contribution/Transcriptomic_profile_investigations_highlight_a_putative_role_for_NUDT16_in_sepsis/26889124CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/268891242022-02-17T09:00:00Z |
| spellingShingle | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis Susie Shih Yin Huang (9112705) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Immunology Sepsis Systemic Inflammatory Response Innate Immune System Neutrophils Thrombosis Organ Dysfunction Gene Expression Profile |
| status_str | publishedVersion |
| title | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
| title_full | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
| title_fullStr | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
| title_full_unstemmed | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
| title_short | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
| title_sort | Transcriptomic profile investigations highlight a putative role for NUDT16 in sepsis |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Immunology Sepsis Systemic Inflammatory Response Innate Immune System Neutrophils Thrombosis Organ Dysfunction Gene Expression Profile |