Potential Adverse Effects of Resveratrol: A Literature Review
<p dir="ltr">Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, s...
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2020
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| الموضوعات: | |
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| _version_ | 1864513554536726528 |
|---|---|
| author | Abdullah Shaito (17746962) |
| author2 | Anna Maria Posadino (13917535) Nadin Younes (4863280) Hiba Hasan (6109148) Sarah Halabi (20318316) Dalal Alhababi (20318319) Anjud Al-Mohannadi (18628744) Wael M Abdel-Rahman (20318322) Ali H. Eid (5461829) Gheyath K. Nasrallah (9200525) Gianfranco Pintus (91638) |
| author2_role | author author author author author author author author author author |
| author_facet | Abdullah Shaito (17746962) Anna Maria Posadino (13917535) Nadin Younes (4863280) Hiba Hasan (6109148) Sarah Halabi (20318316) Dalal Alhababi (20318319) Anjud Al-Mohannadi (18628744) Wael M Abdel-Rahman (20318322) Ali H. Eid (5461829) Gheyath K. Nasrallah (9200525) Gianfranco Pintus (91638) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdullah Shaito (17746962) Anna Maria Posadino (13917535) Nadin Younes (4863280) Hiba Hasan (6109148) Sarah Halabi (20318316) Dalal Alhababi (20318319) Anjud Al-Mohannadi (18628744) Wael M Abdel-Rahman (20318322) Ali H. Eid (5461829) Gheyath K. Nasrallah (9200525) Gianfranco Pintus (91638) |
| dc.date.none.fl_str_mv | 2020-03-18T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms21062084 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Potential_Adverse_Effects_of_Resveratrol_A_Literature_Review/27896202 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences resveratrol biphasic anticancer reactive oxygen species (ROS) oxidative DNA damage antioxidant effects pro-oxidant effects |
| dc.title.none.fl_str_mv | Potential Adverse Effects of Resveratrol: A Literature Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms21062084" target="_blank">https://dx.doi.org/10.3390/ijms21062084</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_72e56082d2c92949fae68c2d2e909f9e |
| identifier_str_mv | 10.3390/ijms21062084 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27896202 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Potential Adverse Effects of Resveratrol: A Literature ReviewAbdullah Shaito (17746962)Anna Maria Posadino (13917535)Nadin Younes (4863280)Hiba Hasan (6109148)Sarah Halabi (20318316)Dalal Alhababi (20318319)Anjud Al-Mohannadi (18628744)Wael M Abdel-Rahman (20318322)Ali H. Eid (5461829)Gheyath K. Nasrallah (9200525)Gianfranco Pintus (91638)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesresveratrolbiphasicanticancerreactive oxygen species (ROS)oxidative DNA damageantioxidant effectspro-oxidant effects<p dir="ltr">Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms21062084" target="_blank">https://dx.doi.org/10.3390/ijms21062084</a></p>2020-03-18T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms21062084https://figshare.com/articles/journal_contribution/Potential_Adverse_Effects_of_Resveratrol_A_Literature_Review/27896202CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/278962022020-03-18T03:00:00Z |
| spellingShingle | Potential Adverse Effects of Resveratrol: A Literature Review Abdullah Shaito (17746962) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences resveratrol biphasic anticancer reactive oxygen species (ROS) oxidative DNA damage antioxidant effects pro-oxidant effects |
| status_str | publishedVersion |
| title | Potential Adverse Effects of Resveratrol: A Literature Review |
| title_full | Potential Adverse Effects of Resveratrol: A Literature Review |
| title_fullStr | Potential Adverse Effects of Resveratrol: A Literature Review |
| title_full_unstemmed | Potential Adverse Effects of Resveratrol: A Literature Review |
| title_short | Potential Adverse Effects of Resveratrol: A Literature Review |
| title_sort | Potential Adverse Effects of Resveratrol: A Literature Review |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences resveratrol biphasic anticancer reactive oxygen species (ROS) oxidative DNA damage antioxidant effects pro-oxidant effects |