Comparison of Siemens Rapidlab 1200 blood gas analyzers and Beckman Coulter AU680 laboratory auto analyzers for sodium, potassium, hemoglobin and hematocrit parameters in emergency departments patients
<p dir="ltr">Blood gas analyzers (BGAs) offer rapid results and operational convenience in emergency settings, whereas laboratory auto analyzers (LAAs) remain the reference standard despite slower processing. This study compared BGA and LAA measurements of sodium (Na), potassium (K),...
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2025
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| Summary: | <p dir="ltr">Blood gas analyzers (BGAs) offer rapid results and operational convenience in emergency settings, whereas laboratory auto analyzers (LAAs) remain the reference standard despite slower processing. This study compared BGA and LAA measurements of sodium (Na), potassium (K), hemoglobin (Hb), and hematocrit (Hct). A secondary aim was to evaluate their agreement across acid–base subgroups and in cases of severe acidosis. This study included ≥18 years patients from January 1 to June 30, 2024. BGA and LAA results were compared overall and across acid–base subgroups. Patients with pH <7.20 were analyzed separately as the severe acidosis group. Bland–Altman analysis showed the following mean differences and 95% limits of agreement: Na, 1.36 ± 2.33 mmol/L (−3.21 to 5.92); K, 0.221 ± 0.197 mmol/L (−0.166 to 0.607); Hb, 0.531 ± 0.649 g/dL (−0.742 to 1.804); and Hct, 1.68% ± 2.60 (−3.42 to 6.78). At clinical decision thresholds, BGA demonstrated varying diagnostic performance with sensitivities and specificities of 56.9% and 95.8% for hyponatremia, 67.5% and 98.7% for hypernatremia, 95.4% and 95.6% for hypokalemia, 48.7% and 99.8% for hyperkalemia, and 73.4% and 99.9% for transfusion decisions, respectively. In patients with severe acidosis, correlations remained strong, though agreement limits were notably wider. BGA-derived K values showed acceptable agreement with LAA and may be used interchangeably. Hb and Hct did not meet agreement criteria, while Na may be acceptable with clinical correlation. In severe acidosis, none of the parameters achieved acceptable agreement, indicating that BGA results should be interpreted with caution in this subgroup.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Scandinavian Journal of Clinical and Laboratory Investigation<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/00365513.2025.2582209" target="_blank">https://dx.doi.org/10.1080/00365513.2025.2582209</a></p> |
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