Role of ESR Pathway Genes in Breast Cancer: A Review
<p dir="ltr">Breast cancer is the leading cause of death in women. Prognosis of breast cancer is often pessimistic because the tumors are prone to metastasizing to the bone, brain, and lung. The estrogen signaling receptor (ESR) pathway contains 39 main genes and proteins which makes...
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| مؤلفون آخرون: | , , |
| منشور في: |
2018
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| _version_ | 1864513522157748224 |
|---|---|
| author | Deepak Kumar (63095) |
| author2 | Marilyn Rae Myers (23277241) Ussama Al Homsi (14442150) Valentin Ilyin (2368732) |
| author2_role | author author author |
| author_facet | Deepak Kumar (63095) Marilyn Rae Myers (23277241) Ussama Al Homsi (14442150) Valentin Ilyin (2368732) |
| author_role | author |
| dc.creator.none.fl_str_mv | Deepak Kumar (63095) Marilyn Rae Myers (23277241) Ussama Al Homsi (14442150) Valentin Ilyin (2368732) |
| dc.date.none.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.4236/abcr.2018.72010 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Role_of_ESR_Pathway_Genes_in_Breast_Cancer_A_Review/31446019 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Estrogen Signaling Receptor (ESR) Pathway Breast Cancer ESR Genes Mechanistic Modeling Integrated Study Kyoto Encyclopedia of Genes and Genomes (KEGG) PubMed Literature Survey |
| dc.title.none.fl_str_mv | Role of ESR Pathway Genes in Breast Cancer: A Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Breast cancer is the leading cause of death in women. Prognosis of breast cancer is often pessimistic because the tumors are prone to metastasizing to the bone, brain, and lung. The estrogen signaling receptor (ESR) pathway contains 39 main genes and proteins which makes it one of the larger signaling pathways. Predominately this pathway and the proteins within are involved in breast growth and development, making it a prospective area of study for breast cancer. While the healthy ESR pathway has been constructed and is well established, a mechanistic model of mutated genes of ESR pathway has not been delved upon. Such mutated models could be utilized for selecting combinational targets for drug therapies, as well as elucidating crosstalk between other pathways and feedback mechanisms. To construct the mutated models of the ESR pathway it is imperative to assess what is currently understood in the literature and what inconsistencies exist in order to resolve them. Without this information, a model of the ESR pathway will be unreliable and likely unproductive. This review is the detailed literature survey of the biological studies performed on ESR pathways genes, and their respective roles in breast cancer. Furthermore, the details mentioned in the review can be beneficial for the integrated study of the ESR pathway genes, which includes, structural and dynamics study of the genes products, to have a holistic understanding of the cancer mechanism.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Advances in Breast Cancer Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.4236/abcr.2018.72010" target="_blank">https://dx.doi.org/10.4236/abcr.2018.72010</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_73e7b182225d73c21425202078e22cf6 |
| identifier_str_mv | 10.4236/abcr.2018.72010 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/31446019 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Role of ESR Pathway Genes in Breast Cancer: A ReviewDeepak Kumar (63095)Marilyn Rae Myers (23277241)Ussama Al Homsi (14442150)Valentin Ilyin (2368732)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisEstrogen Signaling Receptor (ESR)PathwayBreast CancerESR GenesMechanistic ModelingIntegrated StudyKyoto Encyclopedia of Genes and Genomes (KEGG)PubMedLiterature Survey<p dir="ltr">Breast cancer is the leading cause of death in women. Prognosis of breast cancer is often pessimistic because the tumors are prone to metastasizing to the bone, brain, and lung. The estrogen signaling receptor (ESR) pathway contains 39 main genes and proteins which makes it one of the larger signaling pathways. Predominately this pathway and the proteins within are involved in breast growth and development, making it a prospective area of study for breast cancer. While the healthy ESR pathway has been constructed and is well established, a mechanistic model of mutated genes of ESR pathway has not been delved upon. Such mutated models could be utilized for selecting combinational targets for drug therapies, as well as elucidating crosstalk between other pathways and feedback mechanisms. To construct the mutated models of the ESR pathway it is imperative to assess what is currently understood in the literature and what inconsistencies exist in order to resolve them. Without this information, a model of the ESR pathway will be unreliable and likely unproductive. This review is the detailed literature survey of the biological studies performed on ESR pathways genes, and their respective roles in breast cancer. Furthermore, the details mentioned in the review can be beneficial for the integrated study of the ESR pathway genes, which includes, structural and dynamics study of the genes products, to have a holistic understanding of the cancer mechanism.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Advances in Breast Cancer Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.4236/abcr.2018.72010" target="_blank">https://dx.doi.org/10.4236/abcr.2018.72010</a></p>2018-01-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.4236/abcr.2018.72010https://figshare.com/articles/journal_contribution/Role_of_ESR_Pathway_Genes_in_Breast_Cancer_A_Review/31446019CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/314460192018-01-01T00:00:00Z |
| spellingShingle | Role of ESR Pathway Genes in Breast Cancer: A Review Deepak Kumar (63095) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Estrogen Signaling Receptor (ESR) Pathway Breast Cancer ESR Genes Mechanistic Modeling Integrated Study Kyoto Encyclopedia of Genes and Genomes (KEGG) PubMed Literature Survey |
| status_str | publishedVersion |
| title | Role of ESR Pathway Genes in Breast Cancer: A Review |
| title_full | Role of ESR Pathway Genes in Breast Cancer: A Review |
| title_fullStr | Role of ESR Pathway Genes in Breast Cancer: A Review |
| title_full_unstemmed | Role of ESR Pathway Genes in Breast Cancer: A Review |
| title_short | Role of ESR Pathway Genes in Breast Cancer: A Review |
| title_sort | Role of ESR Pathway Genes in Breast Cancer: A Review |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Estrogen Signaling Receptor (ESR) Pathway Breast Cancer ESR Genes Mechanistic Modeling Integrated Study Kyoto Encyclopedia of Genes and Genomes (KEGG) PubMed Literature Survey |