MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs)
<h3>Background</h3><p dir="ltr">Post‐traumatic stress disorder (PTSD) is a mental health disorder resulting from exposure to traumatic events, manifesting in various debilitating symptoms. Despite available treatments, many individuals experience inadequate response or si...
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2024
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| _version_ | 1864513540420796416 |
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| author | Ghada Shahrour (13775360) |
| author2 | Kainat Sohail (22224277) Safa Elrais (22224280) Muhammad Hamza Khan (19760909) Javeria Javeid (22107469) Khubaib Samdani (22224283) Hajra Mansoor (22224286) Syed Izhar Hussain (22224289) Dhruvikumari Sharma (22224292) Muhammad Ehsan (2561170) Abdulqadir J. Nashwan (11659453) |
| author2_role | author author author author author author author author author author |
| author_facet | Ghada Shahrour (13775360) Kainat Sohail (22224277) Safa Elrais (22224280) Muhammad Hamza Khan (19760909) Javeria Javeid (22107469) Khubaib Samdani (22224283) Hajra Mansoor (22224286) Syed Izhar Hussain (22224289) Dhruvikumari Sharma (22224292) Muhammad Ehsan (2561170) Abdulqadir J. Nashwan (11659453) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ghada Shahrour (13775360) Kainat Sohail (22224277) Safa Elrais (22224280) Muhammad Hamza Khan (19760909) Javeria Javeid (22107469) Khubaib Samdani (22224283) Hajra Mansoor (22224286) Syed Izhar Hussain (22224289) Dhruvikumari Sharma (22224292) Muhammad Ehsan (2561170) Abdulqadir J. Nashwan (11659453) |
| dc.date.none.fl_str_mv | 2024-10-09T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/npr2.12485 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/MDMA_assisted_psychotherapy_for_the_treatment_of_PTSD_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_RCTs_/30094189 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Health services and systems Public health MDMA-AT meta-analysis post-traumatic stress disorder RCTs |
| dc.title.none.fl_str_mv | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Post‐traumatic stress disorder (PTSD) is a mental health disorder resulting from exposure to traumatic events, manifesting in various debilitating symptoms. Despite available treatments, many individuals experience inadequate response or significant side effects. Previous reviews suggest promising outcomes with MDMA‐assisted psychotherapy (MDMA‐AT), but limitations prompt the need for a comprehensive evaluation.</p><h3>Methods</h3><p dir="ltr">We searched various online databases and registries such as MEDLINE (via PubMed), Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov to retrieve RCTs that fit our inclusion criteria. We performed meta‐analyses using Review Manager by applying a random‐effects model. Dichotomous and continuous outcomes were pooled as risk ratios (RR) and standard mean difference (SMD), respectively.</p><h3>Results</h3><p dir="ltr">Nine studies with a total of 297 participants with PTSD were included in our meta‐analysis. The control group consisted of inactive doses of MDMA (25–40 mg) or placebo. Our meta‐analysis showed that MDMA‐AT led to a significant reduction in the Clinician‐Administered PTSD Scale for DSM‐5 (CAPS‐5) severity scores as compared to the control group (SMD −1.10, 95% CI: −1.62 to −0.59). More patients in the MDMA‐AT group exhibited significant response (RR 1.59, 95% CI: 1.22, 2.08) and remission (RR 2.32, 95% CI: 1.47 to 3.66) as compared to patients in the control group. There was no significant difference regarding the incidence of ≥1 treatment‐emergent adverse events (TEAE), ≥1 severe TEAE, and suicidal ideation between the two groups.</p><h3>Conclusion</h3><p dir="ltr">MDMA‐AT demonstrates significant efficacy in improving PTSD symptoms, enhancing both response and remission rates in individuals with chronic, treatment‐resistant PTSD, while maintaining a favorable safety profile.</p><h2>Other Information</h2><p dir="ltr">Published in: Neuropsychopharmacology Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/npr2.12485" target="_blank">https://dx.doi.org/10.1002/npr2.12485</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_74cae90a32d76f4534a0fc6e8c67f8c6 |
| identifier_str_mv | 10.1002/npr2.12485 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30094189 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs)Ghada Shahrour (13775360)Kainat Sohail (22224277)Safa Elrais (22224280)Muhammad Hamza Khan (19760909)Javeria Javeid (22107469)Khubaib Samdani (22224283)Hajra Mansoor (22224286)Syed Izhar Hussain (22224289)Dhruvikumari Sharma (22224292)Muhammad Ehsan (2561170)Abdulqadir J. Nashwan (11659453)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesHealth sciencesHealth services and systemsPublic healthMDMA-ATmeta-analysispost-traumatic stress disorderRCTs<h3>Background</h3><p dir="ltr">Post‐traumatic stress disorder (PTSD) is a mental health disorder resulting from exposure to traumatic events, manifesting in various debilitating symptoms. Despite available treatments, many individuals experience inadequate response or significant side effects. Previous reviews suggest promising outcomes with MDMA‐assisted psychotherapy (MDMA‐AT), but limitations prompt the need for a comprehensive evaluation.</p><h3>Methods</h3><p dir="ltr">We searched various online databases and registries such as MEDLINE (via PubMed), Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov to retrieve RCTs that fit our inclusion criteria. We performed meta‐analyses using Review Manager by applying a random‐effects model. Dichotomous and continuous outcomes were pooled as risk ratios (RR) and standard mean difference (SMD), respectively.</p><h3>Results</h3><p dir="ltr">Nine studies with a total of 297 participants with PTSD were included in our meta‐analysis. The control group consisted of inactive doses of MDMA (25–40 mg) or placebo. Our meta‐analysis showed that MDMA‐AT led to a significant reduction in the Clinician‐Administered PTSD Scale for DSM‐5 (CAPS‐5) severity scores as compared to the control group (SMD −1.10, 95% CI: −1.62 to −0.59). More patients in the MDMA‐AT group exhibited significant response (RR 1.59, 95% CI: 1.22, 2.08) and remission (RR 2.32, 95% CI: 1.47 to 3.66) as compared to patients in the control group. There was no significant difference regarding the incidence of ≥1 treatment‐emergent adverse events (TEAE), ≥1 severe TEAE, and suicidal ideation between the two groups.</p><h3>Conclusion</h3><p dir="ltr">MDMA‐AT demonstrates significant efficacy in improving PTSD symptoms, enhancing both response and remission rates in individuals with chronic, treatment‐resistant PTSD, while maintaining a favorable safety profile.</p><h2>Other Information</h2><p dir="ltr">Published in: Neuropsychopharmacology Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/npr2.12485" target="_blank">https://dx.doi.org/10.1002/npr2.12485</a></p>2024-10-09T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/npr2.12485https://figshare.com/articles/journal_contribution/MDMA_assisted_psychotherapy_for_the_treatment_of_PTSD_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_RCTs_/30094189CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/300941892024-10-09T03:00:00Z |
| spellingShingle | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) Ghada Shahrour (13775360) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Health services and systems Public health MDMA-AT meta-analysis post-traumatic stress disorder RCTs |
| status_str | publishedVersion |
| title | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) |
| title_full | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) |
| title_fullStr | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) |
| title_full_unstemmed | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) |
| title_short | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) |
| title_sort | MDMA‐assisted psychotherapy for the treatment of PTSD: A systematic review and meta‐analysis of randomized controlled trials (RCTs) |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Health services and systems Public health MDMA-AT meta-analysis post-traumatic stress disorder RCTs |