Three cases of chronic photodermatitis successfully treated with upadacitinib
<p dir="ltr">Photodermatoses represent a varied collection of skin disorders characterized by cutaneous reactions provoked by exposure to ultraviolet radiation. The disease mechanism is based on an immune-mediated delayed hypersensitivity reaction. Clinical presentation of patients w...
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| مؤلفون آخرون: | , , , , , , , , , , , , |
| منشور في: |
2025
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إضافة وسم
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| _version_ | 1864513531968225280 |
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| author | Hissa Al-Marri (22827287) |
| author2 | Wadha Al-Shafi (16791427) Mohammed Al-Abdula (22827290) Mohammed Al-Jaber (22827293) Ayda AlHammadi (17876903) Aysha Al-Malki (22502879) Hanof Ahmed (16494866) Maryam Al-Jaidah (22827296) Fatima Al-Khawaja (22827299) Seena Manjooran (22502882) Febu Joy (19325689) Fareed Ahmad (134672) Joerg Buddenkotte (6293584) Martin Steinhoff (5340194) |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Hissa Al-Marri (22827287) Wadha Al-Shafi (16791427) Mohammed Al-Abdula (22827290) Mohammed Al-Jaber (22827293) Ayda AlHammadi (17876903) Aysha Al-Malki (22502879) Hanof Ahmed (16494866) Maryam Al-Jaidah (22827296) Fatima Al-Khawaja (22827299) Seena Manjooran (22502882) Febu Joy (19325689) Fareed Ahmad (134672) Joerg Buddenkotte (6293584) Martin Steinhoff (5340194) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hissa Al-Marri (22827287) Wadha Al-Shafi (16791427) Mohammed Al-Abdula (22827290) Mohammed Al-Jaber (22827293) Ayda AlHammadi (17876903) Aysha Al-Malki (22502879) Hanof Ahmed (16494866) Maryam Al-Jaidah (22827296) Fatima Al-Khawaja (22827299) Seena Manjooran (22502882) Febu Joy (19325689) Fareed Ahmad (134672) Joerg Buddenkotte (6293584) Martin Steinhoff (5340194) |
| dc.date.none.fl_str_mv | 2025-07-23T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1093/skinhd/vzaf049 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Three_cases_of_chronic_photodermatitis_successfully_treated_with_upadacitinib/30859637 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology Pharmacology and pharmaceutical sciences Photodermatoses Chronic Photodermatitis Ultraviolet-Induced Skin Disorders Immune-Mediated Hypersensitivity |
| dc.title.none.fl_str_mv | Three cases of chronic photodermatitis successfully treated with upadacitinib |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Photodermatoses represent a varied collection of skin disorders characterized by cutaneous reactions provoked by exposure to ultraviolet radiation. The disease mechanism is based on an immune-mediated delayed hypersensitivity reaction. Clinical presentation of patients with photodermatosis includes pigmentary changes, erythema and/or lichenification, with interindividual differences in lesion morphology and distribution. Most patients report associated symptoms of burning sensation and itchiness as their chief complaint, severely affecting their quality of life. Management of photodermatoses involves both preventive measures and medical management applying topical steroids and calcineurin inhibitors, or systemic immunosuppressives, with variable degree of success and adverse events. Here, we report three cases of chronic photodermatitis treated with upadacitinib, a selective Janus kinase 1 inhibitor, as monotherapy, which resulted in fast, significant and sustainable improvement of signs and symptoms, with a favourable safety and tolerability profile.</p><h2>Other Information</h2><p dir="ltr">Published in: Skin Health and Disease<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/skinhd/vzaf049" target="_blank">https://dx.doi.org/10.1093/skinhd/vzaf049</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_763fdc3f8e6785a12e88f2fd82641963 |
| identifier_str_mv | 10.1093/skinhd/vzaf049 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30859637 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Three cases of chronic photodermatitis successfully treated with upadacitinibHissa Al-Marri (22827287)Wadha Al-Shafi (16791427)Mohammed Al-Abdula (22827290)Mohammed Al-Jaber (22827293)Ayda AlHammadi (17876903)Aysha Al-Malki (22502879)Hanof Ahmed (16494866)Maryam Al-Jaidah (22827296)Fatima Al-Khawaja (22827299)Seena Manjooran (22502882)Febu Joy (19325689)Fareed Ahmad (134672)Joerg Buddenkotte (6293584)Martin Steinhoff (5340194)Biomedical and clinical sciencesClinical sciencesImmunologyPharmacology and pharmaceutical sciencesPhotodermatosesChronic PhotodermatitisUltraviolet-InducedSkin DisordersImmune-Mediated Hypersensitivity<p dir="ltr">Photodermatoses represent a varied collection of skin disorders characterized by cutaneous reactions provoked by exposure to ultraviolet radiation. The disease mechanism is based on an immune-mediated delayed hypersensitivity reaction. Clinical presentation of patients with photodermatosis includes pigmentary changes, erythema and/or lichenification, with interindividual differences in lesion morphology and distribution. Most patients report associated symptoms of burning sensation and itchiness as their chief complaint, severely affecting their quality of life. Management of photodermatoses involves both preventive measures and medical management applying topical steroids and calcineurin inhibitors, or systemic immunosuppressives, with variable degree of success and adverse events. Here, we report three cases of chronic photodermatitis treated with upadacitinib, a selective Janus kinase 1 inhibitor, as monotherapy, which resulted in fast, significant and sustainable improvement of signs and symptoms, with a favourable safety and tolerability profile.</p><h2>Other Information</h2><p dir="ltr">Published in: Skin Health and Disease<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/skinhd/vzaf049" target="_blank">https://dx.doi.org/10.1093/skinhd/vzaf049</a></p>2025-07-23T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1093/skinhd/vzaf049https://figshare.com/articles/journal_contribution/Three_cases_of_chronic_photodermatitis_successfully_treated_with_upadacitinib/30859637CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/308596372025-07-23T09:00:00Z |
| spellingShingle | Three cases of chronic photodermatitis successfully treated with upadacitinib Hissa Al-Marri (22827287) Biomedical and clinical sciences Clinical sciences Immunology Pharmacology and pharmaceutical sciences Photodermatoses Chronic Photodermatitis Ultraviolet-Induced Skin Disorders Immune-Mediated Hypersensitivity |
| status_str | publishedVersion |
| title | Three cases of chronic photodermatitis successfully treated with upadacitinib |
| title_full | Three cases of chronic photodermatitis successfully treated with upadacitinib |
| title_fullStr | Three cases of chronic photodermatitis successfully treated with upadacitinib |
| title_full_unstemmed | Three cases of chronic photodermatitis successfully treated with upadacitinib |
| title_short | Three cases of chronic photodermatitis successfully treated with upadacitinib |
| title_sort | Three cases of chronic photodermatitis successfully treated with upadacitinib |
| topic | Biomedical and clinical sciences Clinical sciences Immunology Pharmacology and pharmaceutical sciences Photodermatoses Chronic Photodermatitis Ultraviolet-Induced Skin Disorders Immune-Mediated Hypersensitivity |