Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction
<h3>Background</h3><p dir="ltr">Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. Furthermore, it is strongly associated with other metabolic syndrome variables, such as hyperte...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , |
| منشور في: |
2017
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| الموضوعات: | |
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| _version_ | 1864513556574109696 |
|---|---|
| author | Daniel E. Platt (13982757) |
| author2 | Essa Hariri (4638289) Pascale Salameh (640169) Mahmoud Merhi (4638298) Nada Sabbah (4638295) Mariana Helou (12477762) Francis Mouzaya (19725421) Rita Nemer (19725424) Yasser Al-Sarraj (11721425) Hatem El-Shanti (492142) Antoine B. Abchee (19686070) Pierre A. Zalloua (176059) |
| author2_role | author author author author author author author author author author author |
| author_facet | Daniel E. Platt (13982757) Essa Hariri (4638289) Pascale Salameh (640169) Mahmoud Merhi (4638298) Nada Sabbah (4638295) Mariana Helou (12477762) Francis Mouzaya (19725421) Rita Nemer (19725424) Yasser Al-Sarraj (11721425) Hatem El-Shanti (492142) Antoine B. Abchee (19686070) Pierre A. Zalloua (176059) |
| author_role | author |
| dc.creator.none.fl_str_mv | Daniel E. Platt (13982757) Essa Hariri (4638289) Pascale Salameh (640169) Mahmoud Merhi (4638298) Nada Sabbah (4638295) Mariana Helou (12477762) Francis Mouzaya (19725421) Rita Nemer (19725424) Yasser Al-Sarraj (11721425) Hatem El-Shanti (492142) Antoine B. Abchee (19686070) Pierre A. Zalloua (176059) |
| dc.date.none.fl_str_mv | 2017-03-21T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s13098-017-0218-0 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Type_II_diabetes_mellitus_and_hyperhomocysteinemia_a_complex_interaction/27088036 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Health sciences Epidemiology Homocysteine MTHFR C667T Diabetes mellitus |
| dc.title.none.fl_str_mv | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. Furthermore, it is strongly associated with other metabolic syndrome variables, such as hypertension, which is correlated with type II diabetes mellitus (T2DM). Studies on T2DM in relation to Hc levels have shown both positive and negative associations. The aim of the present study is to examine the relationship between Hc levels and risk of T2DM in the Lebanese population.</p><h3>Methods</h3><p dir="ltr">We sought to identify whether Hc associates positively or negatively with diabetes in a case–control study, where 2755 subjects enrolled from patients who had been catheterized for coronary artery diagnosis and treatment. We further sought to identify whether the gene variant MTHFR 667C>T is associated with T2DM, and how Hc and MTHFR 667C>T also impact other correlates of T2DM, including the widely used diuretics in this study population.</p><h3>Results</h3><p dir="ltr">We found that Hc levels were significantly reduced among subjects with diabetes compared to those without diabetes when adjusted for all potential confounders (OR 0.640; 95% CI [0.44–0.92]; <i>p</i> = 0.0200). The associations between Hc levels and other variates contradicted the result: hypertension associates positively with high Hc levels, and with T2DM. The MTHFR 667C>T only associated significantly with high Hc levels.</p><h3>Conclusion</h3><p dir="ltr">These results suggest population-specific variations among a range of mechanisms that modulate the association of Hc and T2DM, providing a probe for future studies.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetology & Metabolic Syndrome<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" rel="noreferrer noopener" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> <br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13098-017-0218-0" target="_blank">https://dx.doi.org/10.1186/s13098-017-0218-0</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7749a3b626af78876b84f0f462c9b0b9 |
| identifier_str_mv | 10.1186/s13098-017-0218-0 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27088036 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Type II diabetes mellitus and hyperhomocysteinemia: a complex interactionDaniel E. Platt (13982757)Essa Hariri (4638289)Pascale Salameh (640169)Mahmoud Merhi (4638298)Nada Sabbah (4638295)Mariana Helou (12477762)Francis Mouzaya (19725421)Rita Nemer (19725424)Yasser Al-Sarraj (11721425)Hatem El-Shanti (492142)Antoine B. Abchee (19686070)Pierre A. Zalloua (176059)Health sciencesEpidemiologyHomocysteineMTHFR C667TDiabetes mellitus<h3>Background</h3><p dir="ltr">Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. Furthermore, it is strongly associated with other metabolic syndrome variables, such as hypertension, which is correlated with type II diabetes mellitus (T2DM). Studies on T2DM in relation to Hc levels have shown both positive and negative associations. The aim of the present study is to examine the relationship between Hc levels and risk of T2DM in the Lebanese population.</p><h3>Methods</h3><p dir="ltr">We sought to identify whether Hc associates positively or negatively with diabetes in a case–control study, where 2755 subjects enrolled from patients who had been catheterized for coronary artery diagnosis and treatment. We further sought to identify whether the gene variant MTHFR 667C>T is associated with T2DM, and how Hc and MTHFR 667C>T also impact other correlates of T2DM, including the widely used diuretics in this study population.</p><h3>Results</h3><p dir="ltr">We found that Hc levels were significantly reduced among subjects with diabetes compared to those without diabetes when adjusted for all potential confounders (OR 0.640; 95% CI [0.44–0.92]; <i>p</i> = 0.0200). The associations between Hc levels and other variates contradicted the result: hypertension associates positively with high Hc levels, and with T2DM. The MTHFR 667C>T only associated significantly with high Hc levels.</p><h3>Conclusion</h3><p dir="ltr">These results suggest population-specific variations among a range of mechanisms that modulate the association of Hc and T2DM, providing a probe for future studies.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetology & Metabolic Syndrome<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" rel="noreferrer noopener" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> <br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13098-017-0218-0" target="_blank">https://dx.doi.org/10.1186/s13098-017-0218-0</a></p>2017-03-21T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s13098-017-0218-0https://figshare.com/articles/journal_contribution/Type_II_diabetes_mellitus_and_hyperhomocysteinemia_a_complex_interaction/27088036CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/270880362017-03-21T03:00:00Z |
| spellingShingle | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction Daniel E. Platt (13982757) Health sciences Epidemiology Homocysteine MTHFR C667T Diabetes mellitus |
| status_str | publishedVersion |
| title | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction |
| title_full | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction |
| title_fullStr | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction |
| title_full_unstemmed | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction |
| title_short | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction |
| title_sort | Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction |
| topic | Health sciences Epidemiology Homocysteine MTHFR C667T Diabetes mellitus |