A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing
<p dir="ltr">Impaired wound healing is a major healthcare problem in patients with diabetes often resulting in gangrene, microbial infection and amputation of affected limb. The delay or absence in healing process arises from several abnormalities, among them chronic hypoxia is a maj...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2023
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إضافة وسم
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| _version_ | 1864513526397140992 |
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| author | Asad Ullah (4524541) |
| author2 | Abdulla Al Mamun (8773013) Midhat Batool Zaidi (18024226) Talat Roome (4806630) Anwarul Hasan (1332066) |
| author2_role | author author author author |
| author_facet | Asad Ullah (4524541) Abdulla Al Mamun (8773013) Midhat Batool Zaidi (18024226) Talat Roome (4806630) Anwarul Hasan (1332066) |
| author_role | author |
| dc.creator.none.fl_str_mv | Asad Ullah (4524541) Abdulla Al Mamun (8773013) Midhat Batool Zaidi (18024226) Talat Roome (4806630) Anwarul Hasan (1332066) |
| dc.date.none.fl_str_mv | 2023-09-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.biopha.2023.115156 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_calcium_peroxide_incorporated_oxygen_releasing_chitosan-PVA_patch_for_Diabetic_wound_healing/25287385 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Materials engineering Nanotechnology Diabetic wound healing Chronic hypoxia Oxygen releasing materials |
| dc.title.none.fl_str_mv | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Impaired wound healing is a major healthcare problem in patients with diabetes often resulting in gangrene, microbial infection and amputation of affected limb. The delay or absence in healing process arises from several abnormalities, among them chronic hypoxia is a major concern due to its associated issues such as lack of collagen deposition, epithelization, fibroplasia, angiogenesis, and resistance to infections at the wound site. To address hypoxia, delivery of oxygen at the wound site through oxygen releasing agents have been proven to be effective therapeutics. Several oxygen releasing nanoparticles such as Sodium Percarbonate (SPC), Calcium Peroxide (CPO), Hydrogen Peroxide, Magnesium Peroxide (MPO) have been investigated in wound healing application. However, the uncontrolled/burst release of these nanotherapeutic agents and its accompanied cytotoxicity pose a barrier in expediting the healing process. In this study, a Chitosan-Polyvinyl alcohol (CS-PVA) based hydrogel containing oxygen releasing nanoparticle, calcium peroxide (CPO) was constructed to provide a slow and sustained delivery of oxygen for at least 5 days. In-vitro cell culture studies with this material using fibroblast and endothelial cell line exhibited improved biocompatibility, cell viability and enhanced proliferation in comparison with the control group. Additionally, cell migration study using scratch assay method showed superior cell migration ability of our proposed materials. Furthermore, In vivo study using diabetic rat model showed accelerated wound closure rate compared to untreated control wounds.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2023.115156" rel="noreferrer" target="_blank">https://dx.doi.org/10.1016/j.biopha.2023.115156</a><br>Additional institutions affiliated with: Pak-Qatar Family Takaful Limited (PQFTL), Dow University of Health Sciences Qatar and Dow International Medical College – DUHSQ</p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_77e316523f6ad65236b3c0dbeddd024a |
| identifier_str_mv | 10.1016/j.biopha.2023.115156 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25287385 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healingAsad Ullah (4524541)Abdulla Al Mamun (8773013)Midhat Batool Zaidi (18024226)Talat Roome (4806630)Anwarul Hasan (1332066)Biomedical and clinical sciencesMedical biochemistry and metabolomicsPharmacology and pharmaceutical sciencesEngineeringBiomedical engineeringMaterials engineeringNanotechnologyDiabetic wound healingChronic hypoxiaOxygen releasing materials<p dir="ltr">Impaired wound healing is a major healthcare problem in patients with diabetes often resulting in gangrene, microbial infection and amputation of affected limb. The delay or absence in healing process arises from several abnormalities, among them chronic hypoxia is a major concern due to its associated issues such as lack of collagen deposition, epithelization, fibroplasia, angiogenesis, and resistance to infections at the wound site. To address hypoxia, delivery of oxygen at the wound site through oxygen releasing agents have been proven to be effective therapeutics. Several oxygen releasing nanoparticles such as Sodium Percarbonate (SPC), Calcium Peroxide (CPO), Hydrogen Peroxide, Magnesium Peroxide (MPO) have been investigated in wound healing application. However, the uncontrolled/burst release of these nanotherapeutic agents and its accompanied cytotoxicity pose a barrier in expediting the healing process. In this study, a Chitosan-Polyvinyl alcohol (CS-PVA) based hydrogel containing oxygen releasing nanoparticle, calcium peroxide (CPO) was constructed to provide a slow and sustained delivery of oxygen for at least 5 days. In-vitro cell culture studies with this material using fibroblast and endothelial cell line exhibited improved biocompatibility, cell viability and enhanced proliferation in comparison with the control group. Additionally, cell migration study using scratch assay method showed superior cell migration ability of our proposed materials. Furthermore, In vivo study using diabetic rat model showed accelerated wound closure rate compared to untreated control wounds.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2023.115156" rel="noreferrer" target="_blank">https://dx.doi.org/10.1016/j.biopha.2023.115156</a><br>Additional institutions affiliated with: Pak-Qatar Family Takaful Limited (PQFTL), Dow University of Health Sciences Qatar and Dow International Medical College – DUHSQ</p>2023-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.biopha.2023.115156https://figshare.com/articles/journal_contribution/A_calcium_peroxide_incorporated_oxygen_releasing_chitosan-PVA_patch_for_Diabetic_wound_healing/25287385CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252873852023-09-01T00:00:00Z |
| spellingShingle | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing Asad Ullah (4524541) Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Materials engineering Nanotechnology Diabetic wound healing Chronic hypoxia Oxygen releasing materials |
| status_str | publishedVersion |
| title | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing |
| title_full | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing |
| title_fullStr | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing |
| title_full_unstemmed | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing |
| title_short | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing |
| title_sort | A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Materials engineering Nanotechnology Diabetic wound healing Chronic hypoxia Oxygen releasing materials |