Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease
<h3>Objectives</h3><p dir="ltr">The aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease.</p><h3&g...
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2020
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| Summary: | <h3>Objectives</h3><p dir="ltr">The aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease.</p><h3>Methods</h3><p dir="ltr">This is a cross-sectional cohort study of twenty children with celiac disease and 20 healthy controls who underwent clinical and laboratory assessments and corneal confocal microscopy. Corneal nerve fiber density (no.mm<sup>2</sup>), corneal nerve branch density (no.mm<sup>2</sup>), corneal nerve fiber length (mm.mm<sup>2</sup>), corneal nerve fiber tortuosity and inferior whorl length (mm.mm<sup>2</sup>) were quantified manually.</p><h3>Results</h3><p dir="ltr">Corneal nerve fiber density (34.7±8.6 vs. 32.9±8.6; <i>P</i> = 0.5), corneal nerve branch density (47.2±24.5 vs. 47.3±20.0; <i>P</i> = 0.1) and corneal nerve fiber length (20.0±5.1 vs. 19.5±4.5; <i>P</i> = 0.8) did not differ between children with celiac disease and healthy controls. Corneal nerve fiber tortuosity (11.4±1.9 vs 13.5±3.0; <i>P</i> = 0.01) was significantly lower and inferior whorl length (20.0±5.5 vs 23.0±3.8; <i>P</i> = 0.06) showed a non-significant reduction in children with celiac disease compared to healthy controls. Inferior whorl length correlated significantly with corneal nerve fiber density (P = 0.005), corneal nerve branch density (P = 0.04), and corneal nerve fiber length (P = 0.002).</p><h3>Conclusion</h3><p dir="ltr">Corneal confocal microscopy demonstrates minimal evidence of neuropathy in children with celiac disease.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0238859" target="_blank">https://dx.doi.org/10.1371/journal.pone.0238859</a></p> |
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