Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease
<h3>Objectives</h3><p dir="ltr">The aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease.</p><h3&g...
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2020
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| _version_ | 1864513553633902592 |
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| author | Hoda Gad (6470522) |
| author2 | Saras Saraswathi (612858) Bara Al-Jarrah (9401910) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Adnan Khan (696190) Parul Singh (191877) Souhaila Al Khodor (89983) Mamoun Elawad (438979) Wesam Almasri (9401913) Hatim Abdelrahman (9401916) Khalid Hussain (110443) Mohamed A. Hendaus (9401919) Fatma Al-Mudahka (9401922) Khaled Abouhazima (9401925) Paraic McGrogan (388319) Rayaz A. Malik (7372649) Anthony K. Akobeng (7713470) |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_facet | Hoda Gad (6470522) Saras Saraswathi (612858) Bara Al-Jarrah (9401910) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Adnan Khan (696190) Parul Singh (191877) Souhaila Al Khodor (89983) Mamoun Elawad (438979) Wesam Almasri (9401913) Hatim Abdelrahman (9401916) Khalid Hussain (110443) Mohamed A. Hendaus (9401919) Fatma Al-Mudahka (9401922) Khaled Abouhazima (9401925) Paraic McGrogan (388319) Rayaz A. Malik (7372649) Anthony K. Akobeng (7713470) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hoda Gad (6470522) Saras Saraswathi (612858) Bara Al-Jarrah (9401910) Ioannis N. Petropoulos (8748726) Georgios Ponirakis (803076) Adnan Khan (696190) Parul Singh (191877) Souhaila Al Khodor (89983) Mamoun Elawad (438979) Wesam Almasri (9401913) Hatim Abdelrahman (9401916) Khalid Hussain (110443) Mohamed A. Hendaus (9401919) Fatma Al-Mudahka (9401922) Khaled Abouhazima (9401925) Paraic McGrogan (388319) Rayaz A. Malik (7372649) Anthony K. Akobeng (7713470) |
| dc.date.none.fl_str_mv | 2020-09-21T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0238859 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Corneal_confocal_microscopy_demonstrates_minimal_evidence_of_distal_neuropathy_in_children_with_celiac_disease/27959094 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Ophthalmology and optometry Cornea Nerve fibers Neuropathy Peripheral neuropathy Celiac disease Biopsy Platelets Confocal microscopy |
| dc.title.none.fl_str_mv | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objectives</h3><p dir="ltr">The aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease.</p><h3>Methods</h3><p dir="ltr">This is a cross-sectional cohort study of twenty children with celiac disease and 20 healthy controls who underwent clinical and laboratory assessments and corneal confocal microscopy. Corneal nerve fiber density (no.mm<sup>2</sup>), corneal nerve branch density (no.mm<sup>2</sup>), corneal nerve fiber length (mm.mm<sup>2</sup>), corneal nerve fiber tortuosity and inferior whorl length (mm.mm<sup>2</sup>) were quantified manually.</p><h3>Results</h3><p dir="ltr">Corneal nerve fiber density (34.7±8.6 vs. 32.9±8.6; <i>P</i> = 0.5), corneal nerve branch density (47.2±24.5 vs. 47.3±20.0; <i>P</i> = 0.1) and corneal nerve fiber length (20.0±5.1 vs. 19.5±4.5; <i>P</i> = 0.8) did not differ between children with celiac disease and healthy controls. Corneal nerve fiber tortuosity (11.4±1.9 vs 13.5±3.0; <i>P</i> = 0.01) was significantly lower and inferior whorl length (20.0±5.5 vs 23.0±3.8; <i>P</i> = 0.06) showed a non-significant reduction in children with celiac disease compared to healthy controls. Inferior whorl length correlated significantly with corneal nerve fiber density (P = 0.005), corneal nerve branch density (P = 0.04), and corneal nerve fiber length (P = 0.002).</p><h3>Conclusion</h3><p dir="ltr">Corneal confocal microscopy demonstrates minimal evidence of neuropathy in children with celiac disease.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0238859" target="_blank">https://dx.doi.org/10.1371/journal.pone.0238859</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_798bb13461fe96ff93f6840d2e070b80 |
| identifier_str_mv | 10.1371/journal.pone.0238859 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27959094 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac diseaseHoda Gad (6470522)Saras Saraswathi (612858)Bara Al-Jarrah (9401910)Ioannis N. Petropoulos (8748726)Georgios Ponirakis (803076)Adnan Khan (696190)Parul Singh (191877)Souhaila Al Khodor (89983)Mamoun Elawad (438979)Wesam Almasri (9401913)Hatim Abdelrahman (9401916)Khalid Hussain (110443)Mohamed A. Hendaus (9401919)Fatma Al-Mudahka (9401922)Khaled Abouhazima (9401925)Paraic McGrogan (388319)Rayaz A. Malik (7372649)Anthony K. Akobeng (7713470)Biomedical and clinical sciencesNeurosciencesOphthalmology and optometryCorneaNerve fibersNeuropathyPeripheral neuropathyCeliac diseaseBiopsyPlateletsConfocal microscopy<h3>Objectives</h3><p dir="ltr">The aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease.</p><h3>Methods</h3><p dir="ltr">This is a cross-sectional cohort study of twenty children with celiac disease and 20 healthy controls who underwent clinical and laboratory assessments and corneal confocal microscopy. Corneal nerve fiber density (no.mm<sup>2</sup>), corneal nerve branch density (no.mm<sup>2</sup>), corneal nerve fiber length (mm.mm<sup>2</sup>), corneal nerve fiber tortuosity and inferior whorl length (mm.mm<sup>2</sup>) were quantified manually.</p><h3>Results</h3><p dir="ltr">Corneal nerve fiber density (34.7±8.6 vs. 32.9±8.6; <i>P</i> = 0.5), corneal nerve branch density (47.2±24.5 vs. 47.3±20.0; <i>P</i> = 0.1) and corneal nerve fiber length (20.0±5.1 vs. 19.5±4.5; <i>P</i> = 0.8) did not differ between children with celiac disease and healthy controls. Corneal nerve fiber tortuosity (11.4±1.9 vs 13.5±3.0; <i>P</i> = 0.01) was significantly lower and inferior whorl length (20.0±5.5 vs 23.0±3.8; <i>P</i> = 0.06) showed a non-significant reduction in children with celiac disease compared to healthy controls. Inferior whorl length correlated significantly with corneal nerve fiber density (P = 0.005), corneal nerve branch density (P = 0.04), and corneal nerve fiber length (P = 0.002).</p><h3>Conclusion</h3><p dir="ltr">Corneal confocal microscopy demonstrates minimal evidence of neuropathy in children with celiac disease.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0238859" target="_blank">https://dx.doi.org/10.1371/journal.pone.0238859</a></p>2020-09-21T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1371/journal.pone.0238859https://figshare.com/articles/journal_contribution/Corneal_confocal_microscopy_demonstrates_minimal_evidence_of_distal_neuropathy_in_children_with_celiac_disease/27959094CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279590942020-09-21T03:00:00Z |
| spellingShingle | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease Hoda Gad (6470522) Biomedical and clinical sciences Neurosciences Ophthalmology and optometry Cornea Nerve fibers Neuropathy Peripheral neuropathy Celiac disease Biopsy Platelets Confocal microscopy |
| status_str | publishedVersion |
| title | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease |
| title_full | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease |
| title_fullStr | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease |
| title_full_unstemmed | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease |
| title_short | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease |
| title_sort | Corneal confocal microscopy demonstrates minimal evidence of distal neuropathy in children with celiac disease |
| topic | Biomedical and clinical sciences Neurosciences Ophthalmology and optometry Cornea Nerve fibers Neuropathy Peripheral neuropathy Celiac disease Biopsy Platelets Confocal microscopy |