Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes

<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant...

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Bibliographic Details
Main Author: Shadi Nejat (19457212) (author)
Other Authors: Kalhara R. Menikdiwela (18566698) (author), Aliyah Efotte (19457215) (author), Shane Scoggin (18566701) (author), Bolormaa Vandanmagsar (4330651) (author), Paul J. Thornalley (291723) (author), Mohammed Dehbi (309033) (author), Naima Moustaid-Moussa (66960) (author)
Published: 2023
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Clinical sciences
Medical biochemistry and metabolomics
obesity
type 2 diabetes
heat shock proteins
DNAJB3
adipose tissue
CRISPR-Cas9
inflammation
insulin resistance
glucose homeostasis
ER stress
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