Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes

<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Shadi Nejat (19457212) (author)
مؤلفون آخرون:	Kalhara R. Menikdiwela (18566698) (author), Aliyah Efotte (19457215) (author), Shane Scoggin (18566701) (author), Bolormaa Vandanmagsar (4330651) (author), Paul J. Thornalley (291723) (author), Mohammed Dehbi (309033) (author), Naima Moustaid-Moussa (66960) (author)
منشور في:	2023
الموضوعات:	Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics obesity type 2 diabetes heat shock proteins DNAJB3 adipose tissue CRISPR-Cas9 inflammation insulin resistance glucose homeostasis ER stress
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Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes

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