Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index
<p dir="ltr">Polycystic ovary syndrome (PCOS) is associated with metabolic consequences including obesity and insulin resistance that are related to the excess prevalence of type 2 diabetes, hypertension, and cardiovascular diseases in later life. It is reported that PCOS subjects sh...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2021
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| الموضوعات: | |
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| _version_ | 1864513516736610304 |
|---|---|
| author | Abu Saleh Md Moin (6189512) |
| author2 | Thozhukat Sathyapalan (704787) Alexandra E. Butler (6189536) Stephen L. Atkin (6684368) |
| author2_role | author author author |
| author_facet | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Alexandra E. Butler (6189536) Stephen L. Atkin (6684368) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Alexandra E. Butler (6189536) Stephen L. Atkin (6684368) |
| dc.date.none.fl_str_mv | 2021-06-02T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12967-021-02897-0 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Vitamin_D_association_with_coagulation_factors_in_polycystic_ovary_syndrome_is_dependent_upon_body_mass_index/25764345 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Reproductive medicine Polycystic ovary syndrome Vitamin D Obesity Fibrinogen Coagulation |
| dc.title.none.fl_str_mv | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Polycystic ovary syndrome (PCOS) is associated with metabolic consequences including obesity and insulin resistance that are related to the excess prevalence of type 2 diabetes, hypertension, and cardiovascular diseases in later life. It is reported that PCOS subjects show marked platelet dysfunction and decreased plasma fibrinolytic activity, resulting in a prothrombotic state. In addition, coagulation variables such as thrombin-activatable fibrinolysis inhibitor, plasminogen activator inhibitor-1 (PAI-1), D-dimer, Antithrombin and thrombomodulin have been reported to be elevated in PCOS compared to control subjects, and the functional coagulation tests including prothrombin time, thrombin time and fibrin degradation products may be predictive of PCOS. This suggests that PCOS women have a propensity to a hypercoagulable state; therefore, to determine whether this was the case in a cohort of PCOS women, and whether there was an association with vitamin D status, this study was undertaken.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-021-02897-0" target="_blank">https://dx.doi.org/10.1186/s12967-021-02897-0</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7b094c3f69ffbbe666c37d0bd682c29d |
| identifier_str_mv | 10.1186/s12967-021-02897-0 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25764345 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass indexAbu Saleh Md Moin (6189512)Thozhukat Sathyapalan (704787)Alexandra E. Butler (6189536)Stephen L. Atkin (6684368)Biomedical and clinical sciencesClinical sciencesReproductive medicinePolycystic ovary syndromeVitamin DObesityFibrinogenCoagulation<p dir="ltr">Polycystic ovary syndrome (PCOS) is associated with metabolic consequences including obesity and insulin resistance that are related to the excess prevalence of type 2 diabetes, hypertension, and cardiovascular diseases in later life. It is reported that PCOS subjects show marked platelet dysfunction and decreased plasma fibrinolytic activity, resulting in a prothrombotic state. In addition, coagulation variables such as thrombin-activatable fibrinolysis inhibitor, plasminogen activator inhibitor-1 (PAI-1), D-dimer, Antithrombin and thrombomodulin have been reported to be elevated in PCOS compared to control subjects, and the functional coagulation tests including prothrombin time, thrombin time and fibrin degradation products may be predictive of PCOS. This suggests that PCOS women have a propensity to a hypercoagulable state; therefore, to determine whether this was the case in a cohort of PCOS women, and whether there was an association with vitamin D status, this study was undertaken.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-021-02897-0" target="_blank">https://dx.doi.org/10.1186/s12967-021-02897-0</a></p>2021-06-02T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12967-021-02897-0https://figshare.com/articles/journal_contribution/Vitamin_D_association_with_coagulation_factors_in_polycystic_ovary_syndrome_is_dependent_upon_body_mass_index/25764345CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257643452021-06-02T03:00:00Z |
| spellingShingle | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index Abu Saleh Md Moin (6189512) Biomedical and clinical sciences Clinical sciences Reproductive medicine Polycystic ovary syndrome Vitamin D Obesity Fibrinogen Coagulation |
| status_str | publishedVersion |
| title | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index |
| title_full | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index |
| title_fullStr | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index |
| title_full_unstemmed | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index |
| title_short | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index |
| title_sort | Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index |
| topic | Biomedical and clinical sciences Clinical sciences Reproductive medicine Polycystic ovary syndrome Vitamin D Obesity Fibrinogen Coagulation |