The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin
<p dir="ltr"><i>Alternaria </i>species are mycotoxin-producing fungi known to infect fresh produce and to cause their spoilage. Humans get exposed to fungal secondary metabolites known as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C<sub>14&...
محفوظ في:
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| مؤلفون آخرون: | , |
| منشور في: |
2024
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| _version_ | 1864513543065305088 |
|---|---|
| author | Iman Saleh (14152878) |
| author2 | Randa Zeidan (14778388) Mohammed Abu-Dieyeh (14152164) |
| author2_role | author author |
| author_facet | Iman Saleh (14152878) Randa Zeidan (14778388) Mohammed Abu-Dieyeh (14152164) |
| author_role | author |
| dc.creator.none.fl_str_mv | Iman Saleh (14152878) Randa Zeidan (14778388) Mohammed Abu-Dieyeh (14152164) |
| dc.date.none.fl_str_mv | 2024-04-25T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00204-024-03743-0 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_characteristics_occurrence_and_toxicological_effects_of_alternariol_a_mycotoxin/29714933 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Public health Alternariol Mycotoxins Health risk assessment Mycotoxin occurance Genotoxicity |
| dc.title.none.fl_str_mv | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr"><i>Alternaria </i>species are mycotoxin-producing fungi known to infect fresh produce and to cause their spoilage. Humans get exposed to fungal secondary metabolites known as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C<sub>14</sub>H<sub>10</sub>O<sub>5</sub>) is an isocoumarins produced by different species of <i>Alternaria</i> including <i>Alternaria alternata</i>. AOH is often found in grain, fruits and fruits-based food products with high levels in legumes, nuts, and tomatoes. AOH was first discovered in 1953, and it is nowadays linked to esophagus cancer and endocrine disruption due to its similarity to estrogen. Although considered as an emerging mycotoxin with no regulated levels in food, AOH occurs in highly consumed dietary products and has been detected in various masked forms, which adds to its occurrence. Therefore, this comprehensive review was developed to give an overview on recent literature in the field of AOH. The current study summarizes published data on occurrence levels of AOH in different food products in the last ten years and evaluates those levels in comparison to recommended levels by the regulating entities. Such surveillance facilitates the work of health risk assessors and highlights commodities that are most in need of AOH levels regulation. In addition, the effects of AOH on cells and animal models were summarized in two tables; data include the last two-year literature studies. The review addresses also the main characteristics of AOH and the possible human exposure routes, the populations at risk, and the effect of anthropogenic activities on the widespread of the mycotoxin. The commonly used detection and control methods described in the latest literature are also discussed to guide future researchers to focus on mitigating mycotoxins contamination in the food industry. This review aims mainly to serve as a guideline on AOH for mycotoxin regulation developers and health risk assessors.</p><h2>Other Information</h2><p dir="ltr">Published in: Archives of Toxicology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00204-024-03743-0" target="_blank">https://dx.doi.org/10.1007/s00204-024-03743-0</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7bd902814e58c0348f9c2baad8453bc1 |
| identifier_str_mv | 10.1007/s00204-024-03743-0 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29714933 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxinIman Saleh (14152878)Randa Zeidan (14778388)Mohammed Abu-Dieyeh (14152164)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesHealth sciencesPublic healthAlternariolMycotoxinsHealth risk assessmentMycotoxin occuranceGenotoxicity<p dir="ltr"><i>Alternaria </i>species are mycotoxin-producing fungi known to infect fresh produce and to cause their spoilage. Humans get exposed to fungal secondary metabolites known as mycotoxin via the ingestion of contaminated food. Alternariol (AOH) (C<sub>14</sub>H<sub>10</sub>O<sub>5</sub>) is an isocoumarins produced by different species of <i>Alternaria</i> including <i>Alternaria alternata</i>. AOH is often found in grain, fruits and fruits-based food products with high levels in legumes, nuts, and tomatoes. AOH was first discovered in 1953, and it is nowadays linked to esophagus cancer and endocrine disruption due to its similarity to estrogen. Although considered as an emerging mycotoxin with no regulated levels in food, AOH occurs in highly consumed dietary products and has been detected in various masked forms, which adds to its occurrence. Therefore, this comprehensive review was developed to give an overview on recent literature in the field of AOH. The current study summarizes published data on occurrence levels of AOH in different food products in the last ten years and evaluates those levels in comparison to recommended levels by the regulating entities. Such surveillance facilitates the work of health risk assessors and highlights commodities that are most in need of AOH levels regulation. In addition, the effects of AOH on cells and animal models were summarized in two tables; data include the last two-year literature studies. The review addresses also the main characteristics of AOH and the possible human exposure routes, the populations at risk, and the effect of anthropogenic activities on the widespread of the mycotoxin. The commonly used detection and control methods described in the latest literature are also discussed to guide future researchers to focus on mitigating mycotoxins contamination in the food industry. This review aims mainly to serve as a guideline on AOH for mycotoxin regulation developers and health risk assessors.</p><h2>Other Information</h2><p dir="ltr">Published in: Archives of Toxicology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00204-024-03743-0" target="_blank">https://dx.doi.org/10.1007/s00204-024-03743-0</a></p>2024-04-25T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00204-024-03743-0https://figshare.com/articles/journal_contribution/The_characteristics_occurrence_and_toxicological_effects_of_alternariol_a_mycotoxin/29714933CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297149332024-04-25T09:00:00Z |
| spellingShingle | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin Iman Saleh (14152878) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Public health Alternariol Mycotoxins Health risk assessment Mycotoxin occurance Genotoxicity |
| status_str | publishedVersion |
| title | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin |
| title_full | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin |
| title_fullStr | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin |
| title_full_unstemmed | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin |
| title_short | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin |
| title_sort | The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Health sciences Public health Alternariol Mycotoxins Health risk assessment Mycotoxin occurance Genotoxicity |