Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer
<p>There is growing concern in the rise of colorectal cancer (CRC) cases globally, and with this rise is the presentation of drug resistance. Like other cancers, current treatment options are either invasive or manifest severe side effects. Thus, there is a move towards implementing safer trea...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513566540824576 |
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| author | Sourour Idoudi (14153457) |
| author2 | Takwa Bedhiafi (14153460) Yousef Mohammad Hijji (14153463) Nashiru Billa (4375261) |
| author2_role | author author author |
| author_facet | Sourour Idoudi (14153457) Takwa Bedhiafi (14153460) Yousef Mohammad Hijji (14153463) Nashiru Billa (4375261) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sourour Idoudi (14153457) Takwa Bedhiafi (14153460) Yousef Mohammad Hijji (14153463) Nashiru Billa (4375261) |
| dc.date.none.fl_str_mv | 2022-11-22T21:18:34Z |
| dc.identifier.none.fl_str_mv | 10.1208/s12249-022-02268-y |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Curcumin_and_Derivatives_in_Nanoformulations_with_Therapeutic_Potential_on_Colorectal_Cancer/21598554 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pharmacology and pharmaceutical sciences Drug Discovery Pharmaceutical Science Agronomy and Crop Science Ecology Aquatic Science General Medicine Ecology, Evolution, Behavior and Systematics |
| dc.title.none.fl_str_mv | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>There is growing concern in the rise of colorectal cancer (CRC) cases globally, and with this rise is the presentation of drug resistance. Like other cancers, current treatment options are either invasive or manifest severe side effects. Thus, there is a move towards implementing safer treatment options. Curcumin (CUR), extracted from Curcuma longa, has received significant attention by scientists as possible alternative to chemotherapeutic agents. It is safe and effective against CRC and nontoxic in moderate concentrations. Crucially, it specifically modulates apoptotic effects on CRC. However, the use of CUR is limited by its low solubility and poor bioavailability in aqueous media. These limitations are surmountable through novel approaches, such as nanoencapsulation of CUR, which masks the physicochemical properties of CUR, thus potentiating its anti-CRC effects. Furthermore, chemical derivatization of CUR is another approach that can be used to address the above constraints. This review spans published work in the last two decades, with key findings employing either of the two approaches, in addition to a combined approach in managing CRC. The combined approach affords the possibility of better treatment outcomes but not widely investigated nor yet clinically implemented.</p> <p>Graphical Abstract</p><h2>Other Information</h2> <p> Published in: AAPS PharmSciTech<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1208/s12249-022-02268-y" target="_blank">http://dx.doi.org/10.1208/s12249-022-02268-y</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7bfb5118646bfafef7a147bba9170a55 |
| identifier_str_mv | 10.1208/s12249-022-02268-y |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598554 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal CancerSourour Idoudi (14153457)Takwa Bedhiafi (14153460)Yousef Mohammad Hijji (14153463)Nashiru Billa (4375261)Pharmacology and pharmaceutical sciencesDrug DiscoveryPharmaceutical ScienceAgronomy and Crop ScienceEcologyAquatic ScienceGeneral MedicineEcology, Evolution, Behavior and Systematics<p>There is growing concern in the rise of colorectal cancer (CRC) cases globally, and with this rise is the presentation of drug resistance. Like other cancers, current treatment options are either invasive or manifest severe side effects. Thus, there is a move towards implementing safer treatment options. Curcumin (CUR), extracted from Curcuma longa, has received significant attention by scientists as possible alternative to chemotherapeutic agents. It is safe and effective against CRC and nontoxic in moderate concentrations. Crucially, it specifically modulates apoptotic effects on CRC. However, the use of CUR is limited by its low solubility and poor bioavailability in aqueous media. These limitations are surmountable through novel approaches, such as nanoencapsulation of CUR, which masks the physicochemical properties of CUR, thus potentiating its anti-CRC effects. Furthermore, chemical derivatization of CUR is another approach that can be used to address the above constraints. This review spans published work in the last two decades, with key findings employing either of the two approaches, in addition to a combined approach in managing CRC. The combined approach affords the possibility of better treatment outcomes but not widely investigated nor yet clinically implemented.</p> <p>Graphical Abstract</p><h2>Other Information</h2> <p> Published in: AAPS PharmSciTech<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1208/s12249-022-02268-y" target="_blank">http://dx.doi.org/10.1208/s12249-022-02268-y</a></p>2022-11-22T21:18:34ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1208/s12249-022-02268-yhttps://figshare.com/articles/journal_contribution/Curcumin_and_Derivatives_in_Nanoformulations_with_Therapeutic_Potential_on_Colorectal_Cancer/21598554CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215985542022-11-22T21:18:34Z |
| spellingShingle | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer Sourour Idoudi (14153457) Pharmacology and pharmaceutical sciences Drug Discovery Pharmaceutical Science Agronomy and Crop Science Ecology Aquatic Science General Medicine Ecology, Evolution, Behavior and Systematics |
| status_str | publishedVersion |
| title | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer |
| title_full | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer |
| title_fullStr | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer |
| title_full_unstemmed | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer |
| title_short | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer |
| title_sort | Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer |
| topic | Pharmacology and pharmaceutical sciences Drug Discovery Pharmaceutical Science Agronomy and Crop Science Ecology Aquatic Science General Medicine Ecology, Evolution, Behavior and Systematics |