COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case
<p dir="ltr">Hiccups manifest as involuntary and repetitive diaphragm contractions, often involving the intercostal muscles. However, the precise underlying mechanism remains incompletely understood but typically benign. During the COVID-19 pandemic, the predominant clinical presenta...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2025
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| _version_ | 1864513550048821248 |
|---|---|
| author | Mohammed Aloqaily (20966390) |
| author2 | Alaa Tarazi (14145249) Abdullah Ammar (21098061) Ibrahim Alfarrajin (21098064) Ra'ed Ababneh (20905286) Wafi A. Aloqaily (21098066) Yousef Alasaad (21098081) |
| author2_role | author author author author author author |
| author_facet | Mohammed Aloqaily (20966390) Alaa Tarazi (14145249) Abdullah Ammar (21098061) Ibrahim Alfarrajin (21098064) Ra'ed Ababneh (20905286) Wafi A. Aloqaily (21098066) Yousef Alasaad (21098081) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohammed Aloqaily (20966390) Alaa Tarazi (14145249) Abdullah Ammar (21098061) Ibrahim Alfarrajin (21098064) Ra'ed Ababneh (20905286) Wafi A. Aloqaily (21098066) Yousef Alasaad (21098081) |
| dc.date.none.fl_str_mv | 2025-02-07T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.7759/cureus.78701 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/COVID-19_Presenting_With_Intractable_Hiccups_A_Literature_Review_and_a_New_Case/28803920 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 critical care hiccups persistent hiccups pulmonology |
| dc.title.none.fl_str_mv | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Hiccups manifest as involuntary and repetitive diaphragm contractions, often involving the intercostal muscles. However, the precise underlying mechanism remains incompletely understood but typically benign. During the COVID-19 pandemic, the predominant clinical presentation featured fever, cough, and dyspnea. However, multiple atypical presentations are increasingly recognized as manifestations of COVID-19, including refractory hiccups. This article aims to examine the shared characteristics, distinctions, notable correlations, and prognosis among COVID-19 patients presenting with intractable hiccups. Additionally, we present a 79-year-old male with a history of Parkinson’s disease, hypertension, and diabetes who presented with refractory hiccups, cough, and a runny nose. Laboratory analysis revealed elevated inflammatory markers and a positive COVID-19 test. The patient responded well to medical management, and the hiccups were resolved.</p><p dir="ltr">Notably, the association between persistent hiccups and COVID-19 infection is increasingly recognized, predominantly affecting older males with comorbidities and can be the sole complaint. Furthermore, we analyzed 29 cases of COVID-19 with persistent hiccups in the English literature. The mean duration of symptoms was 3.9 days with the majority of these cases being males (96.55%) and an average age of affected individuals of 58.28 years. Cough was the most frequently associated symptom (31.03%), while an equal proportion of patients (31.03%) reported intractable hiccups as their sole complaint. Additionally, common findings included elevated inflammatory markers, electrolyte imbalances, and infiltrates on imaging. Most of the patients demonstrated substantial improvement through symptomatic and medical management; however, mortality was documented in two cases, which highlights the potential for this seemingly benign manifestation to mislead and necessitate thorough evaluation upon presentation.</p><h2>Other Information</h2><p dir="ltr">Published in: Cureus<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://doi.org/10.7759/cureus.78701" target="_blank">https://doi.org/10.7759/cureus.78701</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7c83e85a8a4a43a249623d83ab396923 |
| identifier_str_mv | 10.7759/cureus.78701 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28803920 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New CaseMohammed Aloqaily (20966390)Alaa Tarazi (14145249)Abdullah Ammar (21098061)Ibrahim Alfarrajin (21098064)Ra'ed Ababneh (20905286)Wafi A. Aloqaily (21098066)Yousef Alasaad (21098081)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesCOVID-19critical carehiccupspersistent hiccupspulmonology<p dir="ltr">Hiccups manifest as involuntary and repetitive diaphragm contractions, often involving the intercostal muscles. However, the precise underlying mechanism remains incompletely understood but typically benign. During the COVID-19 pandemic, the predominant clinical presentation featured fever, cough, and dyspnea. However, multiple atypical presentations are increasingly recognized as manifestations of COVID-19, including refractory hiccups. This article aims to examine the shared characteristics, distinctions, notable correlations, and prognosis among COVID-19 patients presenting with intractable hiccups. Additionally, we present a 79-year-old male with a history of Parkinson’s disease, hypertension, and diabetes who presented with refractory hiccups, cough, and a runny nose. Laboratory analysis revealed elevated inflammatory markers and a positive COVID-19 test. The patient responded well to medical management, and the hiccups were resolved.</p><p dir="ltr">Notably, the association between persistent hiccups and COVID-19 infection is increasingly recognized, predominantly affecting older males with comorbidities and can be the sole complaint. Furthermore, we analyzed 29 cases of COVID-19 with persistent hiccups in the English literature. The mean duration of symptoms was 3.9 days with the majority of these cases being males (96.55%) and an average age of affected individuals of 58.28 years. Cough was the most frequently associated symptom (31.03%), while an equal proportion of patients (31.03%) reported intractable hiccups as their sole complaint. Additionally, common findings included elevated inflammatory markers, electrolyte imbalances, and infiltrates on imaging. Most of the patients demonstrated substantial improvement through symptomatic and medical management; however, mortality was documented in two cases, which highlights the potential for this seemingly benign manifestation to mislead and necessitate thorough evaluation upon presentation.</p><h2>Other Information</h2><p dir="ltr">Published in: Cureus<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://doi.org/10.7759/cureus.78701" target="_blank">https://doi.org/10.7759/cureus.78701</a></p>2025-02-07T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.7759/cureus.78701https://figshare.com/articles/journal_contribution/COVID-19_Presenting_With_Intractable_Hiccups_A_Literature_Review_and_a_New_Case/28803920CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/288039202025-02-07T00:00:00Z |
| spellingShingle | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case Mohammed Aloqaily (20966390) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 critical care hiccups persistent hiccups pulmonology |
| status_str | publishedVersion |
| title | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case |
| title_full | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case |
| title_fullStr | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case |
| title_full_unstemmed | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case |
| title_short | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case |
| title_sort | COVID-19 Presenting With Intractable Hiccups: A Literature Review and a New Case |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 critical care hiccups persistent hiccups pulmonology |