Estrogens and the risk of breast cancer: A narrative review of literature
<p>In female mammals, the development and regulation of the reproductive system and non-reproductive system are significantly influenced by estrogens (oestrogens). In addition, lipid metabolism is another physiological role of estrogens. Estrogens act through different types of receptors to in...
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2023
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| _version_ | 1864513526412869632 |
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| author | Khayry Al-Shami (17863865) |
| author2 | Sajeda Awadi (17863862) Almu'atasim Khamees (11875640) Ahmad Malek Alsheikh (17863874) Sumaiya Al-Sharif (18024355) Raneem Ala’ Bereshy (18024358) Sharaf F. Al-Eitan (17863871) Sajedah H. Banikhaled (18024361) Ahmad R. Al-Qudimat (17337808) Raed M. Al-Zoubi (2037490) Mazhar Salim Al Zoubi (18024364) |
| author2_role | author author author author author author author author author author |
| author_facet | Khayry Al-Shami (17863865) Sajeda Awadi (17863862) Almu'atasim Khamees (11875640) Ahmad Malek Alsheikh (17863874) Sumaiya Al-Sharif (18024355) Raneem Ala’ Bereshy (18024358) Sharaf F. Al-Eitan (17863871) Sajedah H. Banikhaled (18024361) Ahmad R. Al-Qudimat (17337808) Raed M. Al-Zoubi (2037490) Mazhar Salim Al Zoubi (18024364) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khayry Al-Shami (17863865) Sajeda Awadi (17863862) Almu'atasim Khamees (11875640) Ahmad Malek Alsheikh (17863874) Sumaiya Al-Sharif (18024355) Raneem Ala’ Bereshy (18024358) Sharaf F. Al-Eitan (17863871) Sajedah H. Banikhaled (18024361) Ahmad R. Al-Qudimat (17337808) Raed M. Al-Zoubi (2037490) Mazhar Salim Al Zoubi (18024364) |
| dc.date.none.fl_str_mv | 2023-09-16T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.heliyon.2023.e20224 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Estrogens_and_the_risk_of_breast_cancer_A_narrative_review_of_literature/25287466 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Estrogen Oestrogen Risk Breast cancer ER |
| dc.title.none.fl_str_mv | Estrogens and the risk of breast cancer: A narrative review of literature |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>In female mammals, the development and regulation of the reproductive system and non-reproductive system are significantly influenced by estrogens (oestrogens). In addition, lipid metabolism is another physiological role of estrogens. Estrogens act through different types of receptors to introduce signals to the target cell by affecting many estrogen response elements. Breast cancer is considered mostly a hormone-dependent disease. Approximately 70% of breast cancers express progesterone receptors and/or estrogen receptors, and they are a good marker for cancer prognosis. This review will discuss estrogen metabolism and the interaction of estrogen metabolites with breast cancer. The carcinogenic role of estrogen is discussed in light of both conventional and atypical cancers susceptible to hormones, such as prostate, endometrial, and lung cancer, as we examine how estrogen contributes to the formation and activation of breast cancer. In addition, this review will discuss other factors that can be associated with estrogen-driven breast cancer.</p><h2>Other Information</h2> <p> Published in: Heliyon<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.heliyon.2023.e20224" target="_blank">https://dx.doi.org/10.1016/j.heliyon.2023.e20224</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7ca791eb1547a4f42f7f51e2465ca724 |
| identifier_str_mv | 10.1016/j.heliyon.2023.e20224 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25287466 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Estrogens and the risk of breast cancer: A narrative review of literatureKhayry Al-Shami (17863865)Sajeda Awadi (17863862)Almu'atasim Khamees (11875640)Ahmad Malek Alsheikh (17863874)Sumaiya Al-Sharif (18024355)Raneem Ala’ Bereshy (18024358)Sharaf F. Al-Eitan (17863871)Sajedah H. Banikhaled (18024361)Ahmad R. Al-Qudimat (17337808)Raed M. Al-Zoubi (2037490)Mazhar Salim Al Zoubi (18024364)Biomedical and clinical sciencesOncology and carcinogenesisEstrogenOestrogenRiskBreast cancerER<p>In female mammals, the development and regulation of the reproductive system and non-reproductive system are significantly influenced by estrogens (oestrogens). In addition, lipid metabolism is another physiological role of estrogens. Estrogens act through different types of receptors to introduce signals to the target cell by affecting many estrogen response elements. Breast cancer is considered mostly a hormone-dependent disease. Approximately 70% of breast cancers express progesterone receptors and/or estrogen receptors, and they are a good marker for cancer prognosis. This review will discuss estrogen metabolism and the interaction of estrogen metabolites with breast cancer. The carcinogenic role of estrogen is discussed in light of both conventional and atypical cancers susceptible to hormones, such as prostate, endometrial, and lung cancer, as we examine how estrogen contributes to the formation and activation of breast cancer. In addition, this review will discuss other factors that can be associated with estrogen-driven breast cancer.</p><h2>Other Information</h2> <p> Published in: Heliyon<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.heliyon.2023.e20224" target="_blank">https://dx.doi.org/10.1016/j.heliyon.2023.e20224</a></p>2023-09-16T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.heliyon.2023.e20224https://figshare.com/articles/journal_contribution/Estrogens_and_the_risk_of_breast_cancer_A_narrative_review_of_literature/25287466CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252874662023-09-16T03:00:00Z |
| spellingShingle | Estrogens and the risk of breast cancer: A narrative review of literature Khayry Al-Shami (17863865) Biomedical and clinical sciences Oncology and carcinogenesis Estrogen Oestrogen Risk Breast cancer ER |
| status_str | publishedVersion |
| title | Estrogens and the risk of breast cancer: A narrative review of literature |
| title_full | Estrogens and the risk of breast cancer: A narrative review of literature |
| title_fullStr | Estrogens and the risk of breast cancer: A narrative review of literature |
| title_full_unstemmed | Estrogens and the risk of breast cancer: A narrative review of literature |
| title_short | Estrogens and the risk of breast cancer: A narrative review of literature |
| title_sort | Estrogens and the risk of breast cancer: A narrative review of literature |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Estrogen Oestrogen Risk Breast cancer ER |