Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF
<h3>Background</h3><p dir="ltr">Chronic psychosocial stress impairs memory function and leads to a depression-like phenotype induced by a persistent status of oxidative stress. Hypericum perforatum L. (St. John’s wort) is widely used to relieve symptoms of anxiety and dep...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2020
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513553990418432 |
|---|---|
| author | Karem H Alzoubi (13026873) |
| author2 | Laila Abdel-Hafiz (20362770) Omar F Khabour (20362734) Tamam El-Elimat (694398) Mohammad A Alzubi (20362773) Feras Q Alali (20362776) |
| author2_role | author author author author author |
| author_facet | Karem H Alzoubi (13026873) Laila Abdel-Hafiz (20362770) Omar F Khabour (20362734) Tamam El-Elimat (694398) Mohammad A Alzubi (20362773) Feras Q Alali (20362776) |
| author_role | author |
| dc.creator.none.fl_str_mv | Karem H Alzoubi (13026873) Laila Abdel-Hafiz (20362770) Omar F Khabour (20362734) Tamam El-Elimat (694398) Mohammad A Alzubi (20362773) Feras Q Alali (20362776) |
| dc.date.none.fl_str_mv | 2020-12-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/dddt.s278153 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Evaluation_of_the_Effect_of_i_Hypericum_triquetrifolium_i_Turra_on_Memory_Impairment_Induced_by_Chronic_Psychosocial_Stress_in_Rats_Role_of_BDNF/27935301 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Hypericum triquetrifolium methanolic extract stress learning memory hippocampus BDNF |
| dc.title.none.fl_str_mv | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Chronic psychosocial stress impairs memory function and leads to a depression-like phenotype induced by a persistent status of oxidative stress. Hypericum perforatum L. (St. John’s wort) is widely used to relieve symptoms of anxiety and depres sion; however, its long-term use is associated with adverse effects. Hypericum triquetrifolium Turra is closely related to H. perforatum. Both plants belong to Hypericaceae family and share many biologically active compounds. Previous work by our group showed that methanolic extracts of H. triquetrifolium have potent antioxidant activity as well as high hypericin content, a component that proved to have stress-relieving and antidepressant effects by other studies. Therefore, we hypothesized that H. triquetrifolium would reduce stress-induced cognitive impairment in a rat model of chronic stress. </p><h3>Objective</h3><p dir="ltr">To determine whether chronic treatment with H. triquetrifolium protects against stress-associated memory deficits and to investigate a possible mechanism. </p><h3>Methods</h3><p dir="ltr">The radial arm water maze (RAWM) was used to test learning and memory in rats exposed to daily stress using the resident–intruder paradigm. Stressed and unstressed rats received chronic H. triquetrifolium or vehicle. We also measured levels of brain-derived neurotrophic factor (BDNF) in the hippocampus, cortex and cerebellum. </p><h3>Results</h3><p dir="ltr">Neither chronic stress nor chronic H. triquetrifolium administration affected per formance during acquisition. However, memory tests in the RAWM showed that chronic stress impaired different post-encoding memory stages. H. triquetrifolium prevented this impairment. Furthermore, hippocampal BDNF levels were markedly lower in stressed animals than in unstressed animals, and chronic administration of H triquetrifolium chronic administration protected against this reduction. No significant difference was observed in the effects of chronic stress and/or H. triquetrifolium treatment on BDNF levels in the cerebel lum and cortex. </p><h3>Conclusion</h3><p dir="ltr">H. triquetrifolium extract can oppose stress-associated hippocampus-dependent memory deficits in a mechanism that may involve BDNF in the hippocampus.</p><h2>Other Information</h2><p dir="ltr">Published in: Drug Design, Development and Therapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/dddt.s278153" target="_blank">https://dx.doi.org/10.2147/dddt.s278153</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7d3b55a734178cd23f2c7d57630bed4f |
| identifier_str_mv | 10.2147/dddt.s278153 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27935301 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNFKarem H Alzoubi (13026873)Laila Abdel-Hafiz (20362770)Omar F Khabour (20362734)Tamam El-Elimat (694398)Mohammad A Alzubi (20362773)Feras Q Alali (20362776)Biomedical and clinical sciencesNeurosciencesPharmacology and pharmaceutical sciencesHypericum triquetrifoliummethanolic extractstresslearningmemoryhippocampusBDNF<h3>Background</h3><p dir="ltr">Chronic psychosocial stress impairs memory function and leads to a depression-like phenotype induced by a persistent status of oxidative stress. Hypericum perforatum L. (St. John’s wort) is widely used to relieve symptoms of anxiety and depres sion; however, its long-term use is associated with adverse effects. Hypericum triquetrifolium Turra is closely related to H. perforatum. Both plants belong to Hypericaceae family and share many biologically active compounds. Previous work by our group showed that methanolic extracts of H. triquetrifolium have potent antioxidant activity as well as high hypericin content, a component that proved to have stress-relieving and antidepressant effects by other studies. Therefore, we hypothesized that H. triquetrifolium would reduce stress-induced cognitive impairment in a rat model of chronic stress. </p><h3>Objective</h3><p dir="ltr">To determine whether chronic treatment with H. triquetrifolium protects against stress-associated memory deficits and to investigate a possible mechanism. </p><h3>Methods</h3><p dir="ltr">The radial arm water maze (RAWM) was used to test learning and memory in rats exposed to daily stress using the resident–intruder paradigm. Stressed and unstressed rats received chronic H. triquetrifolium or vehicle. We also measured levels of brain-derived neurotrophic factor (BDNF) in the hippocampus, cortex and cerebellum. </p><h3>Results</h3><p dir="ltr">Neither chronic stress nor chronic H. triquetrifolium administration affected per formance during acquisition. However, memory tests in the RAWM showed that chronic stress impaired different post-encoding memory stages. H. triquetrifolium prevented this impairment. Furthermore, hippocampal BDNF levels were markedly lower in stressed animals than in unstressed animals, and chronic administration of H triquetrifolium chronic administration protected against this reduction. No significant difference was observed in the effects of chronic stress and/or H. triquetrifolium treatment on BDNF levels in the cerebel lum and cortex. </p><h3>Conclusion</h3><p dir="ltr">H. triquetrifolium extract can oppose stress-associated hippocampus-dependent memory deficits in a mechanism that may involve BDNF in the hippocampus.</p><h2>Other Information</h2><p dir="ltr">Published in: Drug Design, Development and Therapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/dddt.s278153" target="_blank">https://dx.doi.org/10.2147/dddt.s278153</a></p>2020-12-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/dddt.s278153https://figshare.com/articles/journal_contribution/Evaluation_of_the_Effect_of_i_Hypericum_triquetrifolium_i_Turra_on_Memory_Impairment_Induced_by_Chronic_Psychosocial_Stress_in_Rats_Role_of_BDNF/27935301CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279353012020-12-01T00:00:00Z |
| spellingShingle | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF Karem H Alzoubi (13026873) Biomedical and clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Hypericum triquetrifolium methanolic extract stress learning memory hippocampus BDNF |
| status_str | publishedVersion |
| title | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF |
| title_full | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF |
| title_fullStr | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF |
| title_full_unstemmed | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF |
| title_short | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF |
| title_sort | Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF |
| topic | Biomedical and clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Hypericum triquetrifolium methanolic extract stress learning memory hippocampus BDNF |