Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report
<p dir="ltr">Hyperthyroidism, marked by excess thyroid hormones (T4 and T3), presents with symptoms like palpitations, heat intolerance, anxiety, and weight loss despite a normal or increased appetite. Diagnosis involves low serum TSH levels and elevated free T4 and/or T3. Rarely, hy...
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2025
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| _version_ | 1864513537969225728 |
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| author | Elias Battikh (13804647) |
| author2 | Sherif Mostafa (13548916) Hadeel Alfar (21383702) Koutaibah Obaid (21768293) Ashraf I. Ahmed (22045163) Bisher Sawaf (4972819) Dabia Al‐Mohanadi (22391668) |
| author2_role | author author author author author author |
| author_facet | Elias Battikh (13804647) Sherif Mostafa (13548916) Hadeel Alfar (21383702) Koutaibah Obaid (21768293) Ashraf I. Ahmed (22045163) Bisher Sawaf (4972819) Dabia Al‐Mohanadi (22391668) |
| author_role | author |
| dc.creator.none.fl_str_mv | Elias Battikh (13804647) Sherif Mostafa (13548916) Hadeel Alfar (21383702) Koutaibah Obaid (21768293) Ashraf I. Ahmed (22045163) Bisher Sawaf (4972819) Dabia Al‐Mohanadi (22391668) |
| dc.date.none.fl_str_mv | 2025-02-19T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/ccr3.9698 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Hyperthyroidism_Induced_Nondiabetic_Ketoacidosis_A_Rare_Case_Report/30305737 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics hyperthyroid nondiabetic ketoacidosis (NDKA) thyroid stimulating hormone thyrotoxicosis |
| dc.title.none.fl_str_mv | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Hyperthyroidism, marked by excess thyroid hormones (T4 and T3), presents with symptoms like palpitations, heat intolerance, anxiety, and weight loss despite a normal or increased appetite. Diagnosis involves low serum TSH levels and elevated free T4 and/or T3. Rarely, hyperthyroidism can lead to nondiabetic ketoacidosis (NDKA). This report describes a 40‐year‐old woman with palpitations, chest discomfort, heat intolerance, insomnia, and significant weight loss. Laboratory tests showed severely suppressed TSH, elevated free T4 and T3, and high anion gap metabolic acidosis with elevated ketone levels. She was diagnosed with hyperthyroidism‐induced NDKA. Hyperthyroidism can promote lipolysis and ketogenesis, potentially leading to NDKA. Though uncommon, it is essential for clinicians to consider hyperthyroidism in NDKA cases when common causes are excluded. Our patient's symptoms significantly improved with propranolol and carbimazole treatment. This case emphasizes the importance of recognizing hyperthyroidism as a potential cause of NDKA. Appropriate diagnosis and treatment with antithyroid medications can lead to complete symptom resolution and normalization of biochemical markers.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.9698" target="_blank">https://dx.doi.org/10.1002/ccr3.9698</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_7d83e95eb1324eca7dd556b5d2e8f4ed |
| identifier_str_mv | 10.1002/ccr3.9698 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30305737 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case ReportElias Battikh (13804647)Sherif Mostafa (13548916)Hadeel Alfar (21383702)Koutaibah Obaid (21768293)Ashraf I. Ahmed (22045163)Bisher Sawaf (4972819)Dabia Al‐Mohanadi (22391668)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicshyperthyroidnondiabetic ketoacidosis (NDKA)thyroid stimulating hormonethyrotoxicosis<p dir="ltr">Hyperthyroidism, marked by excess thyroid hormones (T4 and T3), presents with symptoms like palpitations, heat intolerance, anxiety, and weight loss despite a normal or increased appetite. Diagnosis involves low serum TSH levels and elevated free T4 and/or T3. Rarely, hyperthyroidism can lead to nondiabetic ketoacidosis (NDKA). This report describes a 40‐year‐old woman with palpitations, chest discomfort, heat intolerance, insomnia, and significant weight loss. Laboratory tests showed severely suppressed TSH, elevated free T4 and T3, and high anion gap metabolic acidosis with elevated ketone levels. She was diagnosed with hyperthyroidism‐induced NDKA. Hyperthyroidism can promote lipolysis and ketogenesis, potentially leading to NDKA. Though uncommon, it is essential for clinicians to consider hyperthyroidism in NDKA cases when common causes are excluded. Our patient's symptoms significantly improved with propranolol and carbimazole treatment. This case emphasizes the importance of recognizing hyperthyroidism as a potential cause of NDKA. Appropriate diagnosis and treatment with antithyroid medications can lead to complete symptom resolution and normalization of biochemical markers.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.9698" target="_blank">https://dx.doi.org/10.1002/ccr3.9698</a></p>2025-02-19T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/ccr3.9698https://figshare.com/articles/journal_contribution/Hyperthyroidism_Induced_Nondiabetic_Ketoacidosis_A_Rare_Case_Report/30305737CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/303057372025-02-19T09:00:00Z |
| spellingShingle | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report Elias Battikh (13804647) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics hyperthyroid nondiabetic ketoacidosis (NDKA) thyroid stimulating hormone thyrotoxicosis |
| status_str | publishedVersion |
| title | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report |
| title_full | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report |
| title_fullStr | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report |
| title_full_unstemmed | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report |
| title_short | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report |
| title_sort | Hyperthyroidism‐Induced Nondiabetic Ketoacidosis: A Rare Case Report |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics hyperthyroid nondiabetic ketoacidosis (NDKA) thyroid stimulating hormone thyrotoxicosis |