Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization

<div><p>In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual loss of cholesterol in the synapt...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Adrián Martín‐Segura (18615133) (author)
مؤلفون آخرون: Tariq Ahmed (5768081) (author), Álvaro Casadomé‐Perales (18615136) (author), Irene Palomares‐Perez (18615139) (author), Ernest Palomer (349259) (author), Axelle Kerstens (6183554) (author), Sebastian Munck (355816) (author), Detlef Balschun (8096618) (author), Carlos G. Dotti (6872990) (author)
منشور في: 2019
الموضوعات:
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