Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model
<h3>Introduction</h3><p dir="ltr">Diabetic neuropathy is a common consequence of diabetes. Hyperalgesia is one of the main symptoms of diabetic neuropathy. In response to noxious stimuli, streptozotocin (STZ)-induced diabetic rats show exaggerated hyperalgesic behavior, w...
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2020
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| author | Mohamed M Abdel-Daim (20362725) |
| author2 | Mohamed Shaaban Ali (20362728) Fedekar F. Madkour (11535386) Hamed Elgendy (11570543) |
| author2_role | author author author |
| author_facet | Mohamed M Abdel-Daim (20362725) Mohamed Shaaban Ali (20362728) Fedekar F. Madkour (11535386) Hamed Elgendy (11570543) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohamed M Abdel-Daim (20362725) Mohamed Shaaban Ali (20362728) Fedekar F. Madkour (11535386) Hamed Elgendy (11570543) |
| dc.date.none.fl_str_mv | 2020-09-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/jpr.s267347 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Oral_Spirulina_Platensis_Attenuates_Hyperglycemia_and_Exhibits_Antinociceptive_Effect_in_Streptozotocin-Induced_Diabetic_Neuropathy_Rat_Model/27935265 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences antinociceptive Spirulina platensis diabetes neuropathy rat |
| dc.title.none.fl_str_mv | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Diabetic neuropathy is a common consequence of diabetes. Hyperalgesia is one of the main symptoms of diabetic neuropathy. In response to noxious stimuli, streptozotocin (STZ)-induced diabetic rats show exaggerated hyperalgesic behavior, while Spirulina platensis has anti-inflammatory, antioxidant, and insulin-like effects. To assess the antinociceptive effect of oral Spirulina platensis (SP) powder on formalin-induced nociceptive responses in STZ-induced diabetic rats.</p><h3>Methods</h3><p dir="ltr">Sixty mature male albino rats were randomly allocated into six equal groups (10 in each group). Group 1 (control non-diabetic group) received 0.9% saline; group 2 was given oral pure SP powder-treated as a non-diabetic control group, group 3 was sodium salicylate-treated rats and used as a positive non-diabetic control group, group 4 managed as vehicle-treated diabetic rats, group 5 considered as SP-treated-diabetic group, and sodium salicylate-treated-diabetic rats used as a diabetic positive control group (group 6). STZ-diabetic rats were orally given SP in a dose of 500 mg kg/day for 1 month. The formalin test was implemented in two phases: the early phase in the first 10-min post-formalin injection, and the late phase was considered in the 15– 60 min post-formalin injection time interval.</p><h3>Results</h3><p dir="ltr">Pain scores were increased in the diabetic groups during both phases of the experiment. Blood glucose was significantly reduced in diabetic rats that received oral SP, P < 0.01. Besides, SP-treated rats had lower pain scores during both phases of the experiment than untreated diabetic ones. However, in the sodium salicylate group, the pain score was reduced only during the second phase. An exaggerated nociceptive response occurred in diabetic rats after the formalin test. A significant antinociceptive effect appeared in SP-treated control and diabetic rats.</p><h3>Discussion</h3><p dir="ltr">The findings suggest that oral <i>Spirulina platensis</i> could have a potential therapeutic role for managing induced painful diabetic neuropathy in rats.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Pain Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/jpr.s267347" target="_blank">https://dx.doi.org/10.2147/jpr.s267347</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_80349bfb2731d55c18fb6d24eb818ccf |
| identifier_str_mv | 10.2147/jpr.s267347 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27935265 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat ModelMohamed M Abdel-Daim (20362725)Mohamed Shaaban Ali (20362728)Fedekar F. Madkour (11535386)Hamed Elgendy (11570543)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesantinociceptiveSpirulina platensisdiabetesneuropathyrat<h3>Introduction</h3><p dir="ltr">Diabetic neuropathy is a common consequence of diabetes. Hyperalgesia is one of the main symptoms of diabetic neuropathy. In response to noxious stimuli, streptozotocin (STZ)-induced diabetic rats show exaggerated hyperalgesic behavior, while Spirulina platensis has anti-inflammatory, antioxidant, and insulin-like effects. To assess the antinociceptive effect of oral Spirulina platensis (SP) powder on formalin-induced nociceptive responses in STZ-induced diabetic rats.</p><h3>Methods</h3><p dir="ltr">Sixty mature male albino rats were randomly allocated into six equal groups (10 in each group). Group 1 (control non-diabetic group) received 0.9% saline; group 2 was given oral pure SP powder-treated as a non-diabetic control group, group 3 was sodium salicylate-treated rats and used as a positive non-diabetic control group, group 4 managed as vehicle-treated diabetic rats, group 5 considered as SP-treated-diabetic group, and sodium salicylate-treated-diabetic rats used as a diabetic positive control group (group 6). STZ-diabetic rats were orally given SP in a dose of 500 mg kg/day for 1 month. The formalin test was implemented in two phases: the early phase in the first 10-min post-formalin injection, and the late phase was considered in the 15– 60 min post-formalin injection time interval.</p><h3>Results</h3><p dir="ltr">Pain scores were increased in the diabetic groups during both phases of the experiment. Blood glucose was significantly reduced in diabetic rats that received oral SP, P < 0.01. Besides, SP-treated rats had lower pain scores during both phases of the experiment than untreated diabetic ones. However, in the sodium salicylate group, the pain score was reduced only during the second phase. An exaggerated nociceptive response occurred in diabetic rats after the formalin test. A significant antinociceptive effect appeared in SP-treated control and diabetic rats.</p><h3>Discussion</h3><p dir="ltr">The findings suggest that oral <i>Spirulina platensis</i> could have a potential therapeutic role for managing induced painful diabetic neuropathy in rats.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Pain Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/jpr.s267347" target="_blank">https://dx.doi.org/10.2147/jpr.s267347</a></p>2020-09-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/jpr.s267347https://figshare.com/articles/journal_contribution/Oral_Spirulina_Platensis_Attenuates_Hyperglycemia_and_Exhibits_Antinociceptive_Effect_in_Streptozotocin-Induced_Diabetic_Neuropathy_Rat_Model/27935265CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279352652020-09-15T03:00:00Z |
| spellingShingle | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model Mohamed M Abdel-Daim (20362725) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences antinociceptive Spirulina platensis diabetes neuropathy rat |
| status_str | publishedVersion |
| title | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model |
| title_full | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model |
| title_fullStr | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model |
| title_full_unstemmed | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model |
| title_short | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model |
| title_sort | Oral Spirulina Platensis Attenuates Hyperglycemia and Exhibits Antinociceptive Effect in Streptozotocin-Induced Diabetic Neuropathy Rat Model |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences antinociceptive Spirulina platensis diabetes neuropathy rat |