Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials
<h3>Background</h3><p dir="ltr"><u>Surgical site infections</u> (SSIs) are a major cause of <u>postoperative complications</u>, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their <u>antimicrobial...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| الملخص: | <h3>Background</h3><p dir="ltr"><u>Surgical site infections</u> (SSIs) are a major cause of <u>postoperative complications</u>, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their <u>antimicrobial properties</u>, but their effectiveness in reducing SSIs remains unclear. </p><h3>Aim</h3><p dir="ltr">To evaluate the efficacy of silver-based dressings compared with non-silver dressings in preventing SSIs in <u>randomized controlled trials</u> (RCTs). </p><h3>Methods</h3><p dir="ltr">A systematic search was conducted in PubMed, Cochrane Library and Embase to identify RCTs comparing silver-based dressings with non-silver dressings for the prevention of SSIs. The study protocol was registered in PROSPERO (CRD42024592966). Meta-analysis using a random-effects model calculated pooled risk ratios (RR) with 95% confidence intervals (CI). Heterogeneity was assessed with the <i>I</i><sup><em>2</em></sup> statistic, and publication bias was evaluated through <u>funnel plots</u> and Egger's test. </p><h3>Results</h3><p dir="ltr">Twelve RCTs with 2928 participants were included in the meta-analysis. Silver-based dressings reduced the risk of SSIs by 40% compared with non-silver dressings (RR 0.60, 95% CI 0.41–0.89; <i>P</i><0.05); this difference was significant. Heterogeneity was moderate (<i>I</i><sup><em>2</em></sup>=53%). </p><h3>Conclusions</h3><p dir="ltr">Silver-based dressings reduce the risk of SSIs significantly; however, further high-quality RCTs are needed to confirm their benefits across different surgical contexts and patient populations.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Hospital Infection<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jhin.2025.04.026" target="_blank">https://dx.doi.org/10.1016/j.jhin.2025.04.026</a></p> |
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