Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials
<h3>Background</h3><p dir="ltr"><u>Surgical site infections</u> (SSIs) are a major cause of <u>postoperative complications</u>, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their <u>antimicrobial...
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2025
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| _version_ | 1864513539924819968 |
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| author | S. Younes (22254238) |
| author2 | N. Younes (22254241) S. Abunasser (22254244) F. Tamimi (8907779) G. Nasrallah (22254247) |
| author2_role | author author author author |
| author_facet | S. Younes (22254238) N. Younes (22254241) S. Abunasser (22254244) F. Tamimi (8907779) G. Nasrallah (22254247) |
| author_role | author |
| dc.creator.none.fl_str_mv | S. Younes (22254238) N. Younes (22254241) S. Abunasser (22254244) F. Tamimi (8907779) G. Nasrallah (22254247) |
| dc.date.none.fl_str_mv | 2025-07-05T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jhin.2025.04.026 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Silver-based_dressings_for_the_prevention_of_surgical_site_infections_evidence_from_randomized_trials/30135067 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Surgical site infections Silver-based dressings Antimicrobial dressings Randomized controlled trials Meta-analysis Infection prevention |
| dc.title.none.fl_str_mv | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr"><u>Surgical site infections</u> (SSIs) are a major cause of <u>postoperative complications</u>, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their <u>antimicrobial properties</u>, but their effectiveness in reducing SSIs remains unclear. </p><h3>Aim</h3><p dir="ltr">To evaluate the efficacy of silver-based dressings compared with non-silver dressings in preventing SSIs in <u>randomized controlled trials</u> (RCTs). </p><h3>Methods</h3><p dir="ltr">A systematic search was conducted in PubMed, Cochrane Library and Embase to identify RCTs comparing silver-based dressings with non-silver dressings for the prevention of SSIs. The study protocol was registered in PROSPERO (CRD42024592966). Meta-analysis using a random-effects model calculated pooled risk ratios (RR) with 95% confidence intervals (CI). Heterogeneity was assessed with the <i>I</i><sup><em>2</em></sup> statistic, and publication bias was evaluated through <u>funnel plots</u> and Egger's test. </p><h3>Results</h3><p dir="ltr">Twelve RCTs with 2928 participants were included in the meta-analysis. Silver-based dressings reduced the risk of SSIs by 40% compared with non-silver dressings (RR 0.60, 95% CI 0.41–0.89; <i>P</i><0.05); this difference was significant. Heterogeneity was moderate (<i>I</i><sup><em>2</em></sup>=53%). </p><h3>Conclusions</h3><p dir="ltr">Silver-based dressings reduce the risk of SSIs significantly; however, further high-quality RCTs are needed to confirm their benefits across different surgical contexts and patient populations.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Hospital Infection<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jhin.2025.04.026" target="_blank">https://dx.doi.org/10.1016/j.jhin.2025.04.026</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_80b0bb3900d6b26a1eab75942540fb15 |
| identifier_str_mv | 10.1016/j.jhin.2025.04.026 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30135067 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trialsS. Younes (22254238)N. Younes (22254241)S. Abunasser (22254244)F. Tamimi (8907779)G. Nasrallah (22254247)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologySurgical site infectionsSilver-based dressingsAntimicrobial dressingsRandomized controlled trialsMeta-analysisInfection prevention<h3>Background</h3><p dir="ltr"><u>Surgical site infections</u> (SSIs) are a major cause of <u>postoperative complications</u>, increasing morbidity and healthcare costs. Silver-based dressings are commonly used due to their <u>antimicrobial properties</u>, but their effectiveness in reducing SSIs remains unclear. </p><h3>Aim</h3><p dir="ltr">To evaluate the efficacy of silver-based dressings compared with non-silver dressings in preventing SSIs in <u>randomized controlled trials</u> (RCTs). </p><h3>Methods</h3><p dir="ltr">A systematic search was conducted in PubMed, Cochrane Library and Embase to identify RCTs comparing silver-based dressings with non-silver dressings for the prevention of SSIs. The study protocol was registered in PROSPERO (CRD42024592966). Meta-analysis using a random-effects model calculated pooled risk ratios (RR) with 95% confidence intervals (CI). Heterogeneity was assessed with the <i>I</i><sup><em>2</em></sup> statistic, and publication bias was evaluated through <u>funnel plots</u> and Egger's test. </p><h3>Results</h3><p dir="ltr">Twelve RCTs with 2928 participants were included in the meta-analysis. Silver-based dressings reduced the risk of SSIs by 40% compared with non-silver dressings (RR 0.60, 95% CI 0.41–0.89; <i>P</i><0.05); this difference was significant. Heterogeneity was moderate (<i>I</i><sup><em>2</em></sup>=53%). </p><h3>Conclusions</h3><p dir="ltr">Silver-based dressings reduce the risk of SSIs significantly; however, further high-quality RCTs are needed to confirm their benefits across different surgical contexts and patient populations.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Hospital Infection<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jhin.2025.04.026" target="_blank">https://dx.doi.org/10.1016/j.jhin.2025.04.026</a></p>2025-07-05T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jhin.2025.04.026https://figshare.com/articles/journal_contribution/Silver-based_dressings_for_the_prevention_of_surgical_site_infections_evidence_from_randomized_trials/30135067CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/301350672025-07-05T06:00:00Z |
| spellingShingle | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials S. Younes (22254238) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Surgical site infections Silver-based dressings Antimicrobial dressings Randomized controlled trials Meta-analysis Infection prevention |
| status_str | publishedVersion |
| title | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials |
| title_full | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials |
| title_fullStr | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials |
| title_full_unstemmed | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials |
| title_short | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials |
| title_sort | Silver-based dressings for the prevention of surgical site infections: evidence from randomized trials |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Surgical site infections Silver-based dressings Antimicrobial dressings Randomized controlled trials Meta-analysis Infection prevention |