Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes
<p dir="ltr">The current study retrospectively evaluated cytogenetic profiles, various prognostic factors, and survival outcomes in 128 acute myeloid leukemia (AML) patients (14 ≤ age ≤ 70 years) admitted to the National Center for Cancer Care and Research (NCCCR), Hamad Medical Corp...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , , |
| منشور في: |
2020
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إضافة وسم
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| _version_ | 1864513511254654976 |
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| author | Halima El Omri (14778790) |
| author2 | Ruba Yasin Taha (8984060) Adel Elomri (8984063) Nancy Kacem (8984066) Hesham Elsabah (8984069) Anil Yousaf Ellahie (8984072) Amna Gamil (8984075) Firyal Ibrahim (8984078) Dina Sameh Abdelrahman Soliman (8984081) Susanna Jane Lawson El Akiki (19022879) Zafar Nawaz (96166) Ahmad Al Sabbagh (19022882) Abdelfatteh El Omri (18278683) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Halima El Omri (14778790) Ruba Yasin Taha (8984060) Adel Elomri (8984063) Nancy Kacem (8984066) Hesham Elsabah (8984069) Anil Yousaf Ellahie (8984072) Amna Gamil (8984075) Firyal Ibrahim (8984078) Dina Sameh Abdelrahman Soliman (8984081) Susanna Jane Lawson El Akiki (19022879) Zafar Nawaz (96166) Ahmad Al Sabbagh (19022882) Abdelfatteh El Omri (18278683) |
| author_role | author |
| dc.creator.none.fl_str_mv | Halima El Omri (14778790) Ruba Yasin Taha (8984060) Adel Elomri (8984063) Nancy Kacem (8984066) Hesham Elsabah (8984069) Anil Yousaf Ellahie (8984072) Amna Gamil (8984075) Firyal Ibrahim (8984078) Dina Sameh Abdelrahman Soliman (8984081) Susanna Jane Lawson El Akiki (19022879) Zafar Nawaz (96166) Ahmad Al Sabbagh (19022882) Abdelfatteh El Omri (18278683) |
| dc.date.none.fl_str_mv | 2020-06-17T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fgene.2020.00553 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Acute_Myeloid_Leukemia_in_Qatar_2010_2016_Clinical_Biological_and_Prognostic_Factors_and_Treatment_Outcomes/26232458 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences acute myeloid leukemia cancer epidemiology cytogenetic Qatar remission survival WHO classification of AML |
| dc.title.none.fl_str_mv | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The current study retrospectively evaluated cytogenetic profiles, various prognostic factors, and survival outcomes in 128 acute myeloid leukemia (AML) patients (14 ≤ age ≤ 70 years) admitted to the National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation, Doha, Qatar, between January 2010 and December 2016. The median age at diagnosis was 43 years, and 80% were less than 60 years old; 75% of patients were male. Cytogenetic analysis was integrated into the World Health Organization 2008 classification and showed that the percentages of normal and abnormal karyotypes were similar, accounting for 48.4% of each group of patients. The AML risk stratification based on cytogenetic analysis resulted in the following distribution: 18% in the favorable risk group, 57% in the intermediate-risk group, 24% in the unfavorable risk group, and 1% unknown. Only 88 patients received therapy with curative intent; 67% achieved complete remission, increasing to 81% after inductions 1 and 2. The median overall survival (OS) and disease-free survival (DFS) in AML patients were 26.6 and 19.5 months, respectively. The 3-year OS and DFS were 40 and 36%, respectively. Prognostic factors including age, gender, white blood cell count, and risk stratification were not significantly associated with treatment outcomes, whereas response to treatment vs. failure was significantly associated with the outcome (<i>p</i> = 0.01). The current study supports the importance of cytogenetics as a useful tool in diagnosis, prognosis, and risk assessment in AML treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Genetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fgene.2020.00553" target="_blank">https://dx.doi.org/10.3389/fgene.2020.00553</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_81f2dcc138889da1e7cf32790502191d |
| identifier_str_mv | 10.3389/fgene.2020.00553 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26232458 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment OutcomesHalima El Omri (14778790)Ruba Yasin Taha (8984060)Adel Elomri (8984063)Nancy Kacem (8984066)Hesham Elsabah (8984069)Anil Yousaf Ellahie (8984072)Amna Gamil (8984075)Firyal Ibrahim (8984078)Dina Sameh Abdelrahman Soliman (8984081)Susanna Jane Lawson El Akiki (19022879)Zafar Nawaz (96166)Ahmad Al Sabbagh (19022882)Abdelfatteh El Omri (18278683)Biological sciencesGeneticsBiomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesacute myeloid leukemiacancer epidemiologycytogeneticQatarremissionsurvivalWHO classification of AML<p dir="ltr">The current study retrospectively evaluated cytogenetic profiles, various prognostic factors, and survival outcomes in 128 acute myeloid leukemia (AML) patients (14 ≤ age ≤ 70 years) admitted to the National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation, Doha, Qatar, between January 2010 and December 2016. The median age at diagnosis was 43 years, and 80% were less than 60 years old; 75% of patients were male. Cytogenetic analysis was integrated into the World Health Organization 2008 classification and showed that the percentages of normal and abnormal karyotypes were similar, accounting for 48.4% of each group of patients. The AML risk stratification based on cytogenetic analysis resulted in the following distribution: 18% in the favorable risk group, 57% in the intermediate-risk group, 24% in the unfavorable risk group, and 1% unknown. Only 88 patients received therapy with curative intent; 67% achieved complete remission, increasing to 81% after inductions 1 and 2. The median overall survival (OS) and disease-free survival (DFS) in AML patients were 26.6 and 19.5 months, respectively. The 3-year OS and DFS were 40 and 36%, respectively. Prognostic factors including age, gender, white blood cell count, and risk stratification were not significantly associated with treatment outcomes, whereas response to treatment vs. failure was significantly associated with the outcome (<i>p</i> = 0.01). The current study supports the importance of cytogenetics as a useful tool in diagnosis, prognosis, and risk assessment in AML treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Genetics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fgene.2020.00553" target="_blank">https://dx.doi.org/10.3389/fgene.2020.00553</a></p>2020-06-17T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fgene.2020.00553https://figshare.com/articles/journal_contribution/Acute_Myeloid_Leukemia_in_Qatar_2010_2016_Clinical_Biological_and_Prognostic_Factors_and_Treatment_Outcomes/26232458CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/262324582020-06-17T09:00:00Z |
| spellingShingle | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes Halima El Omri (14778790) Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences acute myeloid leukemia cancer epidemiology cytogenetic Qatar remission survival WHO classification of AML |
| status_str | publishedVersion |
| title | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes |
| title_full | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes |
| title_fullStr | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes |
| title_full_unstemmed | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes |
| title_short | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes |
| title_sort | Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes |
| topic | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences acute myeloid leukemia cancer epidemiology cytogenetic Qatar remission survival WHO classification of AML |