microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index
<h3>Background</h3><p dir="ltr">Despite several authors who have hypothesized that alterations of small noncoding RNAs (miR) are implicated in the etiopathogenesis of polycystic ovarian syndrome (PCOS), contrasting findings have been reported so far. Discrepancies in body...
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2020
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| _version_ | 1864513512424865792 |
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| author | Alexandra E. Butler (6189536) |
| author2 | Vimal Ramachandran (8774123) Thozhukat Sathyapalan (704787) Rhiannon David (8774129) Nigel J. Gooderham (704792) Manasi Benurwar (8774132) Soha R. Dargham (3613250) Shahina Hayat (8774135) S. Hani Najafi-Shoushtari (18812062) Stephen L. Atkin (6684368) |
| author2_role | author author author author author author author author author |
| author_facet | Alexandra E. Butler (6189536) Vimal Ramachandran (8774123) Thozhukat Sathyapalan (704787) Rhiannon David (8774129) Nigel J. Gooderham (704792) Manasi Benurwar (8774132) Soha R. Dargham (3613250) Shahina Hayat (8774135) S. Hani Najafi-Shoushtari (18812062) Stephen L. Atkin (6684368) |
| author_role | author |
| dc.creator.none.fl_str_mv | Alexandra E. Butler (6189536) Vimal Ramachandran (8774123) Thozhukat Sathyapalan (704787) Rhiannon David (8774129) Nigel J. Gooderham (704792) Manasi Benurwar (8774132) Soha R. Dargham (3613250) Shahina Hayat (8774135) S. Hani Najafi-Shoushtari (18812062) Stephen L. Atkin (6684368) |
| dc.date.none.fl_str_mv | 2020-04-28T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fendo.2020.00206 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/microRNA_Expression_in_Women_With_and_Without_Polycystic_Ovarian_Syndrome_Matched_for_Body_Mass_Index/26022322 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Reproductive medicine microRNA polycystic ovarian syndrome follicular phase menstrual cycle insulin resistance androgens |
| dc.title.none.fl_str_mv | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Despite several authors who have hypothesized that alterations of small noncoding RNAs (miR) are implicated in the etiopathogenesis of polycystic ovarian syndrome (PCOS), contrasting findings have been reported so far. Discrepancies in body mass index (BMI) levels may account for these differences; therefore, the aim of the present study was to determine whether miR differed in serum samples collected from age- and BMI-matched control and PCOS women.</p><h3>Methods</h3><p dir="ltr">In a cross-sectional study, miR were measured using quantitative polymerase chain reaction in 29 women with anovulatory PCOS women and 29 control women who were in the follicular phase of their menstrual cycle, from the local biobank.</p><h3>Results</h3><p dir="ltr">One hundred seventy-six miR were detected, of which 15 miR passed the false discovery rate (FDR; p < 0.05) that differed between PCOS and control women. There was no association of the top 9 miR (p < 0.02) (miR-486-5p, miR-24-3p, miR-19b-3p, miR-22-3p, miR-19a-3p, miR-339-5p, miR-185-5p, miR-101-3p, miR-let-7i-5p) with BMI, androgen levels, insulin resistance, or antimullerian hormone (AMH) in either PCOS or normal women. Ingenuity pathway assessment showed the pathways were interrelated for abnormalities of the reproductive system.</p><h3>Conclusion</h3><p dir="ltr">When the confounding influence of weight was accounted for, miR levels differed between anovulatory PCOS women and control women in the follicular phase of the menstrual cycle. Interestingly, the differing miR were associated with the pathways of reproductive abnormalities but did not associate with AMH or metabolic parameters.</p><p dir="ltr">Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index: <a href="https://dx.doi.org/10.3389/fendo.2020.00515" target="_blank">https://dx.doi.org/10.3389/fendo.2020.00515</a>, published online 30 July 2020.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2020.00206" target="_blank">https://dx.doi.org/10.3389/fendo.2020.00206</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_824d6c695d154d90256e36c561b4479e |
| identifier_str_mv | 10.3389/fendo.2020.00206 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26022322 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass IndexAlexandra E. Butler (6189536)Vimal Ramachandran (8774123)Thozhukat Sathyapalan (704787)Rhiannon David (8774129)Nigel J. Gooderham (704792)Manasi Benurwar (8774132)Soha R. Dargham (3613250)Shahina Hayat (8774135)S. Hani Najafi-Shoushtari (18812062)Stephen L. Atkin (6684368)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsReproductive medicinemicroRNApolycystic ovarian syndromefollicular phasemenstrual cycleinsulin resistanceandrogens<h3>Background</h3><p dir="ltr">Despite several authors who have hypothesized that alterations of small noncoding RNAs (miR) are implicated in the etiopathogenesis of polycystic ovarian syndrome (PCOS), contrasting findings have been reported so far. Discrepancies in body mass index (BMI) levels may account for these differences; therefore, the aim of the present study was to determine whether miR differed in serum samples collected from age- and BMI-matched control and PCOS women.</p><h3>Methods</h3><p dir="ltr">In a cross-sectional study, miR were measured using quantitative polymerase chain reaction in 29 women with anovulatory PCOS women and 29 control women who were in the follicular phase of their menstrual cycle, from the local biobank.</p><h3>Results</h3><p dir="ltr">One hundred seventy-six miR were detected, of which 15 miR passed the false discovery rate (FDR; p < 0.05) that differed between PCOS and control women. There was no association of the top 9 miR (p < 0.02) (miR-486-5p, miR-24-3p, miR-19b-3p, miR-22-3p, miR-19a-3p, miR-339-5p, miR-185-5p, miR-101-3p, miR-let-7i-5p) with BMI, androgen levels, insulin resistance, or antimullerian hormone (AMH) in either PCOS or normal women. Ingenuity pathway assessment showed the pathways were interrelated for abnormalities of the reproductive system.</p><h3>Conclusion</h3><p dir="ltr">When the confounding influence of weight was accounted for, miR levels differed between anovulatory PCOS women and control women in the follicular phase of the menstrual cycle. Interestingly, the differing miR were associated with the pathways of reproductive abnormalities but did not associate with AMH or metabolic parameters.</p><p dir="ltr">Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index: <a href="https://dx.doi.org/10.3389/fendo.2020.00515" target="_blank">https://dx.doi.org/10.3389/fendo.2020.00515</a>, published online 30 July 2020.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2020.00206" target="_blank">https://dx.doi.org/10.3389/fendo.2020.00206</a></p>2020-04-28T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fendo.2020.00206https://figshare.com/articles/journal_contribution/microRNA_Expression_in_Women_With_and_Without_Polycystic_Ovarian_Syndrome_Matched_for_Body_Mass_Index/26022322CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260223222020-04-28T09:00:00Z |
| spellingShingle | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index Alexandra E. Butler (6189536) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Reproductive medicine microRNA polycystic ovarian syndrome follicular phase menstrual cycle insulin resistance androgens |
| status_str | publishedVersion |
| title | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index |
| title_full | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index |
| title_fullStr | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index |
| title_full_unstemmed | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index |
| title_short | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index |
| title_sort | microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Reproductive medicine microRNA polycystic ovarian syndrome follicular phase menstrual cycle insulin resistance androgens |