Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis
<h3>Background</h3><p dir="ltr">Infective Endocarditis (IE) has become a significant cause of morbidity and mortality over the last two decades. Despite management advancements, mortality trends in the USA's geriatric population are unexplored. The aim of this study...
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2024
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| _version_ | 1864513543584350208 |
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| author | Hamza Ashraf (20726490) |
| author2 | Zain Ali Nadeem (20487218) Haider Ashfaq (20977895) Sophia Ahmed (817654) Ali Ashraf (31738) Abdulqadir J. Nashwan (11659453) |
| author2_role | author author author author author |
| author_facet | Hamza Ashraf (20726490) Zain Ali Nadeem (20487218) Haider Ashfaq (20977895) Sophia Ahmed (817654) Ali Ashraf (31738) Abdulqadir J. Nashwan (11659453) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hamza Ashraf (20726490) Zain Ali Nadeem (20487218) Haider Ashfaq (20977895) Sophia Ahmed (817654) Ali Ashraf (31738) Abdulqadir J. Nashwan (11659453) |
| dc.date.none.fl_str_mv | 2024-02-14T12:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cpcardiol.2024.102455 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Mortality_patterns_in_older_adults_with_infective_endocarditis_in_the_US_A_retrospective_analysis/29650976 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Health sciences Public health Infective endocarditis Mortality USA Geriatrics CDC WONDER |
| dc.title.none.fl_str_mv | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Infective Endocarditis (IE) has become a significant cause of morbidity and mortality over the last two decades. Despite management advancements, mortality trends in the USA's geriatric population are unexplored. The aim of this study was to assess the trends and regional differences in IE related mortality among geriatric patients in the USA. </p><h3>Methods</h3><p dir="ltr">We analyzed death certificates sourced from the CDC WONDER database spanning 1999 to 2020. The research targeted individuals aged 65 and older. Age-adjusted mortality rates (AAMRs) per 100,000 and annual percent change (APC), along with 95% CI, were calculated through joinpoint regression analysis. </p><h3>Results</h3><p dir="ltr">From 1999 to 2020, infective endocarditis caused 222,573 deaths, showing a declining trend (APC: -0.8361). Males had higher AAMR (26.8) than females (22.2). NH White had the highest AAMR (25.8), followed by NH American Indians or Alaska Natives (19.6). Geographically, the Midwest had the highest AAMR (27.4), followed by the Northeast (25.8). Rural areas consistently had higher AAMRs (26.6) than urban areas (23.6), while 80.16% of deaths occurring in urban settings. North Dakota, Nebraska, and Montana had the highest state AAMRs, approximately double than the states with the lowest mortality rates: Mississippi, Hawaii, California, and Massachusetts. Those aged 85 and above accounted for 42.9% of deaths. </p><h3>Conclusion</h3><p dir="ltr">IE mortality exhibited a clear pattern: rising till 2004, declining from 2004 to 2018, and increasing again till 2020. Key risk factors were male gender, Midwest residence, NH White ethnicity, and age ≥85.Targeted interventions are essential to reduce IE mortality, especially among vulnerable older populations</p><h2>Other Information</h2><p dir="ltr">Published in: Current Problems in Cardiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpcardiol.2024.102455" target="_blank">https://dx.doi.org/10.1016/j.cpcardiol.2024.102455</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_82d27fc05ad512dd50adeca2a2a713b4 |
| identifier_str_mv | 10.1016/j.cpcardiol.2024.102455 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29650976 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysisHamza Ashraf (20726490)Zain Ali Nadeem (20487218)Haider Ashfaq (20977895)Sophia Ahmed (817654)Ali Ashraf (31738)Abdulqadir J. Nashwan (11659453)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesHealth sciencesPublic healthInfective endocarditisMortalityUSAGeriatricsCDC WONDER<h3>Background</h3><p dir="ltr">Infective Endocarditis (IE) has become a significant cause of morbidity and mortality over the last two decades. Despite management advancements, mortality trends in the USA's geriatric population are unexplored. The aim of this study was to assess the trends and regional differences in IE related mortality among geriatric patients in the USA. </p><h3>Methods</h3><p dir="ltr">We analyzed death certificates sourced from the CDC WONDER database spanning 1999 to 2020. The research targeted individuals aged 65 and older. Age-adjusted mortality rates (AAMRs) per 100,000 and annual percent change (APC), along with 95% CI, were calculated through joinpoint regression analysis. </p><h3>Results</h3><p dir="ltr">From 1999 to 2020, infective endocarditis caused 222,573 deaths, showing a declining trend (APC: -0.8361). Males had higher AAMR (26.8) than females (22.2). NH White had the highest AAMR (25.8), followed by NH American Indians or Alaska Natives (19.6). Geographically, the Midwest had the highest AAMR (27.4), followed by the Northeast (25.8). Rural areas consistently had higher AAMRs (26.6) than urban areas (23.6), while 80.16% of deaths occurring in urban settings. North Dakota, Nebraska, and Montana had the highest state AAMRs, approximately double than the states with the lowest mortality rates: Mississippi, Hawaii, California, and Massachusetts. Those aged 85 and above accounted for 42.9% of deaths. </p><h3>Conclusion</h3><p dir="ltr">IE mortality exhibited a clear pattern: rising till 2004, declining from 2004 to 2018, and increasing again till 2020. Key risk factors were male gender, Midwest residence, NH White ethnicity, and age ≥85.Targeted interventions are essential to reduce IE mortality, especially among vulnerable older populations</p><h2>Other Information</h2><p dir="ltr">Published in: Current Problems in Cardiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpcardiol.2024.102455" target="_blank">https://dx.doi.org/10.1016/j.cpcardiol.2024.102455</a></p>2024-02-14T12:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cpcardiol.2024.102455https://figshare.com/articles/journal_contribution/Mortality_patterns_in_older_adults_with_infective_endocarditis_in_the_US_A_retrospective_analysis/29650976CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/296509762024-02-14T12:00:00Z |
| spellingShingle | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis Hamza Ashraf (20726490) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Health sciences Public health Infective endocarditis Mortality USA Geriatrics CDC WONDER |
| status_str | publishedVersion |
| title | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis |
| title_full | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis |
| title_fullStr | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis |
| title_full_unstemmed | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis |
| title_short | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis |
| title_sort | Mortality patterns in older adults with infective endocarditis in the US: A retrospective analysis |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Health sciences Public health Infective endocarditis Mortality USA Geriatrics CDC WONDER |