The STIM1 Phosphorylation Saga
<p dir="ltr">Store-operated Ca<sup>2+</sup> entry (SOCE) is a Ca<sup>2+</sup> influx pathway present in practically every cell type in metazoans and mediates a variety of physiological functions. Defects in SOCE are associated with immunodeficiencies and defec...
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2022
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| _version_ | 1864513535800770560 |
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| author | Fang Yu (156838) |
| author2 | Khaled Machaca (194372) |
| author2_role | author |
| author_facet | Fang Yu (156838) Khaled Machaca (194372) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fang Yu (156838) Khaled Machaca (194372) |
| dc.date.none.fl_str_mv | 2022-05-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ceca.2022.102551 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_STIM1_Phosphorylation_Saga/24745809 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Phosphorylation Store operated Ca entry STIM1 Mitosis Meiosis oocyte Endoplasmic Reticulum Cell migration ERK/MAPK Cdk1 AMPK Serine/threonine Tyrosine |
| dc.title.none.fl_str_mv | The STIM1 Phosphorylation Saga |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Store-operated Ca<sup>2+</sup> entry (SOCE) is a Ca<sup>2+</sup> influx pathway present in practically every cell type in metazoans and mediates a variety of physiological functions. Defects in SOCE are associated with immunodeficiencies and defects in skeletal muscle development and function. The molecular machinery underpinning SOCE can be complex and cell type specific, however the minimal functional SOCE unit consists of the endoplasmic reticulum (ER) Ca<sup>2+</sup> sensor STIM1 and the plasma membrane (PM) Ca<sup>2+</sup>-selective channel Orai1. STIM1 localizes to ER-PM contact sites (CS) following store depletion, where it recruits and gates Orai1. STIM1 is a phosphoprotein that is hyper-phosphorylated during cell division. STIM1 phosphorylation has been implicated in several functions, including modulation of cellular metabolism, SOCE inactivation during M-phase, ER segregation during mitosis, modulation of SOCE levels, and cell migration. However, the role of STIM1 phosphorylation in the majority of these processes is controversial bringing into question the physiological function of STIM1 phosphorylation, if any. Here we review the role and modulation of STIM1 phosphorylation under various conditions and argue that except for the modulation of energy metabolism, the physiological function of STIM1 phosphorylation remains unclear.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Calcium<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ceca.2022.102551" target="_blank">https://dx.doi.org/10.1016/j.ceca.2022.102551</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_833829cbb8e5ee9b837f9cb04d853341 |
| identifier_str_mv | 10.1016/j.ceca.2022.102551 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24745809 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The STIM1 Phosphorylation SagaFang Yu (156838)Khaled Machaca (194372)Biological sciencesBiochemistry and cell biologyPhosphorylationStore operated Ca entrySTIM1MitosisMeiosisoocyteEndoplasmic ReticulumCell migrationERK/MAPKCdk1AMPKSerine/threonineTyrosine<p dir="ltr">Store-operated Ca<sup>2+</sup> entry (SOCE) is a Ca<sup>2+</sup> influx pathway present in practically every cell type in metazoans and mediates a variety of physiological functions. Defects in SOCE are associated with immunodeficiencies and defects in skeletal muscle development and function. The molecular machinery underpinning SOCE can be complex and cell type specific, however the minimal functional SOCE unit consists of the endoplasmic reticulum (ER) Ca<sup>2+</sup> sensor STIM1 and the plasma membrane (PM) Ca<sup>2+</sup>-selective channel Orai1. STIM1 localizes to ER-PM contact sites (CS) following store depletion, where it recruits and gates Orai1. STIM1 is a phosphoprotein that is hyper-phosphorylated during cell division. STIM1 phosphorylation has been implicated in several functions, including modulation of cellular metabolism, SOCE inactivation during M-phase, ER segregation during mitosis, modulation of SOCE levels, and cell migration. However, the role of STIM1 phosphorylation in the majority of these processes is controversial bringing into question the physiological function of STIM1 phosphorylation, if any. Here we review the role and modulation of STIM1 phosphorylation under various conditions and argue that except for the modulation of energy metabolism, the physiological function of STIM1 phosphorylation remains unclear.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Calcium<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ceca.2022.102551" target="_blank">https://dx.doi.org/10.1016/j.ceca.2022.102551</a></p>2022-05-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ceca.2022.102551https://figshare.com/articles/journal_contribution/The_STIM1_Phosphorylation_Saga/24745809CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247458092022-05-01T00:00:00Z |
| spellingShingle | The STIM1 Phosphorylation Saga Fang Yu (156838) Biological sciences Biochemistry and cell biology Phosphorylation Store operated Ca entry STIM1 Mitosis Meiosis oocyte Endoplasmic Reticulum Cell migration ERK/MAPK Cdk1 AMPK Serine/threonine Tyrosine |
| status_str | publishedVersion |
| title | The STIM1 Phosphorylation Saga |
| title_full | The STIM1 Phosphorylation Saga |
| title_fullStr | The STIM1 Phosphorylation Saga |
| title_full_unstemmed | The STIM1 Phosphorylation Saga |
| title_short | The STIM1 Phosphorylation Saga |
| title_sort | The STIM1 Phosphorylation Saga |
| topic | Biological sciences Biochemistry and cell biology Phosphorylation Store operated Ca entry STIM1 Mitosis Meiosis oocyte Endoplasmic Reticulum Cell migration ERK/MAPK Cdk1 AMPK Serine/threonine Tyrosine |