Emerging understandings of the role of exosomes in atherosclerosis
<p dir="ltr">Atherosclerosis remains a major contributor to cardiovascular disease, the leading cause of global morbidity and mortality. Despite the elucidation of several molecular, biochemical, and cellular aspects that contribute to the etio‐pathogenesis of atherosclerosis, much r...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513537953497088 |
|---|---|
| author | Zena Wehbe (16328843) |
| author2 | Maya Wehbe (11286370) Ali Al Khatib (22391896) Ali H. Dakroub (22303819) Gianfranco Pintus (91638) Firas Kobeissy (307253) Ali H. Eid (5461829) |
| author2_role | author author author author author author |
| author_facet | Zena Wehbe (16328843) Maya Wehbe (11286370) Ali Al Khatib (22391896) Ali H. Dakroub (22303819) Gianfranco Pintus (91638) Firas Kobeissy (307253) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zena Wehbe (16328843) Maya Wehbe (11286370) Ali Al Khatib (22391896) Ali H. Dakroub (22303819) Gianfranco Pintus (91638) Firas Kobeissy (307253) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2024-10-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/jcp.31454 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Emerging_understandings_of_the_role_of_exosomes_in_atherosclerosis/30305914 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Immunology atherogenesis cardiovascular disease drug discovery extracellular vesicles phenotypic switch vascular smooth muscle cells |
| dc.title.none.fl_str_mv | Emerging understandings of the role of exosomes in atherosclerosis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Atherosclerosis remains a major contributor to cardiovascular disease, the leading cause of global morbidity and mortality. Despite the elucidation of several molecular, biochemical, and cellular aspects that contribute to the etio‐pathogenesis of atherosclerosis, much remains to be understood about the onset and progression of this disease. Emerging evidence supports a role for exosomes in the cellular basis of atherosclerosis. Indeed, exosomes of activated monocytes seem to accentuate a positive feedback loop that promotes recruitment of pro‐inflammatory leukocytes. Moreover, in addition to their role in promoting proliferation and invasion of vascular smooth muscle cells, exosomes can also induce neovascularization within lesions and increase endothelial permeability, two important features of fibrous plaques. Depending on their sources and cargo, exosomes can also induce clot formation and contribute to other hallmarks of atherosclerosis. Taken together, it is becoming increasingly evident that a better understanding of exosome biology is integral to elucidating the pathogenesis of atherosclerosis, and may thus provide insight into a potentially new therapeutic target for this disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular Physiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jcp.31454" target="_blank">https://dx.doi.org/10.1002/jcp.31454</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_838ef9a33430e51beee1d3c923070072 |
| identifier_str_mv | 10.1002/jcp.31454 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30305914 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Emerging understandings of the role of exosomes in atherosclerosisZena Wehbe (16328843)Maya Wehbe (11286370)Ali Al Khatib (22391896)Ali H. Dakroub (22303819)Gianfranco Pintus (91638)Firas Kobeissy (307253)Ali H. Eid (5461829)Biomedical and clinical sciencesCardiovascular medicine and haematologyImmunologyatherogenesiscardiovascular diseasedrug discoveryextracellular vesiclesphenotypic switchvascular smooth muscle cells<p dir="ltr">Atherosclerosis remains a major contributor to cardiovascular disease, the leading cause of global morbidity and mortality. Despite the elucidation of several molecular, biochemical, and cellular aspects that contribute to the etio‐pathogenesis of atherosclerosis, much remains to be understood about the onset and progression of this disease. Emerging evidence supports a role for exosomes in the cellular basis of atherosclerosis. Indeed, exosomes of activated monocytes seem to accentuate a positive feedback loop that promotes recruitment of pro‐inflammatory leukocytes. Moreover, in addition to their role in promoting proliferation and invasion of vascular smooth muscle cells, exosomes can also induce neovascularization within lesions and increase endothelial permeability, two important features of fibrous plaques. Depending on their sources and cargo, exosomes can also induce clot formation and contribute to other hallmarks of atherosclerosis. Taken together, it is becoming increasingly evident that a better understanding of exosome biology is integral to elucidating the pathogenesis of atherosclerosis, and may thus provide insight into a potentially new therapeutic target for this disease.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular Physiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jcp.31454" target="_blank">https://dx.doi.org/10.1002/jcp.31454</a></p>2024-10-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/jcp.31454https://figshare.com/articles/journal_contribution/Emerging_understandings_of_the_role_of_exosomes_in_atherosclerosis/30305914CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/303059142024-10-06T03:00:00Z |
| spellingShingle | Emerging understandings of the role of exosomes in atherosclerosis Zena Wehbe (16328843) Biomedical and clinical sciences Cardiovascular medicine and haematology Immunology atherogenesis cardiovascular disease drug discovery extracellular vesicles phenotypic switch vascular smooth muscle cells |
| status_str | publishedVersion |
| title | Emerging understandings of the role of exosomes in atherosclerosis |
| title_full | Emerging understandings of the role of exosomes in atherosclerosis |
| title_fullStr | Emerging understandings of the role of exosomes in atherosclerosis |
| title_full_unstemmed | Emerging understandings of the role of exosomes in atherosclerosis |
| title_short | Emerging understandings of the role of exosomes in atherosclerosis |
| title_sort | Emerging understandings of the role of exosomes in atherosclerosis |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Immunology atherogenesis cardiovascular disease drug discovery extracellular vesicles phenotypic switch vascular smooth muscle cells |