Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review
<p dir="ltr">Cutaneous metastases of choriocarcinoma are rare. They may indicate poor prognosis and resistance to chemotherapy. In this report, we present a case of a 25-year-old man who presented with central pleuritic chest pain and right upper arm mass for about a week. The patien...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2020
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إضافة وسم
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| _version_ | 1864513566155997184 |
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| author | Khaled A. Murshed (14151927) |
| author2 | Aladdin Kanbour (14442123) Mohammed Akhtar (9954129) Samir Al Hyassat (14777572) |
| author2_role | author author author |
| author_facet | Khaled A. Murshed (14151927) Aladdin Kanbour (14442123) Mohammed Akhtar (9954129) Samir Al Hyassat (14777572) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khaled A. Murshed (14151927) Aladdin Kanbour (14442123) Mohammed Akhtar (9954129) Samir Al Hyassat (14777572) |
| dc.date.none.fl_str_mv | 2020-06-15T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/cup.13777 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Primary_mediastinal_choriocarcinoma_presenting_as_cutaneous_metastasis_with_resistance_to_chemotherapy_case_report_and_literature_review/22258477 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Dermatology Histology Pathology and Forensic Medicine metastatic choriocarcinoma brain lesions |
| dc.title.none.fl_str_mv | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cutaneous metastases of choriocarcinoma are rare. They may indicate poor prognosis and resistance to chemotherapy. In this report, we present a case of a 25-year-old man who presented with central pleuritic chest pain and right upper arm mass for about a week. The patient also had significant weight loss during the last 5 months along with an episode of generalized seizure. Chest computed tomography scan revealed an 8 cm anterior mediastinal mass. A skin punch biopsy from the right upper arm mass revealed a malignant neoplasm with morphology consistent with metastatic choriocarcinoma. Further work-up revealed multiple lung and brain lesions. Ultrasound of the testes revealed no abnormalities. Several chemotherapy regimens were tried; however, there was no response and the disease showed progression. The patient died 6 months after initial presentation.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cutaneous Pathology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/cup.13777" target="_blank">http://dx.doi.org/10.1111/cup.13777</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_83d502ff322e2b1b2197dbe72f6395c3 |
| identifier_str_mv | 10.1111/cup.13777 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258477 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature reviewKhaled A. Murshed (14151927)Aladdin Kanbour (14442123)Mohammed Akhtar (9954129)Samir Al Hyassat (14777572)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisDermatologyHistologyPathology and Forensic Medicinemetastatic choriocarcinomabrain lesions<p dir="ltr">Cutaneous metastases of choriocarcinoma are rare. They may indicate poor prognosis and resistance to chemotherapy. In this report, we present a case of a 25-year-old man who presented with central pleuritic chest pain and right upper arm mass for about a week. The patient also had significant weight loss during the last 5 months along with an episode of generalized seizure. Chest computed tomography scan revealed an 8 cm anterior mediastinal mass. A skin punch biopsy from the right upper arm mass revealed a malignant neoplasm with morphology consistent with metastatic choriocarcinoma. Further work-up revealed multiple lung and brain lesions. Ultrasound of the testes revealed no abnormalities. Several chemotherapy regimens were tried; however, there was no response and the disease showed progression. The patient died 6 months after initial presentation.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cutaneous Pathology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/cup.13777" target="_blank">http://dx.doi.org/10.1111/cup.13777</a></p>2020-06-15T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/cup.13777https://figshare.com/articles/journal_contribution/Primary_mediastinal_choriocarcinoma_presenting_as_cutaneous_metastasis_with_resistance_to_chemotherapy_case_report_and_literature_review/22258477CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222584772020-06-15T21:00:00Z |
| spellingShingle | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review Khaled A. Murshed (14151927) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Dermatology Histology Pathology and Forensic Medicine metastatic choriocarcinoma brain lesions |
| status_str | publishedVersion |
| title | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review |
| title_full | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review |
| title_fullStr | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review |
| title_full_unstemmed | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review |
| title_short | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review |
| title_sort | Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Dermatology Histology Pathology and Forensic Medicine metastatic choriocarcinoma brain lesions |