Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma
<p dir="ltr">Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy that commonly affects older individuals with a high mortality rate. The treatment of MCC is still a challenge. The presence of Merkel cell polyomavirus (MCPyV or MCV) is a major caus...
محفوظ في:
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| مؤلفون آخرون: | , |
| منشور في: |
2023
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| _version_ | 1864513507546890240 |
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| author | Aayami Jaguri (19467748) |
| author2 | Martin Steinhoff (5340194) Aamir Ahmad (233201) |
| author2_role | author author |
| author_facet | Aayami Jaguri (19467748) Martin Steinhoff (5340194) Aamir Ahmad (233201) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aayami Jaguri (19467748) Martin Steinhoff (5340194) Aamir Ahmad (233201) |
| dc.date.none.fl_str_mv | 2023-08-12T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers15164075 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Epigenetic_m6A_RNA_Modification_Reader_YTHDF1_in_Merkel_Cell_Carcinoma/26808319 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Microbiology Biomedical and clinical sciences Oncology and carcinogenesis Merkel Cell Carcinoma (MCC) Neuroendocrine Tumor Polyomavirus Oncogenesis T Antigens mRNA Modification Simian Virus 40 (SV40) |
| dc.title.none.fl_str_mv | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy that commonly affects older individuals with a high mortality rate. The treatment of MCC is still a challenge. The presence of Merkel cell polyomavirus (MCPyV or MCV) is a major causative factor for the disease, associated with approximately 80% of MCC cases. The only known polyomavirus virus to play a role in tumorigenesis, MCPyV, is a double-stranded DNA virus from the Polyomaviridae family of viruses and is known to target dermal fibroblasts. It induces oncogenesis by clonally integrating into the MCC tumor cell genome and expressing its oncogenic T antigens: large T (lT), small T (sT), and 57 kT antigens.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers15164075" target="_blank">https://dx.doi.org/10.3390/cancers15164075</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_84cf50aac2cf4e3e1860760c64bfeb22 |
| identifier_str_mv | 10.3390/cancers15164075 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26808319 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell CarcinomaAayami Jaguri (19467748)Martin Steinhoff (5340194)Aamir Ahmad (233201)Biological sciencesGeneticsMicrobiologyBiomedical and clinical sciencesOncology and carcinogenesisMerkel Cell Carcinoma (MCC)Neuroendocrine TumorPolyomavirusOncogenesisT AntigensmRNA ModificationSimian Virus 40 (SV40)<p dir="ltr">Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy that commonly affects older individuals with a high mortality rate. The treatment of MCC is still a challenge. The presence of Merkel cell polyomavirus (MCPyV or MCV) is a major causative factor for the disease, associated with approximately 80% of MCC cases. The only known polyomavirus virus to play a role in tumorigenesis, MCPyV, is a double-stranded DNA virus from the Polyomaviridae family of viruses and is known to target dermal fibroblasts. It induces oncogenesis by clonally integrating into the MCC tumor cell genome and expressing its oncogenic T antigens: large T (lT), small T (sT), and 57 kT antigens.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers15164075" target="_blank">https://dx.doi.org/10.3390/cancers15164075</a></p>2023-08-12T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers15164075https://figshare.com/articles/journal_contribution/Epigenetic_m6A_RNA_Modification_Reader_YTHDF1_in_Merkel_Cell_Carcinoma/26808319CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/268083192023-08-12T09:00:00Z |
| spellingShingle | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma Aayami Jaguri (19467748) Biological sciences Genetics Microbiology Biomedical and clinical sciences Oncology and carcinogenesis Merkel Cell Carcinoma (MCC) Neuroendocrine Tumor Polyomavirus Oncogenesis T Antigens mRNA Modification Simian Virus 40 (SV40) |
| status_str | publishedVersion |
| title | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma |
| title_full | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma |
| title_fullStr | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma |
| title_full_unstemmed | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma |
| title_short | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma |
| title_sort | Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma |
| topic | Biological sciences Genetics Microbiology Biomedical and clinical sciences Oncology and carcinogenesis Merkel Cell Carcinoma (MCC) Neuroendocrine Tumor Polyomavirus Oncogenesis T Antigens mRNA Modification Simian Virus 40 (SV40) |