SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study
<h3>Background</h3><p dir="ltr">We investigated the contribution of age, coexisting medical conditions, sex, and vaccination to incidence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and of severe, critical, or fatal COVID‐19 in older adults s...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , , , , , , , |
| منشور في: |
2023
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إضافة وسم
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| _version_ | 1864513555757268992 |
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| author | Mai A. Mahmoud (9620657) |
| author2 | Houssein H. Ayoub (9262512) Peter Coyle (787159) Patrick Tang (239534) Mohammad R. Hasan (13777597) Hadi M. Yassine (4675846) Asmaa A. Al Thani (10494576) Zaina Al‐Kanaani (17991526) Einas Al‐Kuwari (14779336) Andrew Jeremijenko (11506565) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hanan F. Abdul‐Rahim (17991529) Gheyath K. Nasrallah (9200525) Mohamed Ghaith Al‐Kuwari (17991532) Adeel A. Butt (3697705) Hamad Eid Al‐Romaihi (17991535) Mohamed H. Al‐Thani (17991538) Abdullatif Al‐Khal (14779372) Roberto Bertollini (9538620) Laith J. Abu‐Raddad (17991541) Hiam Chemaitelly (439114) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Mai A. Mahmoud (9620657) Houssein H. Ayoub (9262512) Peter Coyle (787159) Patrick Tang (239534) Mohammad R. Hasan (13777597) Hadi M. Yassine (4675846) Asmaa A. Al Thani (10494576) Zaina Al‐Kanaani (17991526) Einas Al‐Kuwari (14779336) Andrew Jeremijenko (11506565) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hanan F. Abdul‐Rahim (17991529) Gheyath K. Nasrallah (9200525) Mohamed Ghaith Al‐Kuwari (17991532) Adeel A. Butt (3697705) Hamad Eid Al‐Romaihi (17991535) Mohamed H. Al‐Thani (17991538) Abdullatif Al‐Khal (14779372) Roberto Bertollini (9538620) Laith J. Abu‐Raddad (17991541) Hiam Chemaitelly (439114) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mai A. Mahmoud (9620657) Houssein H. Ayoub (9262512) Peter Coyle (787159) Patrick Tang (239534) Mohammad R. Hasan (13777597) Hadi M. Yassine (4675846) Asmaa A. Al Thani (10494576) Zaina Al‐Kanaani (17991526) Einas Al‐Kuwari (14779336) Andrew Jeremijenko (11506565) Anvar Hassan Kaleeckal (11847034) Ali Nizar Latif (11570540) Riyazuddin Mohammad Shaik (11847037) Hanan F. Abdul‐Rahim (17991529) Gheyath K. Nasrallah (9200525) Mohamed Ghaith Al‐Kuwari (17991532) Adeel A. Butt (3697705) Hamad Eid Al‐Romaihi (17991535) Mohamed H. Al‐Thani (17991538) Abdullatif Al‐Khal (14779372) Roberto Bertollini (9538620) Laith J. Abu‐Raddad (17991541) Hiam Chemaitelly (439114) |
| dc.date.none.fl_str_mv | 2023-11-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/irv.13224 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/SARS_CoV_2_infection_and_effects_of_age_sex_comorbidity_and_vaccination_among_older_individuals_A_national_cohort_study/25249147 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology COVID-19 geriatrics immunity older adults Qatar vaccination |
| dc.title.none.fl_str_mv | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">We investigated the contribution of age, coexisting medical conditions, sex, and vaccination to incidence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and of severe, critical, or fatal COVID‐19 in older adults since pandemic onset.</p><h3>Methods</h3><p dir="ltr">A national retrospective cohort study was conducted in the population of Qatar aged ≥50 years between February 5, 2020 and June 15, 2023. Adjusted hazard ratios (AHRs) for infection and for severe coronavirus disease 2019 (COVID‐19) outcomes were estimated through Cox regression models.</p><h3>Results</h3><p dir="ltr">Cumulative incidence was 25.01% (95% confidence interval [CI]: 24.86–25.15%) for infection and 1.59% (95% CI: 1.55–1.64%) for severe, critical, or fatal COVID‐19 after a follow‐up duration of 40.9 months. Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. Risk of infection was reduced with primary‐series vaccination (AHR: 0.91, 95% CI: 0.90–0.93) and further with first booster vaccination (AHR: 0.75, 95% CI: 0.74–0.77). Risk of severe, critical, or fatal COVID‐19 increased exponentially with age and linearly with coexisting conditions. AHRs for severe, critical, or fatal COVID‐19 were 0.86 (95% CI: 0.7–0.97) for one dose, 0.15 (95% CI: 0.13–0.17) for primary‐series vaccination, and 0.11 (95% CI: 0.08–0.14) for first booster vaccination. Sensitivity analysis restricted to only Qataris yielded similar results.</p><h3>Conclusion</h3><p dir="ltr">Incidence of severe COVID‐19 in older adults followed a dynamic pattern shaped by infection incidence, variant severity, and population immunity. Age, sex, and coexisting conditions were strong determinants of infection severity. Vaccine protection against severe outcomes showed a dose–response relationship, highlighting the importance of booster vaccination for older adults.</p><h2>Other Information</h2><p dir="ltr">Published in: Influenza and Other Respiratory Viruses<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/irv.13224" target="_blank">https://dx.doi.org/10.1111/irv.13224</a></p><p dir="ltr">Additional institutions affiliated with: WHO Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis - WCM-Q, Hamad Bin Khalifa University, Qatar University Health - QU, </p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8541ecbced4020c42238bde5fc8a7ebf |
| identifier_str_mv | 10.1111/irv.13224 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25249147 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort studyMai A. Mahmoud (9620657)Houssein H. Ayoub (9262512)Peter Coyle (787159)Patrick Tang (239534)Mohammad R. Hasan (13777597)Hadi M. Yassine (4675846)Asmaa A. Al Thani (10494576)Zaina Al‐Kanaani (17991526)Einas Al‐Kuwari (14779336)Andrew Jeremijenko (11506565)Anvar Hassan Kaleeckal (11847034)Ali Nizar Latif (11570540)Riyazuddin Mohammad Shaik (11847037)Hanan F. Abdul‐Rahim (17991529)Gheyath K. Nasrallah (9200525)Mohamed Ghaith Al‐Kuwari (17991532)Adeel A. Butt (3697705)Hamad Eid Al‐Romaihi (17991535)Mohamed H. Al‐Thani (17991538)Abdullatif Al‐Khal (14779372)Roberto Bertollini (9538620)Laith J. Abu‐Raddad (17991541)Hiam Chemaitelly (439114)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologyCOVID-19geriatricsimmunityolder adultsQatarvaccination<h3>Background</h3><p dir="ltr">We investigated the contribution of age, coexisting medical conditions, sex, and vaccination to incidence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and of severe, critical, or fatal COVID‐19 in older adults since pandemic onset.</p><h3>Methods</h3><p dir="ltr">A national retrospective cohort study was conducted in the population of Qatar aged ≥50 years between February 5, 2020 and June 15, 2023. Adjusted hazard ratios (AHRs) for infection and for severe coronavirus disease 2019 (COVID‐19) outcomes were estimated through Cox regression models.</p><h3>Results</h3><p dir="ltr">Cumulative incidence was 25.01% (95% confidence interval [CI]: 24.86–25.15%) for infection and 1.59% (95% CI: 1.55–1.64%) for severe, critical, or fatal COVID‐19 after a follow‐up duration of 40.9 months. Risk of infection varied minimally by age and sex but increased significantly with coexisting conditions. Risk of infection was reduced with primary‐series vaccination (AHR: 0.91, 95% CI: 0.90–0.93) and further with first booster vaccination (AHR: 0.75, 95% CI: 0.74–0.77). Risk of severe, critical, or fatal COVID‐19 increased exponentially with age and linearly with coexisting conditions. AHRs for severe, critical, or fatal COVID‐19 were 0.86 (95% CI: 0.7–0.97) for one dose, 0.15 (95% CI: 0.13–0.17) for primary‐series vaccination, and 0.11 (95% CI: 0.08–0.14) for first booster vaccination. Sensitivity analysis restricted to only Qataris yielded similar results.</p><h3>Conclusion</h3><p dir="ltr">Incidence of severe COVID‐19 in older adults followed a dynamic pattern shaped by infection incidence, variant severity, and population immunity. Age, sex, and coexisting conditions were strong determinants of infection severity. Vaccine protection against severe outcomes showed a dose–response relationship, highlighting the importance of booster vaccination for older adults.</p><h2>Other Information</h2><p dir="ltr">Published in: Influenza and Other Respiratory Viruses<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/irv.13224" target="_blank">https://dx.doi.org/10.1111/irv.13224</a></p><p dir="ltr">Additional institutions affiliated with: WHO Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis - WCM-Q, Hamad Bin Khalifa University, Qatar University Health - QU, </p>2023-11-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/irv.13224https://figshare.com/articles/journal_contribution/SARS_CoV_2_infection_and_effects_of_age_sex_comorbidity_and_vaccination_among_older_individuals_A_national_cohort_study/25249147CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252491472023-11-01T00:00:00Z |
| spellingShingle | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study Mai A. Mahmoud (9620657) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology COVID-19 geriatrics immunity older adults Qatar vaccination |
| status_str | publishedVersion |
| title | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study |
| title_full | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study |
| title_fullStr | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study |
| title_full_unstemmed | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study |
| title_short | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study |
| title_sort | SARS‐CoV‐2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology COVID-19 geriatrics immunity older adults Qatar vaccination |