Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity
<div><p>Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined by the absence of estrogen and progesterone receptors and...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2019
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إضافة وسم
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| _version_ | 1864513520347906048 |
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| author | Ishita Gupta (9203073) |
| author2 | Rasha Sareyeldin (18171289) Israa Al-Hashimi (18131374) Hamda A. Al-Thawadi (18131377) Halema Al Farsi (18171292) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| author2_role | author author author author author author |
| author_facet | Ishita Gupta (9203073) Rasha Sareyeldin (18171289) Israa Al-Hashimi (18131374) Hamda A. Al-Thawadi (18131377) Halema Al Farsi (18171292) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ishita Gupta (9203073) Rasha Sareyeldin (18171289) Israa Al-Hashimi (18131374) Hamda A. Al-Thawadi (18131377) Halema Al Farsi (18171292) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| dc.date.none.fl_str_mv | 2019-03-13T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers11030363 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Triple_Negative_Breast_Cancer_Profile_from_Gene_to_microRNA_in_Relation_to_Ethnicity/25424998 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis breast cancer triple negative breast cancer biomarkers microarray gene expression profiling miRNA |
| dc.title.none.fl_str_mv | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined by the absence of estrogen and progesterone receptors and the lack of HER-2 expression; this subgroup accounts for ~15% of all breast cancers and exhibits the most aggressive metastatic behavior. Currently, very limited targeted therapies exist for the treatment of patients with TNBCs. On the other hand, it is important to highlight that knowledge of the molecular biology of breast cancer has recently changed the decision-making process regarding the course of cancer therapies. Thus, a number of new techniques, such as gene profiling and sequencing, proteomics, and microRNA analysis have been used to explore human breast carcinogenesis and metastasis including TNBC, which consequently could lead to new therapies. Nevertheless, based on evidence thus far, genomics profiles (gene and miRNA) can differ from one geographic location to another as well as in different ethnic groups. This review provides a comprehensive and updated information on the genomics profile alterations associated with TNBC pathogenesis associated with different ethnic backgrounds.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cancers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers11030363" target="_blank">https://dx.doi.org/10.3390/cancers11030363</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_85cdae7012eed34da8ac517e487fd420 |
| identifier_str_mv | 10.3390/cancers11030363 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25424998 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to EthnicityIshita Gupta (9203073)Rasha Sareyeldin (18171289)Israa Al-Hashimi (18131374)Hamda A. Al-Thawadi (18131377)Halema Al Farsi (18171292)Semir Vranic (3353012)Ala-Eddin Al Moustafa (14153205)Biomedical and clinical sciencesOncology and carcinogenesisbreast cancertriple negative breast cancerbiomarkersmicroarraygene expression profilingmiRNA<div><p>Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined by the absence of estrogen and progesterone receptors and the lack of HER-2 expression; this subgroup accounts for ~15% of all breast cancers and exhibits the most aggressive metastatic behavior. Currently, very limited targeted therapies exist for the treatment of patients with TNBCs. On the other hand, it is important to highlight that knowledge of the molecular biology of breast cancer has recently changed the decision-making process regarding the course of cancer therapies. Thus, a number of new techniques, such as gene profiling and sequencing, proteomics, and microRNA analysis have been used to explore human breast carcinogenesis and metastasis including TNBC, which consequently could lead to new therapies. Nevertheless, based on evidence thus far, genomics profiles (gene and miRNA) can differ from one geographic location to another as well as in different ethnic groups. This review provides a comprehensive and updated information on the genomics profile alterations associated with TNBC pathogenesis associated with different ethnic backgrounds.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cancers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers11030363" target="_blank">https://dx.doi.org/10.3390/cancers11030363</a></p>2019-03-13T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers11030363https://figshare.com/articles/journal_contribution/Triple_Negative_Breast_Cancer_Profile_from_Gene_to_microRNA_in_Relation_to_Ethnicity/25424998CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/254249982019-03-13T03:00:00Z |
| spellingShingle | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity Ishita Gupta (9203073) Biomedical and clinical sciences Oncology and carcinogenesis breast cancer triple negative breast cancer biomarkers microarray gene expression profiling miRNA |
| status_str | publishedVersion |
| title | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity |
| title_full | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity |
| title_fullStr | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity |
| title_full_unstemmed | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity |
| title_short | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity |
| title_sort | Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis breast cancer triple negative breast cancer biomarkers microarray gene expression profiling miRNA |