A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report
<h3>Key Clinical Message</h3><p dir="ltr">Graves's disease must be treated promptly to avoid serious sequelae such as cardiomyopathy, liver injury, and pancytopenia. Early initiation of antithyroid medications and beta blockers could not be overrated even in the pres...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2024
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513543057965056 |
|---|---|
| author | Mohamed Kamal Sabra (17075230) |
| author2 | Anwar Joudeh (12234713) Mahmoud Al Niserat (21841439) Riyadh Hammamy (14777230) |
| author2_role | author author author |
| author_facet | Mohamed Kamal Sabra (17075230) Anwar Joudeh (12234713) Mahmoud Al Niserat (21841439) Riyadh Hammamy (14777230) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohamed Kamal Sabra (17075230) Anwar Joudeh (12234713) Mahmoud Al Niserat (21841439) Riyadh Hammamy (14777230) |
| dc.date.none.fl_str_mv | 2024-04-24T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/ccr3.8698 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_young_patient_with_Graves_disease_presenting_with_a_triad_of_heart_failure_pancytopenia_and_jaundice_A_case_report/29714984 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics cardiomyopathy Grave's disease jaundice pancytopenia |
| dc.title.none.fl_str_mv | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Key Clinical Message</h3><p dir="ltr">Graves's disease must be treated promptly to avoid serious sequelae such as cardiomyopathy, liver injury, and pancytopenia. Early initiation of antithyroid medications and beta blockers could not be overrated even in the presence of these complications.</p><p dir="ltr">Graves' disease causes a large spectrum of clinical manifestations. Delayed diagnosis and management of Graves' disease could lead to serious systemic sequelae. We describe a case of a young man who presented with progressive cough, increased abdominal girth and ankle swelling for a few months. On examination, he had jaundice, bilateral exophthalmos, diffuse goiter, ascites, and significant lower limb edema. Laboratory investigations showed increased Thyroxin level with a suppressed thyroid stimulating hormone and positive anti‐thyrotropin receptor antibodies. Also, the patient had pancytopenia, coagulopathy and cholestatic pattern of elevated liver enzymes. Echocardiography demonstrated mildly reduced left ventricular function with diastolic dysfunction, but electrocardiogram did not show atrial fibrillation. Despite the concerns about using antithyroid medications in patients with impaired liver function tests and pancytopenia, the patient improved dramatically without worsening of his hematological or biochemical parameters. Early initiation of antithyroid medications and beta blockers is essential for patients who are newly diagnosed with hyperthyroidism.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.8698" target="_blank">https://dx.doi.org/10.1002/ccr3.8698</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_861e5695793e07d4c10488656c8a307c |
| identifier_str_mv | 10.1002/ccr3.8698 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29714984 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case reportMohamed Kamal Sabra (17075230)Anwar Joudeh (12234713)Mahmoud Al Niserat (21841439)Riyadh Hammamy (14777230)Biomedical and clinical sciencesCardiovascular medicine and haematologyMedical biochemistry and metabolomicscardiomyopathyGrave's diseasejaundicepancytopenia<h3>Key Clinical Message</h3><p dir="ltr">Graves's disease must be treated promptly to avoid serious sequelae such as cardiomyopathy, liver injury, and pancytopenia. Early initiation of antithyroid medications and beta blockers could not be overrated even in the presence of these complications.</p><p dir="ltr">Graves' disease causes a large spectrum of clinical manifestations. Delayed diagnosis and management of Graves' disease could lead to serious systemic sequelae. We describe a case of a young man who presented with progressive cough, increased abdominal girth and ankle swelling for a few months. On examination, he had jaundice, bilateral exophthalmos, diffuse goiter, ascites, and significant lower limb edema. Laboratory investigations showed increased Thyroxin level with a suppressed thyroid stimulating hormone and positive anti‐thyrotropin receptor antibodies. Also, the patient had pancytopenia, coagulopathy and cholestatic pattern of elevated liver enzymes. Echocardiography demonstrated mildly reduced left ventricular function with diastolic dysfunction, but electrocardiogram did not show atrial fibrillation. Despite the concerns about using antithyroid medications in patients with impaired liver function tests and pancytopenia, the patient improved dramatically without worsening of his hematological or biochemical parameters. Early initiation of antithyroid medications and beta blockers is essential for patients who are newly diagnosed with hyperthyroidism.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.8698" target="_blank">https://dx.doi.org/10.1002/ccr3.8698</a></p>2024-04-24T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/ccr3.8698https://figshare.com/articles/journal_contribution/A_young_patient_with_Graves_disease_presenting_with_a_triad_of_heart_failure_pancytopenia_and_jaundice_A_case_report/29714984CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297149842024-04-24T09:00:00Z |
| spellingShingle | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report Mohamed Kamal Sabra (17075230) Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics cardiomyopathy Grave's disease jaundice pancytopenia |
| status_str | publishedVersion |
| title | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report |
| title_full | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report |
| title_fullStr | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report |
| title_full_unstemmed | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report |
| title_short | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report |
| title_sort | A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics cardiomyopathy Grave's disease jaundice pancytopenia |