Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology
<div><p>We aimed to develop a conceptual framework of diabetes mellitus (DM) effects on tuberculosis (TB) natural history and treatment outcomes, and to assess the impact of these effects on TB-transmission dynamics. The model was calibrated using TB data for India. A conceptual framewor...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2019
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513513954738176 |
|---|---|
| author | Susanne F. Awad (11607966) |
| author2 | Soha R. Dargham (3613250) Ryosuke Omori (114776) Fiona Pearson (4607545) Julia A. Critchley (11619720) Laith J. Abu-Raddad (9262524) |
| author2_role | author author author author author |
| author_facet | Susanne F. Awad (11607966) Soha R. Dargham (3613250) Ryosuke Omori (114776) Fiona Pearson (4607545) Julia A. Critchley (11619720) Laith J. Abu-Raddad (9262524) |
| author_role | author |
| dc.creator.none.fl_str_mv | Susanne F. Awad (11607966) Soha R. Dargham (3613250) Ryosuke Omori (114776) Fiona Pearson (4607545) Julia A. Critchley (11619720) Laith J. Abu-Raddad (9262524) |
| dc.date.none.fl_str_mv | 2019-06-11T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41598-019-44916-7 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Analytical_Exploration_of_Potential_Pathways_by_which_Diabetes_Mellitus_Impacts_Tuberculosis_Epidemiology/25907566 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Tuberculosis Natural History Treatment Outcomes TB-Transmission Dynamics Conceptual Framework Mathematical Model Diabetes Mellitus |
| dc.title.none.fl_str_mv | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>We aimed to develop a conceptual framework of diabetes mellitus (DM) effects on tuberculosis (TB) natural history and treatment outcomes, and to assess the impact of these effects on TB-transmission dynamics. The model was calibrated using TB data for India. A conceptual framework was developed based on a literature review, and then translated into a mathematical model to assess the impact of the DM-on-TB effects. The impact was analyzed using TB-disease incidence hazard ratio (HR) and population attributable fraction (PAF) measures. Evidence was identified for 10 plausible DM-on-TB effects. Assuming a flat change of 300% (meaning an effect size of 3.0) for each DM-on-TB effect, the HR ranged between 1.0 (Effect 9-Recovery) and 2.7 (Effect 2-Fast progression); most effects did not have an impact on the HR. Meanwhile, TB-disease incidence attributed directly and indirectly to each effect ranged between −4.6% (Effect 7-TB mortality) and 34.5% (Effect 2-Fast progression). The second largest impact was for Effect 6-Disease infectiousness at 29.9%. In conclusion, DM can affect TB-transmission dynamics in multiple ways, most of which are poorly characterized and difficult to assess in epidemiologic studies. The indirect (e.g. onward transmission) impacts of some DM-on-TB effects are comparable in scale to the direct impacts. While the impact of several effects on the HR was limited, the impact on the PAF was substantial suggesting that DM could be impacting TB epidemiology to a larger extent than previously thought.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-019-44916-7" target="_blank">https://dx.doi.org/10.1038/s41598-019-44916-7</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8638998e89a77f7e5931fd9e14229478 |
| identifier_str_mv | 10.1038/s41598-019-44916-7 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25907566 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis EpidemiologySusanne F. Awad (11607966)Soha R. Dargham (3613250)Ryosuke Omori (114776)Fiona Pearson (4607545)Julia A. Critchley (11619720)Laith J. Abu-Raddad (9262524)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologyTuberculosisNatural HistoryTreatment OutcomesTB-Transmission DynamicsConceptual FrameworkMathematical ModelDiabetes Mellitus<div><p>We aimed to develop a conceptual framework of diabetes mellitus (DM) effects on tuberculosis (TB) natural history and treatment outcomes, and to assess the impact of these effects on TB-transmission dynamics. The model was calibrated using TB data for India. A conceptual framework was developed based on a literature review, and then translated into a mathematical model to assess the impact of the DM-on-TB effects. The impact was analyzed using TB-disease incidence hazard ratio (HR) and population attributable fraction (PAF) measures. Evidence was identified for 10 plausible DM-on-TB effects. Assuming a flat change of 300% (meaning an effect size of 3.0) for each DM-on-TB effect, the HR ranged between 1.0 (Effect 9-Recovery) and 2.7 (Effect 2-Fast progression); most effects did not have an impact on the HR. Meanwhile, TB-disease incidence attributed directly and indirectly to each effect ranged between −4.6% (Effect 7-TB mortality) and 34.5% (Effect 2-Fast progression). The second largest impact was for Effect 6-Disease infectiousness at 29.9%. In conclusion, DM can affect TB-transmission dynamics in multiple ways, most of which are poorly characterized and difficult to assess in epidemiologic studies. The indirect (e.g. onward transmission) impacts of some DM-on-TB effects are comparable in scale to the direct impacts. While the impact of several effects on the HR was limited, the impact on the PAF was substantial suggesting that DM could be impacting TB epidemiology to a larger extent than previously thought.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41598-019-44916-7" target="_blank">https://dx.doi.org/10.1038/s41598-019-44916-7</a></p>2019-06-11T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41598-019-44916-7https://figshare.com/articles/journal_contribution/Analytical_Exploration_of_Potential_Pathways_by_which_Diabetes_Mellitus_Impacts_Tuberculosis_Epidemiology/25907566CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259075662019-06-11T03:00:00Z |
| spellingShingle | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology Susanne F. Awad (11607966) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Tuberculosis Natural History Treatment Outcomes TB-Transmission Dynamics Conceptual Framework Mathematical Model Diabetes Mellitus |
| status_str | publishedVersion |
| title | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology |
| title_full | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology |
| title_fullStr | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology |
| title_full_unstemmed | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology |
| title_short | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology |
| title_sort | Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Tuberculosis Natural History Treatment Outcomes TB-Transmission Dynamics Conceptual Framework Mathematical Model Diabetes Mellitus |