Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro
<p dir="ltr">Diabetes mellitus is a chronic disease affecting over 500 million adults globally and is mainly categorized as type 1 diabetes mellitus (T1DM), where pancreatic beta cells are destroyed, and type 2 diabetes mellitus (T2DM), characterized by beta cell dysfunction. This re...
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| مؤلفون آخرون: | , , |
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2023
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| _version_ | 1864513509176377344 |
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| author | Razik Bin Abdul Mu-u-min (15430008) |
| author2 | Abdoulaye Diane (14152749) Asma Allouch (15430010) Heba H. Al-Siddiqi (17733783) |
| author2_role | author author author |
| author_facet | Razik Bin Abdul Mu-u-min (15430008) Abdoulaye Diane (14152749) Asma Allouch (15430010) Heba H. Al-Siddiqi (17733783) |
| author_role | author |
| dc.creator.none.fl_str_mv | Razik Bin Abdul Mu-u-min (15430008) Abdoulaye Diane (14152749) Asma Allouch (15430010) Heba H. Al-Siddiqi (17733783) |
| dc.date.none.fl_str_mv | 2023-05-29T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/biomedicines11061577 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Ca_sup_2_sup_sup_sup_-Mediated_Signaling_Pathways_A_Promising_Target_for_the_Successful_Generation_of_Mature_and_Functional_Stem_Cell-Derived_Pancreatic_Beta_Cells_In_Vitro/26535511 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences beta cells calcium signaling diabetes stem cells differentiation |
| dc.title.none.fl_str_mv | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Diabetes mellitus is a chronic disease affecting over 500 million adults globally and is mainly categorized as type 1 diabetes mellitus (T1DM), where pancreatic beta cells are destroyed, and type 2 diabetes mellitus (T2DM), characterized by beta cell dysfunction. This review highlights the importance of the divalent cation calcium (Ca<sup>2+</sup>) and its associated signaling pathways in the proper functioning of beta cells and underlines the effects of Ca<sup>2+</sup> dysfunction on beta cell function and its implications for the onset of diabetes. Great interest and promise are held by human pluripotent stem cell (hPSC) technology to generate functional pancreatic beta cells from diabetic patient-derived stem cells to replace the dysfunctional cells, thereby compensating for insulin deficiency and reducing the comorbidities of the disease and its associated financial and social burden on the patient and society. Beta-like cells generated by most current differentiation protocols have blunted functionality compared to their adult human counterparts. The Ca<sup>2+</sup> dynamics in stem cell-derived beta-like cells and adult beta cells are summarized in this review, revealing the importance of proper Ca<sup>2+</sup> homeostasis in beta-cell function. Consequently, the importance of targeting Ca<sup>2+</sup> function in differentiation protocols is suggested to improve current strategies to use hPSCs to generate mature and functional beta-like cells with a comparable glucose-stimulated insulin secretion (GSIS) profile to adult beta cells.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicines<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/biomedicines11061577" target="_blank">https://dx.doi.org/10.3390/biomedicines11061577</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_864fe5125f32ca7baebdebad4d50c424 |
| identifier_str_mv | 10.3390/biomedicines11061577 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26535511 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In VitroRazik Bin Abdul Mu-u-min (15430008)Abdoulaye Diane (14152749)Asma Allouch (15430010)Heba H. Al-Siddiqi (17733783)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsPharmacology and pharmaceutical sciencesbeta cellscalcium signalingdiabetesstem cellsdifferentiation<p dir="ltr">Diabetes mellitus is a chronic disease affecting over 500 million adults globally and is mainly categorized as type 1 diabetes mellitus (T1DM), where pancreatic beta cells are destroyed, and type 2 diabetes mellitus (T2DM), characterized by beta cell dysfunction. This review highlights the importance of the divalent cation calcium (Ca<sup>2+</sup>) and its associated signaling pathways in the proper functioning of beta cells and underlines the effects of Ca<sup>2+</sup> dysfunction on beta cell function and its implications for the onset of diabetes. Great interest and promise are held by human pluripotent stem cell (hPSC) technology to generate functional pancreatic beta cells from diabetic patient-derived stem cells to replace the dysfunctional cells, thereby compensating for insulin deficiency and reducing the comorbidities of the disease and its associated financial and social burden on the patient and society. Beta-like cells generated by most current differentiation protocols have blunted functionality compared to their adult human counterparts. The Ca<sup>2+</sup> dynamics in stem cell-derived beta-like cells and adult beta cells are summarized in this review, revealing the importance of proper Ca<sup>2+</sup> homeostasis in beta-cell function. Consequently, the importance of targeting Ca<sup>2+</sup> function in differentiation protocols is suggested to improve current strategies to use hPSCs to generate mature and functional beta-like cells with a comparable glucose-stimulated insulin secretion (GSIS) profile to adult beta cells.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicines<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/biomedicines11061577" target="_blank">https://dx.doi.org/10.3390/biomedicines11061577</a></p>2023-05-29T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/biomedicines11061577https://figshare.com/articles/journal_contribution/Ca_sup_2_sup_sup_sup_-Mediated_Signaling_Pathways_A_Promising_Target_for_the_Successful_Generation_of_Mature_and_Functional_Stem_Cell-Derived_Pancreatic_Beta_Cells_In_Vitro/26535511CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/265355112023-05-29T09:00:00Z |
| spellingShingle | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro Razik Bin Abdul Mu-u-min (15430008) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences beta cells calcium signaling diabetes stem cells differentiation |
| status_str | publishedVersion |
| title | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro |
| title_full | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro |
| title_fullStr | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro |
| title_full_unstemmed | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro |
| title_short | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro |
| title_sort | Ca<sup>2</sup><sup>+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences beta cells calcium signaling diabetes stem cells differentiation |