Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens
<p dir="ltr">Ochratoxin A (OTA), an important fungal metabolite in foods and feeds has been shown to induce oxidative stress and cellular injuries to human and animal subjects. This study was designed to investigate the mode of action of a biological modifier Trichosporon mycotoxiniv...
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2021
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| _version_ | 1864513547803820032 |
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| author | Sheraz Ahmed Bhatti (9759633) |
| author2 | Muhammad Zargham Khan (9759636) Muhammad Kashif Saleemi (9759639) Zahoor Ul Hassan (9759642) |
| author2_role | author author author |
| author_facet | Sheraz Ahmed Bhatti (9759633) Muhammad Zargham Khan (9759636) Muhammad Kashif Saleemi (9759639) Zahoor Ul Hassan (9759642) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sheraz Ahmed Bhatti (9759633) Muhammad Zargham Khan (9759636) Muhammad Kashif Saleemi (9759639) Zahoor Ul Hassan (9759642) |
| dc.date.none.fl_str_mv | 2021-09-25T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cbi.2021.109614 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Dietary_Trichosporon_mycotoxinivoron_modulates_ochratoxin-A_induced_altered_performance_hepatic_and_renal_antioxidant_capacity_and_tissue_injury_in_broiler_chickens/24420469 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Agricultural, veterinary and food sciences Veterinary sciences Biological sciences Biochemistry and cell biology Zoology Ochratoxin A Oxidative stress Trichosporon mycotoxinivorans Biological modifier Broiler chickens |
| dc.title.none.fl_str_mv | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Ochratoxin A (OTA), an important fungal metabolite in foods and feeds has been shown to induce oxidative stress and cellular injuries to human and animal subjects. This study was designed to investigate the mode of action of a biological modifier Trichosporon mycotoxinivorans (TM), against OTA-mediated oxidative stress and tissue toxicity on broiler chickens. The birds were offered diets supplemented with OTA (0.15 and 0.3 mg/kg feed) and/or TM (0.5, 1.0 g/kg) for 42 days of age, and blood and tissue samples were collected to examine the oxidative stress, biochemical and histopathological parameters. Dietary OTA at all the tested levels induced the hepatic and renal tissue injury as indicated by significant decreased total antioxidant capacity in these organs along with significant decreased (p ≤ 0.05) serum concentrations of total proteins and albumin. The serum concentrations of alanine aminotransferase (ALT) and urea were significantly increased, and these observations were further supported by degenerative changes and increased relative weights of liver and kidneys. The dietary supplementation of TM at both tested levels relieved the detrimental impact of 0.15 and 0.3 mg OTA/kg on the studied parameters. The results of the study demonstrated that dietary TM significantly protects broiler chickens by reducing OTA-induced oxidative damage and tissue injury.</p><h2>Other Information</h2><p dir="ltr">Published in: Chemico-Biological Interactions<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cbi.2021.109614" target="_blank">https://dx.doi.org/10.1016/j.cbi.2021.109614</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8776f7c4c2599f52f90f7bcc06209a76 |
| identifier_str_mv | 10.1016/j.cbi.2021.109614 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24420469 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickensSheraz Ahmed Bhatti (9759633)Muhammad Zargham Khan (9759636)Muhammad Kashif Saleemi (9759639)Zahoor Ul Hassan (9759642)Agricultural, veterinary and food sciencesVeterinary sciencesBiological sciencesBiochemistry and cell biologyZoologyOchratoxin AOxidative stressTrichosporon mycotoxinivoransBiological modifierBroiler chickens<p dir="ltr">Ochratoxin A (OTA), an important fungal metabolite in foods and feeds has been shown to induce oxidative stress and cellular injuries to human and animal subjects. This study was designed to investigate the mode of action of a biological modifier Trichosporon mycotoxinivorans (TM), against OTA-mediated oxidative stress and tissue toxicity on broiler chickens. The birds were offered diets supplemented with OTA (0.15 and 0.3 mg/kg feed) and/or TM (0.5, 1.0 g/kg) for 42 days of age, and blood and tissue samples were collected to examine the oxidative stress, biochemical and histopathological parameters. Dietary OTA at all the tested levels induced the hepatic and renal tissue injury as indicated by significant decreased total antioxidant capacity in these organs along with significant decreased (p ≤ 0.05) serum concentrations of total proteins and albumin. The serum concentrations of alanine aminotransferase (ALT) and urea were significantly increased, and these observations were further supported by degenerative changes and increased relative weights of liver and kidneys. The dietary supplementation of TM at both tested levels relieved the detrimental impact of 0.15 and 0.3 mg OTA/kg on the studied parameters. The results of the study demonstrated that dietary TM significantly protects broiler chickens by reducing OTA-induced oxidative damage and tissue injury.</p><h2>Other Information</h2><p dir="ltr">Published in: Chemico-Biological Interactions<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cbi.2021.109614" target="_blank">https://dx.doi.org/10.1016/j.cbi.2021.109614</a></p>2021-09-25T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cbi.2021.109614https://figshare.com/articles/journal_contribution/Dietary_Trichosporon_mycotoxinivoron_modulates_ochratoxin-A_induced_altered_performance_hepatic_and_renal_antioxidant_capacity_and_tissue_injury_in_broiler_chickens/24420469CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244204692021-09-25T00:00:00Z |
| spellingShingle | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens Sheraz Ahmed Bhatti (9759633) Agricultural, veterinary and food sciences Veterinary sciences Biological sciences Biochemistry and cell biology Zoology Ochratoxin A Oxidative stress Trichosporon mycotoxinivorans Biological modifier Broiler chickens |
| status_str | publishedVersion |
| title | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens |
| title_full | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens |
| title_fullStr | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens |
| title_full_unstemmed | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens |
| title_short | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens |
| title_sort | Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens |
| topic | Agricultural, veterinary and food sciences Veterinary sciences Biological sciences Biochemistry and cell biology Zoology Ochratoxin A Oxidative stress Trichosporon mycotoxinivorans Biological modifier Broiler chickens |