On collagen fiber morphoelasticity and homeostatic remodeling tone
<p dir="ltr">A variety of <u>biochemical</u> and physical processes participate in the creation and maintenance of collagen in biological tissue. Under mechanical stimuli these collagen fibers undergo continuous processes of morphoelastic change. The model presented here...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2021
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| الملخص: | <p dir="ltr">A variety of <u>biochemical</u> and physical processes participate in the creation and maintenance of collagen in biological tissue. Under mechanical stimuli these collagen fibers undergo continuous processes of morphoelastic change. The model presented here is motivated by experimental reports of stretch-stabilization of the collagen fibers to <u>enzymatic degradation</u>. The fiber structure is modeled in terms of a <u>fiber density</u> evolution that is regulated by means of a fixed creation rate and a mechano-sensitive <u>dissolution rate</u>. The theory accounts for the possibly different <u>natural configurations </u>of the fiber unit constituents and the <u>ground substance </u>matrix. It also generalizes previous theoretical descriptions so as to account for finite <u>survival times </u>of the individual fiber units. Special consideration is given to <u>steady state</u> fiber-remodeling processes in which fiber creation and dissolution are in balance. Fiber assembly processes that involve prestretching the fiber constituents yield a homeostatic stress response with a characteristic fiber tone. Fiber density returns to <u>homeostasis</u> after mechanical disruption when sufficient time has passed.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Journal of the Mechanical Behavior of Biomedical Materials<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jmbbm.2020.104154" target="_blank">https://dx.doi.org/10.1016/j.jmbbm.2020.104154</a></p> |
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