Degradation of hydroxychloroquine by electrochemical advanced oxidation processes
<p dir="ltr">In this work, the degradation of hydroxychloroquine (HCQ) drug in aqueous solution by electrochemical advanced oxidation processes including electrochemical oxidation (EO) using boron doped diamond (BDD) and its combination with UV irradiation (photo-assisted electrochem...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| منشور في: |
2020
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513555024314368 |
|---|---|
| author | Nasr Bensalah (14778253) |
| author2 | Sondos Midassi (17115616) Mohammad I. Ahmad (17115619) Ahmed Bedoui (16488921) |
| author2_role | author author author |
| author_facet | Nasr Bensalah (14778253) Sondos Midassi (17115616) Mohammad I. Ahmad (17115619) Ahmed Bedoui (16488921) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nasr Bensalah (14778253) Sondos Midassi (17115616) Mohammad I. Ahmad (17115619) Ahmed Bedoui (16488921) |
| dc.date.none.fl_str_mv | 2020-12-15T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cej.2020.126279 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Degradation_of_hydroxychloroquine_by_electrochemical_advanced_oxidation_processes/24270328 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Chemical engineering Hydroxychloroquine Electrochemical oxidation Boron doped diamond Hydroxyl radicals UV irradiation Specific energy consumption Central Laboratories Unit (QU) |
| dc.title.none.fl_str_mv | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In this work, the degradation of hydroxychloroquine (HCQ) drug in aqueous solution by electrochemical advanced oxidation processes including electrochemical oxidation (EO) using boron doped diamond (BDD) and its combination with UV irradiation (photo-assisted electrochemical oxidation, PEO) and sonication (sono-assisted electrochemical oxidation, SEO) was investigated. EO using BDD anode achieved the complete depletion of HCQ from aqueous solutions in regardless of HCQ concentration, current density, and initial pH value. The decay of HCQ was more rapid than total organic carbon (TOC) indicating that the degradation of HCQ by EO using BDD anode involves successive steps leading to the formation of organic intermediates that end to mineralize. Furthermore, the results demonstrated the release chloride (Cl<sup>−</sup>) ions at the first stages of HCQ degradation. In addition, the organic nitrogen was converted mainly into NO<sub>3</sub><sup>−</sup> and NH<sub>4</sub><sup>+</sup> and small amounts of volatile nitrogen species (NH<sub>3</sub> and NO<sub>x</sub>). Chromatography analysis confirmed the formation of 7-chloro-4-quinolinamine (CQLA), oxamic and oxalic acids as intermediates of HCQ degradation by EO using BDD anode. The combination of EO with UV irradiation or sonication enhances the kinetics and the efficacy of HCQ oxidation. PEO requires the lowest energy consumption (EC) of 63 kWh/m<sup>3</sup> showing its cost-effectiveness. PEO has the potential to be an excellent alternative method for the treatment of wastewaters contaminated with HCQ drug and its derivatives.</p><h2>Other Information</h2><p dir="ltr">Published in: Chemical Engineering Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cej.2020.126279" target="_blank">https://dx.doi.org/10.1016/j.cej.2020.126279</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_8799bf5906e94fe3c45c5c6deff00341 |
| identifier_str_mv | 10.1016/j.cej.2020.126279 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24270328 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Degradation of hydroxychloroquine by electrochemical advanced oxidation processesNasr Bensalah (14778253)Sondos Midassi (17115616)Mohammad I. Ahmad (17115619)Ahmed Bedoui (16488921)EngineeringChemical engineeringHydroxychloroquineElectrochemical oxidationBoron doped diamondHydroxyl radicalsUV irradiationSpecific energy consumptionCentral Laboratories Unit (QU)<p dir="ltr">In this work, the degradation of hydroxychloroquine (HCQ) drug in aqueous solution by electrochemical advanced oxidation processes including electrochemical oxidation (EO) using boron doped diamond (BDD) and its combination with UV irradiation (photo-assisted electrochemical oxidation, PEO) and sonication (sono-assisted electrochemical oxidation, SEO) was investigated. EO using BDD anode achieved the complete depletion of HCQ from aqueous solutions in regardless of HCQ concentration, current density, and initial pH value. The decay of HCQ was more rapid than total organic carbon (TOC) indicating that the degradation of HCQ by EO using BDD anode involves successive steps leading to the formation of organic intermediates that end to mineralize. Furthermore, the results demonstrated the release chloride (Cl<sup>−</sup>) ions at the first stages of HCQ degradation. In addition, the organic nitrogen was converted mainly into NO<sub>3</sub><sup>−</sup> and NH<sub>4</sub><sup>+</sup> and small amounts of volatile nitrogen species (NH<sub>3</sub> and NO<sub>x</sub>). Chromatography analysis confirmed the formation of 7-chloro-4-quinolinamine (CQLA), oxamic and oxalic acids as intermediates of HCQ degradation by EO using BDD anode. The combination of EO with UV irradiation or sonication enhances the kinetics and the efficacy of HCQ oxidation. PEO requires the lowest energy consumption (EC) of 63 kWh/m<sup>3</sup> showing its cost-effectiveness. PEO has the potential to be an excellent alternative method for the treatment of wastewaters contaminated with HCQ drug and its derivatives.</p><h2>Other Information</h2><p dir="ltr">Published in: Chemical Engineering Journal<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cej.2020.126279" target="_blank">https://dx.doi.org/10.1016/j.cej.2020.126279</a></p>2020-12-15T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cej.2020.126279https://figshare.com/articles/journal_contribution/Degradation_of_hydroxychloroquine_by_electrochemical_advanced_oxidation_processes/24270328CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242703282020-12-15T00:00:00Z |
| spellingShingle | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes Nasr Bensalah (14778253) Engineering Chemical engineering Hydroxychloroquine Electrochemical oxidation Boron doped diamond Hydroxyl radicals UV irradiation Specific energy consumption Central Laboratories Unit (QU) |
| status_str | publishedVersion |
| title | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes |
| title_full | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes |
| title_fullStr | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes |
| title_full_unstemmed | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes |
| title_short | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes |
| title_sort | Degradation of hydroxychloroquine by electrochemical advanced oxidation processes |
| topic | Engineering Chemical engineering Hydroxychloroquine Electrochemical oxidation Boron doped diamond Hydroxyl radicals UV irradiation Specific energy consumption Central Laboratories Unit (QU) |