Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System
<p>Mesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy. MSCs, initially obtained from bone marrow, can be derived from several...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2019
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| _version_ | 1864513563251441664 |
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| author | Bella S. Guerrouahen (14153289) |
| author2 | Heba Sidahmed (2632471) Asma Al Sulaiti (14590691) Moza Al Khulaifi (14166135) Chiara Cugno (3441302) |
| author2_role | author author author author |
| author_facet | Bella S. Guerrouahen (14153289) Heba Sidahmed (2632471) Asma Al Sulaiti (14590691) Moza Al Khulaifi (14166135) Chiara Cugno (3441302) |
| author_role | author |
| dc.creator.none.fl_str_mv | Bella S. Guerrouahen (14153289) Heba Sidahmed (2632471) Asma Al Sulaiti (14590691) Moza Al Khulaifi (14166135) Chiara Cugno (3441302) |
| dc.date.none.fl_str_mv | 2019-08-05T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2019/7219297 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Enhancing_Mesenchymal_Stromal_Cell_Immunomodulation_for_Treating_Conditions_Influenced_by_the_Immune_System/22058840 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Immunology Medical biotechnology Cell Biology Molecular Biology |
| dc.title.none.fl_str_mv | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Mesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy. MSCs, initially obtained from bone marrow, can be derived from several other tissues, such as adipose tissue, placenta, and umbilical cord. Diversity in tissue sourcing and manufacturing procedures has significant effects on MSC products. However, in 2006, a minimal set of standard criteria has been issued by the International Society of Cellular Therapy for defining derived MSCs. These include adherence to plastic in conventional culture conditions, particular phenotype, and multilineage differentiation capacity <em>in vitro</em>. Moreover, MSCs have trophic capabilities, a high <em>in vitro</em> self-renewal ability, and immunomodulatory characteristics. Thus, immunosuppressive treatment with MSCs has been proposed as a potential therapeutic alternative for conditions in which the immune system cells influence outcomes, such as inflammatory and autoimmune diseases. The precise mechanism by which MSCs affect functions of most immune effector cells is not completely understood but involves direct contact with immune cells, soluble mediators, and local microenvironmental factors. Recently, it has been shown that their homeostatic resting state requires activation, which can be achieved <em>in vitro</em> with various cytokines, including interferon-<em>γ</em>. In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of <em>in vitro</em> preconditioning and its use in preclinical studies. We discuss the clinical aspects of using MSCs as an immunomodulatory treatment. Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development. </p> <h2>Other information</h2> <p>Published in: Stem Cells International<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2019/7219297" target="_blank">http://dx.doi.org/10.1155/2019/7219297</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_886bd39f10ab86a2f180905ae5b5da3f |
| identifier_str_mv | 10.1155/2019/7219297 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22058840 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune SystemBella S. Guerrouahen (14153289)Heba Sidahmed (2632471)Asma Al Sulaiti (14590691)Moza Al Khulaifi (14166135)Chiara Cugno (3441302)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesClinical sciencesImmunologyMedical biotechnologyCell BiologyMolecular Biology<p>Mesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy. MSCs, initially obtained from bone marrow, can be derived from several other tissues, such as adipose tissue, placenta, and umbilical cord. Diversity in tissue sourcing and manufacturing procedures has significant effects on MSC products. However, in 2006, a minimal set of standard criteria has been issued by the International Society of Cellular Therapy for defining derived MSCs. These include adherence to plastic in conventional culture conditions, particular phenotype, and multilineage differentiation capacity <em>in vitro</em>. Moreover, MSCs have trophic capabilities, a high <em>in vitro</em> self-renewal ability, and immunomodulatory characteristics. Thus, immunosuppressive treatment with MSCs has been proposed as a potential therapeutic alternative for conditions in which the immune system cells influence outcomes, such as inflammatory and autoimmune diseases. The precise mechanism by which MSCs affect functions of most immune effector cells is not completely understood but involves direct contact with immune cells, soluble mediators, and local microenvironmental factors. Recently, it has been shown that their homeostatic resting state requires activation, which can be achieved <em>in vitro</em> with various cytokines, including interferon-<em>γ</em>. In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of <em>in vitro</em> preconditioning and its use in preclinical studies. We discuss the clinical aspects of using MSCs as an immunomodulatory treatment. Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development. </p> <h2>Other information</h2> <p>Published in: Stem Cells International<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2019/7219297" target="_blank">http://dx.doi.org/10.1155/2019/7219297</a></p>2019-08-05T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2019/7219297https://figshare.com/articles/journal_contribution/Enhancing_Mesenchymal_Stromal_Cell_Immunomodulation_for_Treating_Conditions_Influenced_by_the_Immune_System/22058840CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/220588402019-08-05T06:00:00Z |
| spellingShingle | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System Bella S. Guerrouahen (14153289) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Immunology Medical biotechnology Cell Biology Molecular Biology |
| status_str | publishedVersion |
| title | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_full | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_fullStr | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_full_unstemmed | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_short | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_sort | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Immunology Medical biotechnology Cell Biology Molecular Biology |