A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours
<h3>Introduction</h3><p dir="ltr">Insulin‐like growth factor‐2 (IGF‐2)‐mediated hypoglycemia is a rare yet clinically significant entity with considerable morbidity and mortality. Existing literature is limited and fails to offer a comprehensive understanding of its clini...
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2024
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| author | Fateen Ata (12217764) |
| author2 | Hassan Choudry (12217767) Adeel Ahmad Khan (14152953) Anum (21633488) Ibrahim Khamees (14153301) Anas Al‐sadi (17746794) Abdelaziz Mohamed (14777668) Lujain Malkawi (15468194) Esra'a Aljaloudi (21633491) |
| author2_role | author author author author author author author author |
| author_facet | Fateen Ata (12217764) Hassan Choudry (12217767) Adeel Ahmad Khan (14152953) Anum (21633488) Ibrahim Khamees (14153301) Anas Al‐sadi (17746794) Abdelaziz Mohamed (14777668) Lujain Malkawi (15468194) Esra'a Aljaloudi (21633491) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fateen Ata (12217764) Hassan Choudry (12217767) Adeel Ahmad Khan (14152953) Anum (21633488) Ibrahim Khamees (14153301) Anas Al‐sadi (17746794) Abdelaziz Mohamed (14777668) Lujain Malkawi (15468194) Esra'a Aljaloudi (21633491) |
| dc.date.none.fl_str_mv | 2024-02-27T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/edm2.471 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_systematic_review_of_literature_on_Insulin_like_growth_factor_2_mediated_hypoglycaemia_in_non_islet_cell_tumours/29446028 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis hypoglycaemia IGF 2 IGF II insulin-like growth factor-2 NICTH non-insulin mediated hypoglycaemia non-islet cell tumour hypoglycaemia |
| dc.title.none.fl_str_mv | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Insulin‐like growth factor‐2 (IGF‐2)‐mediated hypoglycemia is a rare yet clinically significant entity with considerable morbidity and mortality. Existing literature is limited and fails to offer a comprehensive understanding of its clinical trajectory, management and prognostication.</p><h3>Methods</h3><p dir="ltr">Systematic review of English‐language articles reporting primary patient data on IMH was searched using electronic databases (PubMed, Scopus and Embase) from any date up to 21 December 2022. Data were analysed in STATA‐16.</p><h3>Results</h3><p dir="ltr">The systematic review contains 172 studies, including 1 Randomised controlled trial, 1 prospective observational study, 5 retrospective observational studies, 150 case reports, 11 case series and 4 conference abstracts. A total of 233 patients were analysed, averaging 60.6 ± 17.1 years in age, with comparable proportions of males and females. The commonest tumours associated with Insulin‐like Growth Factor‐2‐mediated hypoglycaemia were fibrous tumours (<i>N</i> = 124, 53.2%), followed by non‐fibrous tumours originating from the liver (<i>N</i> = 21, 9%), hemangiopericytomas (<i>N</i> = 20, 8.5%) and mesotheliomas (<i>N</i> = 11, 4.7%). Hypoglycaemia was the presenting feature of NICT in 42% of cases. Predominant clinical features included loss of consciousness (26.7%) and confusion (21%). The mean IGF‐2 and IGF‐1 levels were 882.3 ± 630.6 ng/dL and 41.8 ± 47.8, respectively, with no significant correlation between these levels and patient outcomes. Surgical removal was the most employed treatment modality (47.2%), followed by medication therapy. The recovery rate was 77%, with chronic liver disease (CLD) significantly associated with a poor outcome (OR: 7.23, P: 0.03). Tumours originating from fibrous tissues were significantly associated with recovery (<i>p</i> < .001). In the logistic regression model, CLD remained a significant predictor of poor outcomes.</p><h3>Conclusion</h3><p dir="ltr">This systematic review highlights that most non‐islet‐cell tumour‐hypoglycaemia (NICTH) is due to fibrous tumours. NICTs demonstrate a variable prognosis, which is fair if originating from fibrous tissue. Management such as octreotide, corticosteroids, diazoxide, embolization, radiotherapy and surgical resection have disparate success rates.</p><h2>Other Information</h2><p dir="ltr">Published in: Endocrinology, Diabetes & Metabolism<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/edm2.471" target="_blank">https://dx.doi.org/10.1002/edm2.471</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_88793f025da84d09bed28d9437fb5537 |
| identifier_str_mv | 10.1002/edm2.471 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29446028 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumoursFateen Ata (12217764)Hassan Choudry (12217767)Adeel Ahmad Khan (14152953)Anum (21633488)Ibrahim Khamees (14153301)Anas Al‐sadi (17746794)Abdelaziz Mohamed (14777668)Lujain Malkawi (15468194)Esra'a Aljaloudi (21633491)Biomedical and clinical sciencesMedical biochemistry and metabolomicsOncology and carcinogenesishypoglycaemiaIGF 2IGF IIinsulin-like growth factor-2NICTHnon-insulin mediated hypoglycaemianon-islet cell tumour hypoglycaemia<h3>Introduction</h3><p dir="ltr">Insulin‐like growth factor‐2 (IGF‐2)‐mediated hypoglycemia is a rare yet clinically significant entity with considerable morbidity and mortality. Existing literature is limited and fails to offer a comprehensive understanding of its clinical trajectory, management and prognostication.</p><h3>Methods</h3><p dir="ltr">Systematic review of English‐language articles reporting primary patient data on IMH was searched using electronic databases (PubMed, Scopus and Embase) from any date up to 21 December 2022. Data were analysed in STATA‐16.</p><h3>Results</h3><p dir="ltr">The systematic review contains 172 studies, including 1 Randomised controlled trial, 1 prospective observational study, 5 retrospective observational studies, 150 case reports, 11 case series and 4 conference abstracts. A total of 233 patients were analysed, averaging 60.6 ± 17.1 years in age, with comparable proportions of males and females. The commonest tumours associated with Insulin‐like Growth Factor‐2‐mediated hypoglycaemia were fibrous tumours (<i>N</i> = 124, 53.2%), followed by non‐fibrous tumours originating from the liver (<i>N</i> = 21, 9%), hemangiopericytomas (<i>N</i> = 20, 8.5%) and mesotheliomas (<i>N</i> = 11, 4.7%). Hypoglycaemia was the presenting feature of NICT in 42% of cases. Predominant clinical features included loss of consciousness (26.7%) and confusion (21%). The mean IGF‐2 and IGF‐1 levels were 882.3 ± 630.6 ng/dL and 41.8 ± 47.8, respectively, with no significant correlation between these levels and patient outcomes. Surgical removal was the most employed treatment modality (47.2%), followed by medication therapy. The recovery rate was 77%, with chronic liver disease (CLD) significantly associated with a poor outcome (OR: 7.23, P: 0.03). Tumours originating from fibrous tissues were significantly associated with recovery (<i>p</i> < .001). In the logistic regression model, CLD remained a significant predictor of poor outcomes.</p><h3>Conclusion</h3><p dir="ltr">This systematic review highlights that most non‐islet‐cell tumour‐hypoglycaemia (NICTH) is due to fibrous tumours. NICTs demonstrate a variable prognosis, which is fair if originating from fibrous tissue. Management such as octreotide, corticosteroids, diazoxide, embolization, radiotherapy and surgical resection have disparate success rates.</p><h2>Other Information</h2><p dir="ltr">Published in: Endocrinology, Diabetes & Metabolism<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/edm2.471" target="_blank">https://dx.doi.org/10.1002/edm2.471</a></p>2024-02-27T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/edm2.471https://figshare.com/articles/journal_contribution/A_systematic_review_of_literature_on_Insulin_like_growth_factor_2_mediated_hypoglycaemia_in_non_islet_cell_tumours/29446028CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294460282024-02-27T09:00:00Z |
| spellingShingle | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours Fateen Ata (12217764) Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis hypoglycaemia IGF 2 IGF II insulin-like growth factor-2 NICTH non-insulin mediated hypoglycaemia non-islet cell tumour hypoglycaemia |
| status_str | publishedVersion |
| title | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours |
| title_full | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours |
| title_fullStr | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours |
| title_full_unstemmed | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours |
| title_short | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours |
| title_sort | A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis hypoglycaemia IGF 2 IGF II insulin-like growth factor-2 NICTH non-insulin mediated hypoglycaemia non-islet cell tumour hypoglycaemia |