Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

<div><p>Background. Chemical biology approaches using small molecule inhibitors targeting specific signaling pathways are useful tools to dissect the molecular mechanisms governing stem cell differentiation and for their possible use in therapeutic interventions. Methods. Stem cell signa...

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Bibliographic Details
Main Author: Nihal AlMuraikhi (6002234) (author)
Other Authors: Dalia Ali (6002237) (author), Radhakrishnan Vishnubalaji (3563306) (author), Muthurangan Manikandan (6002243) (author), Muhammad Atteya (6002246) (author), Abdulaziz Siyal (6002249) (author), Musaad Alfayez (3571736) (author), Abdullah Aldahmash (3563300) (author), Moustapha Kassem (101848) (author), Nehad M. Alajez (7397276) (author)
Published: 2019
Subjects:
Biological sciences
Biochemistry and cell biology
Chemical Biology
Small Molecule Inhibitors
Signaling Pathways
Stem Cell Differentiation
Therapeutic Interventions
Human Bone Marrow Skeletal Stem Cells (hBMSCs)
Alkaline Phosphatase Activity
Osteoblastic Differentiation
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