COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males
<h2>Purpose</h2> <p>COVID-19 frequently affects the kidneys with symptoms ranging from mild proteinuria to progressive acute kidney injury. This prospective study aimed to assess the short- and long-term impact of asymptomatic and mild COVID-19 on the renal function of healthy youn...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513568145145856 |
|---|---|
| author | Khalid Al Rumaihi (14148804) |
| author2 | Kareim Khalafalla (14148807) Mohamed Arafa (14058042) Arun Nair (401341) Ahmad Al Bishawi (14148810) Areen Fino (14148813) Faheem Sirtaj (14148816) Mohamed Khair Ella (14148819) Haitham ElBardisi (14148822) Muhammad Abu Khattab (14148825) Ahmad Majzoub (14058045) |
| author2_role | author author author author author author author author author author |
| author_facet | Khalid Al Rumaihi (14148804) Kareim Khalafalla (14148807) Mohamed Arafa (14058042) Arun Nair (401341) Ahmad Al Bishawi (14148810) Areen Fino (14148813) Faheem Sirtaj (14148816) Mohamed Khair Ella (14148819) Haitham ElBardisi (14148822) Muhammad Abu Khattab (14148825) Ahmad Majzoub (14058045) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khalid Al Rumaihi (14148804) Kareim Khalafalla (14148807) Mohamed Arafa (14058042) Arun Nair (401341) Ahmad Al Bishawi (14148810) Areen Fino (14148813) Faheem Sirtaj (14148816) Mohamed Khair Ella (14148819) Haitham ElBardisi (14148822) Muhammad Abu Khattab (14148825) Ahmad Majzoub (14058045) |
| dc.date.none.fl_str_mv | 2022-11-22T21:11:19Z |
| dc.identifier.none.fl_str_mv | 10.1007/s11255-022-03301-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/COVID-19_and_renal_involvement_a_prospective_cohort_study_assessing_the_impact_of_mild_SARS-CoV-2_infection_on_the_kidney_function_of_young_healthy_males/21593862 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical sciences Urology Nephrology |
| dc.title.none.fl_str_mv | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Purpose</h2> <p>COVID-19 frequently affects the kidneys with symptoms ranging from mild proteinuria to progressive acute kidney injury. This prospective study aimed to assess the short- and long-term impact of asymptomatic and mild COVID-19 on the renal function of healthy young adults, and to determine the correlation between viral load and kidney function among these patients.</p> <h2>Methods</h2> <p>This was a prospective cohort study conducted over a period of 6 months. Patients were followed-up at baseline, and then after 3 and 6 months, respectively. Real-time PCR cycle threshold (CT) was used to determine the viral load and disease activity. Patients were classified into two groups with either asymptomatic COVID-19 or mild pneumonia. The assessment parameters were variables that could directly or indirectly relate to the renal function.</p> <h2>Results</h2> <p>A total of 48 patients were included and evaluated. The majority of patients (62.5%) had asymptomatic COVID-19 disease. Patients with mild pneumonia had significantly higher serum creatinine (SCr) at the time of COVID-19 diagnosis (beta = 12.836, 95% CI = 2.405–23.268, P = 0.019), after 3 months (beta = 14.345, 95% CI = 1.149–27.542, P = 0.035), and after 6 months (beta = 14.100, 95% CI = 0.730–27.470, P = 0.040) compared to asymptomatic patients. Mild pneumonia was also significantly associated with lower serum albumin level at the time of COVID-19 diagnosis (beta = – 6.317, 95% CI = – 9.448–− 3.185, P < 0.001).</p> <h2>Conclusion</h2> <p>Mild COVID-19 is associated with mild renal involvement without AKI. Changes in the renal function appear to be related to reduced creatinine clearance and possible albumin leakage in the acute phase of the disease. The reduction in creatinine clearance is not predicted by viral load, and it appears to be a long-term effect of the disease that can last for at least 6 months.</p><h2>Other Information</h2> <p> Published in: International Urology and Nephrology<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s11255-022-03301-6" target="_blank">http://dx.doi.org/10.1007/s11255-022-03301-6</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_891488b046e1053b53128e50208d82f3 |
| identifier_str_mv | 10.1007/s11255-022-03301-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21593862 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy malesKhalid Al Rumaihi (14148804)Kareim Khalafalla (14148807)Mohamed Arafa (14058042)Arun Nair (401341)Ahmad Al Bishawi (14148810)Areen Fino (14148813)Faheem Sirtaj (14148816)Mohamed Khair Ella (14148819)Haitham ElBardisi (14148822)Muhammad Abu Khattab (14148825)Ahmad Majzoub (14058045)Clinical sciencesUrologyNephrology<h2>Purpose</h2> <p>COVID-19 frequently affects the kidneys with symptoms ranging from mild proteinuria to progressive acute kidney injury. This prospective study aimed to assess the short- and long-term impact of asymptomatic and mild COVID-19 on the renal function of healthy young adults, and to determine the correlation between viral load and kidney function among these patients.</p> <h2>Methods</h2> <p>This was a prospective cohort study conducted over a period of 6 months. Patients were followed-up at baseline, and then after 3 and 6 months, respectively. Real-time PCR cycle threshold (CT) was used to determine the viral load and disease activity. Patients were classified into two groups with either asymptomatic COVID-19 or mild pneumonia. The assessment parameters were variables that could directly or indirectly relate to the renal function.</p> <h2>Results</h2> <p>A total of 48 patients were included and evaluated. The majority of patients (62.5%) had asymptomatic COVID-19 disease. Patients with mild pneumonia had significantly higher serum creatinine (SCr) at the time of COVID-19 diagnosis (beta = 12.836, 95% CI = 2.405–23.268, P = 0.019), after 3 months (beta = 14.345, 95% CI = 1.149–27.542, P = 0.035), and after 6 months (beta = 14.100, 95% CI = 0.730–27.470, P = 0.040) compared to asymptomatic patients. Mild pneumonia was also significantly associated with lower serum albumin level at the time of COVID-19 diagnosis (beta = – 6.317, 95% CI = – 9.448–− 3.185, P < 0.001).</p> <h2>Conclusion</h2> <p>Mild COVID-19 is associated with mild renal involvement without AKI. Changes in the renal function appear to be related to reduced creatinine clearance and possible albumin leakage in the acute phase of the disease. The reduction in creatinine clearance is not predicted by viral load, and it appears to be a long-term effect of the disease that can last for at least 6 months.</p><h2>Other Information</h2> <p> Published in: International Urology and Nephrology<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s11255-022-03301-6" target="_blank">http://dx.doi.org/10.1007/s11255-022-03301-6</a></p>2022-11-22T21:11:19ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s11255-022-03301-6https://figshare.com/articles/journal_contribution/COVID-19_and_renal_involvement_a_prospective_cohort_study_assessing_the_impact_of_mild_SARS-CoV-2_infection_on_the_kidney_function_of_young_healthy_males/21593862CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215938622022-11-22T21:11:19Z |
| spellingShingle | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males Khalid Al Rumaihi (14148804) Clinical sciences Urology Nephrology |
| status_str | publishedVersion |
| title | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males |
| title_full | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males |
| title_fullStr | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males |
| title_full_unstemmed | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males |
| title_short | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males |
| title_sort | COVID-19 and renal involvement: a prospective cohort study assessing the impact of mild SARS-CoV-2 infection on the kidney function of young healthy males |
| topic | Clinical sciences Urology Nephrology |